Isosorbide dinitrate

Nitrate Vasodilator — CARDIOVASCULAR SYSTEM

Key facts

Isosorbide dinitrate is an ofp drug in the Nitrate Vasodilator class catalogued in DrugCentral. It was first approved by the FDA in 1968. DrugCentral lists 2 molecular targets, including NPR1 and GUCY1B2|GUCY1A2|GUCY1A3|GUCY1B3. Recorded indications include Angina pectoris, Angina Pectoris Prevention and Chronic heart failure.

• Approval status: ofp (first approved 1968 by the FDA).
• Drug class: Nitrate Vasodilator.
• Molecular targets: NPR1 and GUCY1B2|GUCY1A2|GUCY1A3|GUCY1B3 (2 listed in DrugCentral).
• Indications: Angina pectoris, Angina Pectoris Prevention and Chronic heart failure.
• ATC code: C01DA08 (Organic nitrates).
• Molecular formula: C6H8N2O8; molecular weight 236.14 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• Angina pectoris
• Angina Pectoris Prevention
• Chronic heart failure

Off-label uses (1)

• Prevention of Bleeding Esophageal Varices

Contraindications (16)

• Anemia
• Benign intracranial hypertension
• Cerebral hemorrhage
• Cerebrovascular accident
• Disorder of coronary artery
• Hyperthyroidism
• Hypertrophic cardiomyopathy
• Hypovolemia
• Increased intestinal motility
• Injury of head
• Low blood pressure
• Lupus erythematosus and erythema multiforme-like syndrome
• Malabsorption States
• Myocardial infarction
• Myocardial infarction in recovery phase
• Slow acetylator due to N-acetyltransferase enzyme variant

Mechanism & targets

• Established pharmacologic class: Nitrate Vasodilator

Molecular targets (2)

Target	Gene	Action	Activity
Atrial natriuretic peptide receptor 1	NPR1	unknown	—
Soluble guanylate cyclase	GUCY1B2|GUCY1A2|GUCY1A3|GUCY1B3	activator	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1968-01-16	FDA	—	ASTRAZENECA

ATC classification

ATC code	Therapeutic hierarchy
C01DA08	CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › VASODILATORS USED IN CARDIAC DISEASES › Organic nitrates
C01DA58	CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › VASODILATORS USED IN CARDIAC DISEASES › Organic nitrates
C05AE02	CARDIOVASCULAR SYSTEM › VASOPROTECTIVES › AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE › Muscle relaxants

Pharmacogenomics

Drug-label and guideline annotations from PharmGKB and CPIC.

• FDA label: CYB5R1, CYB5R2, CYB5R3, CYB5R4 · Informative PGx

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Cardiospasm	668.1
Myocardial infarction	651.5
Palmoplantar keratoderma	640.9
Pruritus genital	603.7
Sleep terror	597.2
Carotid artery occlusion	567.4
Atrial tachycardia	566.4
Tension headache	538.3
Subarachnoid haemorrhage	473.1
Anosmia	471.5
Facial pain	453.7
Immunisation	438.5

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Isosorbide dinitrate is on its molecule page.

• Molecular formula: C₆H₈N₂O₈
• Molecular weight: 236.14 g/mol
• CAS number: 87-33-2
• InChIKey: MOYKHGMNXAOIAT-JGWLITMVSA-N
• PubChem CID: 6883

[O-][N+](=O)O[C@@H]1CO[C@@H]2[C@H](CO[C@H]12)O[N+]([O-])=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Isosorbide dinitrate used for?

DrugCentral lists the following indications for Isosorbide dinitrate: Angina pectoris, Angina Pectoris Prevention and Chronic heart failure.

How does Isosorbide dinitrate work?

Its molecular targets in DrugCentral include NPR1 and GUCY1B2|GUCY1A2|GUCY1A3|GUCY1B3 (activator).

When was Isosorbide dinitrate first approved?

Isosorbide dinitrate was first approved by the FDA in 1968.

What drug class does Isosorbide dinitrate belong to?

Isosorbide dinitrate is in the Nitrate Vasodilator class.

What is the chemical formula of Isosorbide dinitrate?

Isosorbide dinitrate has the molecular formula C6H8N2O8 and a molecular weight of 236.14 g/mol.

Sources

• DrugCentral drug card 1505 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL6622 — compound record and bioactivity
• PubChem CID 6883 — chemical identifiers
• DrugBank DB00883 — drug record
• FDA UNII IA7306519N — substance identity
• DailyMed: FDA labels for Isosorbide dinitrate — current prescribing information (label search)
• UniProt P16066 (NPR1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
• PharmGKB / CPIC — pharmacogenomic label annotations

How this page is built: methodology · editorial policy & corrections.