Elexacaftor

RESPIRATORY SYSTEM

Key facts

Elexacaftor is an onp drug catalogued in DrugCentral. It was first approved by the FDA in 2019. DrugCentral lists 1 molecular target, including CFTR. Recorded indications include Cystic fibrosis.

• Approval status: onp (first approved 2019 by the FDA).
• Molecular targets: CFTR (1 listed in DrugCentral).
• Indications: Cystic fibrosis.
• ATC code: R07AX32 (Other respiratory system products).
• Molecular formula: C26H34F3N7O4S; molecular weight 597.66 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Cystic fibrosis

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Cystic fibrosis transmembrane conductance regulator	CFTR	unknown	EC50 7.15

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2020-08-21	EMA	—	Vertex Pharmaceuticals (Ireland) Limited	Yes
2019-10-10	FDA	—	VERTEX PHARMS INC

ATC classification

ATC code	Therapeutic hierarchy
R07AX32	RESPIRATORY SYSTEM › OTHER RESPIRATORY SYSTEM PRODUCTS › OTHER RESPIRATORY SYSTEM PRODUCTS › Other respiratory system products

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Elexacaftor is on its molecule page.

• Molecular formula: C₂₆H₃₄F₃N₇O₄S
• Molecular weight: 597.66 g/mol
• CAS number: 2216712-66-0
• InChIKey: MVRHVFSOIWFBTE-INIZCTEOSA-N
• PubChem CID: 134587348

C[C@@H]1CN(C2=C(C=CC(=N2)N2C=CC(OCC(C)(C)C(F)(F)F)=N2)C(=O)NS(=O)(=O)C2=CN(C)N=C2C)C(C)(C)C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Elexacaftor used for?

DrugCentral lists the following indications for Elexacaftor: Cystic fibrosis.

How does Elexacaftor work?

Its molecular targets in DrugCentral include CFTR.

When was Elexacaftor first approved?

Elexacaftor was first approved by the FDA in 2019.

What is the chemical formula of Elexacaftor?

Elexacaftor has the molecular formula C26H34F3N7O4S and a molecular weight of 597.66 g/mol.

Sources

• DrugCentral drug card 5372 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL4298128 — compound record and bioactivity
• PubChem CID 134587348 — chemical identifiers
• DrugBank DB15444 — drug record
• FDA UNII RRN67GMB0V — substance identity
• DailyMed: FDA labels for Elexacaftor — current prescribing information (label search)
• UniProt P13569 (CFTR) — target protein

How this page is built: methodology · editorial policy & corrections.