Beclabuvir

ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Beclabuvir is a drug catalogued in DrugCentral. It was first approved by the PMDA in 2016. DrugCentral lists 3 molecular targets, including NS5B, NS5b and KCNH2. Recorded indications include Chronic hepatitis C.

• Molecular targets: NS5B, NS5b and KCNH2 (3 listed in DrugCentral).
• Indications: Chronic hepatitis C.
• ATC code: J05AP58 (Antivirals for treatment of HCV infections).
• Molecular formula: C36H45N5O5S; molecular weight 659.85 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Chronic hepatitis C

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
NS5B protein	NS5B	unknown	IC50 6.72
RNA-directed RNA polymerase	NS5b	unknown	IC50 6.72
Potassium voltage-gated channel subfamily H member 2	KCNH2	unknown	IC50 4.61

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2016-12-19	PMDA	—	Bristol-Myers Squibb

ATC classification

ATC code	Therapeutic hierarchy
J05AP58	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIVIRALS FOR SYSTEMIC USE › DIRECT ACTING ANTIVIRALS › Antivirals for treatment of HCV infections

Chemical structure

• Molecular formula: C₃₆H₄₅N₅O₅S
• Molecular weight: 659.85 g/mol
• CAS number: 958002-33-0
• InChIKey: ZTTKEBYSXUCBSE-VSBZUFFNSA-N
• PubChem CID: 56934415

COC1=CC=C2C3=C(C4CCCCC4)C4=CC=C(C=C4N3C[C@]3(C[C@H]3C2=C1)C(=O)N1C2CCC1CN(C)C2)C(=O)NS(=O)(=O)N(C)C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Beclabuvir used for?

DrugCentral lists the following indications for Beclabuvir: Chronic hepatitis C.

How does Beclabuvir work?

Its molecular targets in DrugCentral include NS5B, NS5b and KCNH2.

When was Beclabuvir first approved?

Beclabuvir was first approved by the PMDA in 2016.

What is the chemical formula of Beclabuvir?

Beclabuvir has the molecular formula C36H45N5O5S and a molecular weight of 659.85 g/mol.

Sources

• DrugCentral drug card 5215 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL4105584 — compound record and bioactivity
• PubChem CID 56934415 — chemical identifiers
• DrugBank DB12225 — drug record
• FDA UNII MYW1X5CO9S — substance identity
• UniProt Q12809 (KCNH2) — target protein

How this page is built: methodology · editorial policy & corrections.