Motugivatrep

Drug profile

Also known as: avarept, SJP-0132

PMDA approved

Data last refreshed: 2026-11-10 (DrugCentral release 2024-11-01)

Open interactive profile (3D, safety, PGx)

Key facts

Motugivatrep is a drug catalogued in DrugCentral. It was first approved by the PMDA in 2025. DrugCentral lists 1 molecular target, including TRPV1. Recorded indications include Dry eye disease.

Molecular targets: TRPV1 (1 listed in DrugCentral).
Indications: Dry eye disease.
Molecular formula: C22H20F3NO3; molecular weight 403.40 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

Dry eye disease

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Transient receptor potential cation channel subfamily V member 1	TRPV1	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2025-12-22	PMDA	—	Senju Pharmaceutical Co., Ltd.

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Motugivatrep is on its molecule page.

Molecular formula	C₂₂H₂₀F₃NO₃
Molecular weight	403.40 g/mol
CAS number	920332-28-1
InChIKey	MAWBBYZCTDJMDD-HFQYIWAZSA-N
PubChem CID	137350798

C1CC2=C(C[C@@H]1O)C(=CC=C2)NC(=O)/C=C/3\CCOC4=C3C=CC(=C4)C(F)(F)F

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Motugivatrep used for?

DrugCentral lists the following indications for Motugivatrep: Dry eye disease.

How does Motugivatrep work?

Its molecular targets in DrugCentral include TRPV1 (inhibitor).

When was Motugivatrep first approved?

Motugivatrep was first approved by the PMDA in 2025.

What is the chemical formula of Motugivatrep?

Motugivatrep has the molecular formula C22H20F3NO3 and a molecular weight of 403.40 g/mol.

Browse: all drugs starting with M · drug guides by category · protein targets A–Z.

Sources

DrugCentral drug card 5795 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
ChEMBL CHEMBL5095073 — compound record and bioactivity
PubChem CID 137350798 — chemical identifiers
FDA UNII 7SHP2FH6HQ — substance identity
UniProt Q8NER1 (TRPV1) — target protein

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