Galantamine

Cholinesterase Inhibitor — NERVOUS SYSTEM

Key facts

Galantamine is an ofp drug in the Cholinesterase Inhibitor class catalogued in DrugCentral. It was first approved by the FDA in 2001. Its mechanism of action is classified as Cholinesterase Inhibitors. DrugCentral lists 10 molecular targets, including ACHE, BCHE and ache. Recorded indications include Alzheimer's disease.

• Approval status: ofp (first approved 2001 by the FDA).
• Drug class: Cholinesterase Inhibitor.
• Mechanism of action: Cholinesterase Inhibitors.
• Molecular targets: ACHE, BCHE, ache and ache (10 listed in DrugCentral).
• Indications: Alzheimer's disease.
• ATC code: N06DA04 (Anticholinesterases).
• Molecular formula: C17H21NO3; molecular weight 287.36 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Alzheimer's disease

Off-label uses (2)

• Diffuse Lewy body disease
• Moderate to Severe Alzheimer's Type Dementia

Contraindications (14)

• Acute nephropathy
• Asthma
• Atrioventricular block
• Bladder outflow obstruction
• Bradycardia
• Chronic obstructive lung disease
• Congenital long QT syndrome
• Disease of liver
• Duodenal ulcer disease
• Epilepsy
• Gastrointestinal ulcer
• Hepatic failure
• Kidney disease
• Peptic ulcer

Mechanism & targets

• Mechanism of action (MoA): Cholinesterase Inhibitors
• Established pharmacologic class: Cholinesterase Inhibitor

Molecular targets (10)

Target	Gene	Action	Activity
Acetylcholinesterase	ACHE	inhibitor	Ki 7.21
Cholinesterase	BCHE	unknown	Ki 6.72
Acetylcholinesterase	ache	unknown	IC50 6.44
Acetylcholinesterase	ache	unknown	Ki 6.37
Acetylcholinesterase	Ache	unknown	IC50 6.27
Acetylcholinesterase	Ache	unknown	IC50 5.60
Butyrylcholinesterase; Protein Bche	Bche	unknown	IC50 5.23
Butyrylcholinesterase	BCHE	unknown	Ki 5.10
Acetylcholinesterase	ACHE	unknown	IC50 5.06
Cholinesterase	BCHE	unknown	Ki 5.03

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2001-02-28	FDA	—	JANSSEN PHARMS

ATC classification

ATC code	Therapeutic hierarchy
N06DA04	NERVOUS SYSTEM › PSYCHOANALEPTICS › ANTI-DEMENTIA DRUGS › Anticholinesterases

Pharmacogenomics

Drug-label and guideline annotations from PharmGKB and CPIC.

• FDA label: CYP2D6 · No Clinical PGx
• HCSC label: CYP2D6 · No Clinical PGx
• Swissmedic label: CYP2D6 · Informative PGx

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Creatinine renal clearance decreased	1836.5
Sedation complication	1825.7
Orthostatic hypotension	1656.3
Blood calcium decreased	1572.0
Cognitive disorder	1535.6
Sedation	1532.6
Balance disorder	1321.8
Depressed level of consciousness	1246.3
Fall	934.9
Constipation	800.4
Mobility decreased	720.3
Hypotension	692.1

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Galantamine is on its molecule page.

• Molecular formula: C₁₇H₂₁NO₃
• Molecular weight: 287.36 g/mol
• CAS number: 357-70-0
• InChIKey: ASUTZQLVASHGKV-JDFRZJQESA-N
• PubChem CID: 9651

COC1=CC=C2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3OC1=C24

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Galantamine used for?

DrugCentral lists the following indications for Galantamine: Alzheimer's disease.

How does Galantamine work?

Galantamine is classified as Cholinesterase Inhibitors; its molecular targets in DrugCentral include ACHE (inhibitor), BCHE, ache and ache.

When was Galantamine first approved?

Galantamine was first approved by the FDA in 2001.

What drug class does Galantamine belong to?

Galantamine is in the Cholinesterase Inhibitor class.

What is the chemical formula of Galantamine?

Galantamine has the molecular formula C17H21NO3 and a molecular weight of 287.36 g/mol.

Sources

• DrugCentral drug card 1272 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1555 — compound record and bioactivity
• PubChem CID 9651 — chemical identifiers
• DrugBank DB00674 — drug record
• FDA UNII 0D3Q044KCA — substance identity
• DailyMed: FDA labels for Galantamine — current prescribing information (label search)
• UniProt P22303 (ACHE) — target protein
• UniProt P06276 (BCHE) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
• PharmGKB / CPIC — pharmacogenomic label annotations

How this page is built: methodology · editorial policy & corrections.