Guanidine
Acetylcholine Releasing Agent
Also known as: aminoformamidine, carbamamidine, guanidin, guanidine HCl, guanidine hydrochloride, iminourea
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Guanidine is a drug in the Acetylcholine Releasing Agent class catalogued in DrugCentral. It was first approved by the FDA in 1939. DrugCentral lists 1 molecular target, including KCNQ3|KCNQ2|KCNH1|KCNA2|KCNA6|KCNA3|KCNA4|KCNA5|KCNC1|KCNQ1|KCNQ4|KCNC4|KCNA1|KCNH2|KCNC3|KCNB1|KCNA10|KCNV1|KCNH5|KCNG3|KCNG4|KCNV2|KCNB2|KCNS1|KCNH8|KCNC2|KCNA7|KCNS3|KCNH6|KCNF1|KCNQ5|KCNH7|KCND1|KCND2|KCNG1|KCNG2|KCND3|KCNH3|KCNS2|KCNH4. Recorded indications include Eaton-Lambert syndrome.
- Drug class: Acetylcholine Releasing Agent.
- Molecular targets: KCNQ3|KCNQ2|KCNH1|KCNA2|KCNA6|KCNA3|KCNA4|KCNA5|KCNC1|KCNQ1|KCNQ4|KCNC4|KCNA1|KCNH2|KCNC3|KCNB1|KCNA10|KCNV1|KCNH5|KCNG3|KCNG4|KCNV2|KCNB2|KCNS1|KCNH8|KCNC2|KCNA7|KCNS3|KCNH6|KCNF1|KCNQ5|KCNH7|KCND1|KCND2|KCNG1|KCNG2|KCND3|KCNH3|KCNS2|KCNH4 (1 listed in DrugCentral).
- Indications: Eaton-Lambert syndrome.
- Molecular formula: CH5N3; molecular weight 59.07 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (1)
- Eaton-Lambert syndrome
Contraindications (5)
- Anemia
- Breastfeeding (mother)
- Leukopenia
- Pregnancy, function
- Thrombocytopenic disorder
Mechanism & targets
| Established pharmacologic class | Acetylcholine Releasing Agent |
|---|
Molecular targets (1)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Voltage-gated potassium channel | KCNQ3|KCNQ2|KCNH1|KCNA2|KCNA6|KCNA3|KCNA4|KCNA5|KCNC1|KCNQ1|KCNQ4|KCNC4|KCNA1|KCNH2|KCNC3|KCNB1|KCNA10|KCNV1|KCNH5|KCNG3|KCNG4|KCNV2|KCNB2|KCNS1|KCNH8|KCNC2|KCNA7|KCNS3|KCNH6|KCNF1|KCNQ5|KCNH7|KCND1|KCND2|KCNG1|KCNG2|KCND3|KCNH3|KCNS2|KCNH4 | blocker | — |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1939-10-02 | FDA | — | MERCK SHARP DOHME |
Reported adverse-event signals
Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.
| MedDRA term | LLR |
|---|---|
| Pulmonary pain | 446.4 |
| Amyloid arthropathy | 291.8 |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Guanidine is on its molecule page.
| Molecular formula | CH5N3 |
|---|---|
| Molecular weight | 59.07 g/mol |
| CAS number | — |
| InChIKey | ZRALSGWEFCBTJO-UHFFFAOYSA-N |
| PubChem CID | 3520 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Guanidine used for?
DrugCentral lists the following indications for Guanidine: Eaton-Lambert syndrome.
How does Guanidine work?
Its molecular targets in DrugCentral include KCNQ3|KCNQ2|KCNH1|KCNA2|KCNA6|KCNA3|KCNA4|KCNA5|KCNC1|KCNQ1|KCNQ4|KCNC4|KCNA1|KCNH2|KCNC3|KCNB1|KCNA10|KCNV1|KCNH5|KCNG3|KCNG4|KCNV2|KCNB2|KCNS1|KCNH8|KCNC2|KCNA7|KCNS3|KCNH6|KCNF1|KCNQ5|KCNH7|KCND1|KCND2|KCNG1|KCNG2|KCND3|KCNH3|KCNS2|KCNH4 (blocker).
When was Guanidine first approved?
Guanidine was first approved by the FDA in 1939.
What drug class does Guanidine belong to?
Guanidine is in the Acetylcholine Releasing Agent class.
What is the chemical formula of Guanidine?
Guanidine has the molecular formula CH5N3 and a molecular weight of 59.07 g/mol.
Browse: all drugs starting with G · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 1344 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL1200728 — compound record and bioactivity
- PubChem CID 3520 — chemical identifiers
- DrugBank DB00536 — drug record
- FDA UNII JU58VJ6Y3B — substance identity
- DailyMed: FDA labels for Guanidine — current prescribing information (label search)
- FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
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