Etripamil

CARDIOVASCULAR SYSTEM

Key facts

Etripamil is an onp drug catalogued in DrugCentral. It was first approved by the FDA in 2025. DrugCentral lists 1 molecular target, including CACNA1C. Recorded indications include Paroxysmal supraventricular tachycardia.

• Approval status: onp (first approved 2025 by the FDA).
• Molecular targets: CACNA1C (1 listed in DrugCentral).
• Indications: Paroxysmal supraventricular tachycardia.
• ATC code: C08DA03 (Phenylalkylamine derivatives).
• Molecular formula: C27H36N2O4; molecular weight 452.60 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Paroxysmal supraventricular tachycardia

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	blocker	IC50 7.64

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2025-12-12	FDA	—	Milestone Pharmaceuticals

ATC classification

ATC code	Therapeutic hierarchy
C08DA03	CARDIOVASCULAR SYSTEM › CALCIUM CHANNEL BLOCKERS › SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS › Phenylalkylamine derivatives

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Etripamil is on its molecule page.

• Molecular formula: C₂₇H₃₆N₂O₄
• Molecular weight: 452.60 g/mol
• CAS number: —
• InChIKey: VAZNEHLGJGSQEL-MHZLTWQESA-N
• PubChem CID: 91824132

CC(C)[C@](CCCN(C)CCC1=CC(=CC=C1)C(=O)OC)(C#N)C2=CC(=C(C=C2)OC)OC

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Etripamil used for?

DrugCentral lists the following indications for Etripamil: Paroxysmal supraventricular tachycardia.

How does Etripamil work?

Its molecular targets in DrugCentral include CACNA1C (blocker).

When was Etripamil first approved?

Etripamil was first approved by the FDA in 2025.

What is the chemical formula of Etripamil?

Etripamil has the molecular formula C27H36N2O4 and a molecular weight of 452.60 g/mol.

Sources

• DrugCentral drug card 5792 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL3707312 — compound record and bioactivity
• PubChem CID 91824132 — chemical identifiers
• DrugBank DB12605 — drug record
• FDA UNII S82A18Y42P — substance identity
• DailyMed: FDA labels for Etripamil — current prescribing information (label search)
• UniProt Q13936 (CACNA1C) — target protein

How this page is built: methodology · editorial policy & corrections.