Meprobamate

NERVOUS SYSTEM

Key facts

Meprobamate is an ofp drug catalogued in DrugCentral. It was first approved by the FDA in 1955. DrugCentral lists 5 molecular targets, including ABCB1, GABRG2|GABRB3|GABRA2 and GABRG2|GABRB3|GABRA3. Recorded indications include Anxiety, Anxiety associated with Menopause and Pain with Tension and Anxiety.

• Approval status: ofp (first approved 1955 by the FDA).
• Molecular targets: ABCB1, GABRG2|GABRB3|GABRA2, GABRG2|GABRB3|GABRA3 and GABRG2|GABRB3|GABRA5 (5 listed in DrugCentral).
• Indications: Anxiety, Anxiety associated with Menopause and Pain with Tension and Anxiety.
• ATC code: N05BC01 (Carbamates).
• Molecular formula: C9H18N2O4; molecular weight 218.25 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• Anxiety
• Anxiety associated with Menopause
• Pain with Tension and Anxiety

Contraindications (68)

• Acute erosive gastritis
• Acute intermittent porphyria
• Acute nephropathy
• Alcoholism
• Anemia
• Anemia due to enzyme deficiency
• Asthma
• Body fluid retention
• Breast lump
• Breastfeeding (mother)
• Carcinoma of female breast
• Cardiovascular event risk
• Cerebrovascular accident
• Chloasma
• Chorea
• Deep venous thrombosis
• Dementia
• Diabetes mellitus
• Disease of liver
• Disorder of coronary artery
• Disorder of gallbladder
• Endometrial carcinoma
• Endometriosis
• Epilepsy
• Estrogen receptor positive tumor
• Factor II deficiency
• Family history of malignant neoplasm of breast
• Functional visual loss
• Gastrointestinal hemorrhage
• Gastrointestinal ulcer
• + 38 more

Mechanism & targets

Molecular targets (5)

Target	Gene	Action	Activity
Multidrug resistance protein 1	ABCB1	unknown	IC50 6.82
GABA-A receptor alpha-2/beta-3/gamma-2	GABRG2|GABRB3|GABRA2	agonist	—
GABA-A receptor alpha-3/beta-3/gamma-2	GABRG2|GABRB3|GABRA3	agonist	—
GABA-A receptor alpha-5/beta-3/gamma-2	GABRG2|GABRB3|GABRA5	agonist	—
GABA-A receptor alpha-1/beta-3/gamma-2	GABRA1|GABRG2|GABRB3	agonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1955-04-28	FDA	—	MEDPOINTE PHARM HLC

ATC classification

ATC code	Therapeutic hierarchy
N05BC01	NERVOUS SYSTEM › PSYCHOLEPTICS › ANXIOLYTICS › Carbamates
N05BC51	NERVOUS SYSTEM › PSYCHOLEPTICS › ANXIOLYTICS › Carbamates
N05CX01	NERVOUS SYSTEM › PSYCHOLEPTICS › HYPNOTICS AND SEDATIVES › Hypnotics and sedatives in combination, excl. barbiturates

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Toxicity to various agents	834.8
Drug abuse	378.3
Accidental overdose	350.8
Overdose	255.7
Respiratory arrest	213.2
Completed suicide	192.0
Accidental death	178.4
Cardiac arrest	169.0
Pulmonary oedema	90.2
Cardio-respiratory arrest	75.6
Pulmonary congestion	74.7
Drug screen positive	71.2

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Meprobamate is on its molecule page.

• Molecular formula: C₉H₁₈N₂O₄
• Molecular weight: 218.25 g/mol
• CAS number: 57-53-4
• InChIKey: NPPQSCRMBWNHMW-UHFFFAOYSA-N
• PubChem CID: 4064

CCCC(C)(COC(N)=O)COC(N)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Meprobamate used for?

DrugCentral lists the following indications for Meprobamate: Anxiety, Anxiety associated with Menopause and Pain with Tension and Anxiety.

How does Meprobamate work?

Its molecular targets in DrugCentral include ABCB1, GABRG2|GABRB3|GABRA2 (agonist), GABRG2|GABRB3|GABRA3 (agonist) and GABRG2|GABRB3|GABRA5 (agonist).

When was Meprobamate first approved?

Meprobamate was first approved by the FDA in 1955.

What is the chemical formula of Meprobamate?

Meprobamate has the molecular formula C9H18N2O4 and a molecular weight of 218.25 g/mol.

Sources

• DrugCentral drug card 1704 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL979 — compound record and bioactivity
• PubChem CID 4064 — chemical identifiers
• DrugBank DB00371 — drug record
• FDA UNII 9I7LNY769Q — substance identity
• DailyMed: FDA labels for Meprobamate — current prescribing information (label search)
• UniProt P08183 (ABCB1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.