Belotecan

ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

Key facts

Belotecan is a drug catalogued in DrugCentral. It was first approved by the Korean Food and Drug Administration (KFDA) in 2003. DrugCentral lists 1 molecular target, including TOP1. Recorded indications include Malignant tumor of ovary and Non-small cell lung cancer.

• Molecular targets: TOP1 (1 listed in DrugCentral).
• Indications: Malignant tumor of ovary and Non-small cell lung cancer.
• ATC code: L01CE04 (Topoisomerase 1 (TOP1) inhibitors).
• Molecular formula: C25H27N3O4; molecular weight 433.51 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Malignant tumor of ovary
• Non-small cell lung cancer

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
DNA topoisomerase 1	TOP1	inhibitor	IC50 6.56

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2003-12-10	Korean Food and Drug Administration (KFDA)	—	Chong Kun Dang

ATC classification

ATC code	Therapeutic hierarchy
L01CE04	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › ANTINEOPLASTIC AGENTS › PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS › Topoisomerase 1 (TOP1) inhibitors

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Belotecan is on its molecule page.

• Molecular formula: C₂₅H₂₇N₃O₄
• Molecular weight: 433.51 g/mol
• CAS number: 256411-32-2
• InChIKey: LNHWXBUNXOXMRL-VWLOTQADSA-N
• PubChem CID: 6456014

CC[C@@]1(O)C(=O)OCC2=C1C=C1N(CC3=C(CCNC(C)C)C4=CC=CC=C4N=C13)C2=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Belotecan used for?

DrugCentral lists the following indications for Belotecan: Malignant tumor of ovary and Non-small cell lung cancer.

How does Belotecan work?

Its molecular targets in DrugCentral include TOP1 (inhibitor).

When was Belotecan first approved?

Belotecan was first approved by the Korean Food and Drug Administration (KFDA) in 2003.

What is the chemical formula of Belotecan?

Belotecan has the molecular formula C25H27N3O4 and a molecular weight of 433.51 g/mol.

Sources

• DrugCentral drug card 296 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2107315 — compound record and bioactivity
• PubChem CID 6456014 — chemical identifiers
• DrugBank DB12459 — drug record
• FDA UNII 27Z82M2G1N — substance identity
• UniProt P11387 (TOP1) — target protein

How this page is built: methodology · editorial policy & corrections.