Ibutilide

Antiarrhythmic — CARDIOVASCULAR SYSTEM

Key facts

Ibutilide is an ofp drug in the Antiarrhythmic class catalogued in DrugCentral. It was first approved by the FDA in 1995. DrugCentral lists 1 molecular target, including KCNH2. Recorded indications include Cardioversion of Atrial Fibrillation and Cardioversion of Atrial Flutter.

• Approval status: ofp (first approved 1995 by the FDA).
• Drug class: Antiarrhythmic.
• Molecular targets: KCNH2 (1 listed in DrugCentral).
• Indications: Cardioversion of Atrial Fibrillation and Cardioversion of Atrial Flutter.
• ATC code: C01BD05 (Antiarrhythmics, class III).
• Molecular formula: C20H36N2O3S; molecular weight 384.59 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Cardioversion of Atrial Fibrillation
• Cardioversion of Atrial Flutter

Contraindications (7)

• Bradycardia
• Congenital long QT syndrome
• Heart block
• Hypokalemia
• Hypomagnesemia
• Prolonged QT interval
• Torsades de pointes

Mechanism & targets

• Established pharmacologic class: Antiarrhythmic

Molecular targets (1)

Target	Gene	Action	Activity
Potassium voltage-gated channel subfamily H member 2	KCNH2	blocker	IC50 8.00

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1995-12-28	FDA	—	PHARMACIA AND UPJOHN

ATC classification

ATC code	Therapeutic hierarchy
C01BD05	CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › ANTIARRHYTHMICS, CLASS I AND III › Antiarrhythmics, class III

Chemical structure

• Molecular formula: C₂₀H₃₆N₂O₃S
• Molecular weight: 384.59 g/mol
• CAS number: —
• InChIKey: ALOBUEHUHMBRLE-UHFFFAOYSA-N
• PubChem CID: 60753

CCCCCCCN(CC)CCCC(O)C1=CC=C(NS(C)(=O)=O)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Ibutilide used for?

DrugCentral lists the following indications for Ibutilide: Cardioversion of Atrial Fibrillation and Cardioversion of Atrial Flutter.

How does Ibutilide work?

Its molecular targets in DrugCentral include KCNH2 (blocker).

When was Ibutilide first approved?

Ibutilide was first approved by the FDA in 1995.

What drug class does Ibutilide belong to?

Ibutilide is in the Antiarrhythmic class.

What is the chemical formula of Ibutilide?

Ibutilide has the molecular formula C20H36N2O3S and a molecular weight of 384.59 g/mol.

Sources

• DrugCentral drug card 1412 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2355456 — compound record and bioactivity
• PubChem CID 60753 — chemical identifiers
• DrugBank DB00308 — drug record
• FDA UNII 2436VX1U9B — substance identity
• DailyMed: FDA labels for Ibutilide — current prescribing information (label search)
• UniProt Q12809 (KCNH2) — target protein

How this page is built: methodology · editorial policy & corrections.