Aficamten

Drug profile

Key facts

Aficamten is an onp drug catalogued in DrugCentral. It was first approved by the FDA in 2025. DrugCentral lists 1 molecular target, including MYH7. Recorded indications include Obstructive hypertrophic cardiomyopathy (HCM).

• Approval status: onp (first approved 2025 by the FDA).
• Molecular targets: MYH7 (1 listed in DrugCentral).
• Indications: Obstructive hypertrophic cardiomyopathy (HCM).
• Molecular formula: C18H19N5O2; molecular weight 337.38 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Obstructive hypertrophic cardiomyopathy (HCM)

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Myosin-7	MYH7	inhibitor	IC50 6.00

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2026-02-12	EMA	—	Cytokinetics (Ireland) Limited	Yes
2025-12-19	FDA	—	Cytokinetics	Yes

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Aficamten is on its molecule page.

• Molecular formula: C₁₈H₁₉N₅O₂
• Molecular weight: 337.38 g/mol
• CAS number: —
• InChIKey: IOVAZWDIRCRMTM-OAHLLOKOSA-N
• PubChem CID: 139331495

CCC1=NC(=NO1)C2=CC3=C(C=C2)[C@@H](CC3)NC(=O)C4=CN(N=C4)C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Aficamten used for?

DrugCentral lists the following indications for Aficamten: Obstructive hypertrophic cardiomyopathy (HCM).

How does Aficamten work?

Its molecular targets in DrugCentral include MYH7 (inhibitor).

When was Aficamten first approved?

Aficamten was first approved by the FDA in 2025.

What is the chemical formula of Aficamten?

Aficamten has the molecular formula C18H19N5O2 and a molecular weight of 337.38 g/mol.

Sources

• DrugCentral drug card 5800 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL4847050 — compound record and bioactivity
• PubChem CID 139331495 — chemical identifiers
• FDA UNII B1I77MH6K1 — substance identity
• DailyMed: FDA labels for Aficamten — current prescribing information (label search)
• UniProt P12883 (MYH7) — target protein

How this page is built: methodology · editorial policy & corrections.