Ensitrelvir

ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Ensitrelvir is an onp drug catalogued in DrugCentral. It was first approved by the PMDA in 2022. DrugCentral lists 1 molecular target, including REP. Recorded indications include Disease caused by Severe acute respiratory syndrome coronavirus 2.

• Approval status: onp (first approved 2022 by the PMDA).
• Molecular targets: REP (1 listed in DrugCentral).
• Indications: Disease caused by Severe acute respiratory syndrome coronavirus 2.
• ATC code: J05AE16 (Protease inhibitors).
• Molecular formula: C22H17ClF3N9O2; molecular weight 531.88 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Disease caused by Severe acute respiratory syndrome coronavirus 2

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Replicase polyprotein 1ab	REP	inhibitor	IC50 7.31

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2022-11-22	PMDA	—	Shionogi & Co., Ltd.

ATC classification

ATC code	Therapeutic hierarchy
J05AE16	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIVIRALS FOR SYSTEMIC USE › DIRECT ACTING ANTIVIRALS › Protease inhibitors

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Ensitrelvir is on its molecule page.

• Molecular formula: C₂₂H₁₇ClF₃N₉O₂
• Molecular weight: 531.88 g/mol
• CAS number: 2647530-73-0
• InChIKey: QMPBBNUOBOFBFS-UHFFFAOYSA-N
• PubChem CID: 162533924

CN1C=NC(CN2C(=O)N\C(=N/C3=CC4=CN(C)N=C4C=C3Cl)N(CC3=CC(F)=C(F)C=C3F)C2=O)=N1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Ensitrelvir used for?

DrugCentral lists the following indications for Ensitrelvir: Disease caused by Severe acute respiratory syndrome coronavirus 2.

How does Ensitrelvir work?

Its molecular targets in DrugCentral include REP (inhibitor).

When was Ensitrelvir first approved?

Ensitrelvir was first approved by the PMDA in 2022.

What is the chemical formula of Ensitrelvir?

Ensitrelvir has the molecular formula C22H17ClF3N9O2 and a molecular weight of 531.88 g/mol.

Sources

• DrugCentral drug card 5727 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL5183847 — compound record and bioactivity
• PubChem CID 162533924 — chemical identifiers
• FDA UNII PX665RAA3H — substance identity

How this page is built: methodology · editorial policy & corrections.