Ouabain

CARDIOVASCULAR SYSTEM

Key facts

Ouabain is a drug catalogued in DrugCentral. It was first approved by the YEAR INTRODUCED in 1865. DrugCentral lists 4 molecular targets, including ATP1A2, STAT3 and KCNH2.

• Molecular targets: ATP1A2, STAT3, KCNH2 and ATP1A1 (4 listed in DrugCentral).
• ATC code: C01AC01 (Strophanthus glycosides).
• Molecular formula: C29H44O12; molecular weight 584.66 g/mol.

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
Sodium/potassium-transporting ATPase subunit alpha-2	ATP1A2	unknown	IC50 6.17
Signal transducer and activator of transcription 3	STAT3	unknown	IC50 5.94
Potassium voltage-gated channel subfamily H member 2	KCNH2	unknown	IC50 5.01
Sodium/potassium-transporting ATPase subunit alpha-1	ATP1A1	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1865-01-01	YEAR INTRODUCED	—	—

ATC classification

ATC code	Therapeutic hierarchy
C01AC01	CARDIOVASCULAR SYSTEM › CARDIAC THERAPY › CARDIAC GLYCOSIDES › Strophanthus glycosides

Chemical structure

• Molecular formula: C₂₉H₄₄O₁₂
• Molecular weight: 584.66 g/mol
• CAS number: —
• InChIKey: LPMXVESGRSUGHW-HBYQJFLCSA-N
• PubChem CID: 439501

C[C@@H]1O[C@@H](O[C@H]2C[C@@H](O)[C@]3(CO)[C@H]4[C@H](O)C[C@]5(C)[C@H](CC[C@]5(O)[C@@H]4CC[C@]3(O)C2)C2=CC(=O)OC2)[C@H](O)[C@H](O)[C@H]1O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Ouabain work?

Its molecular targets in DrugCentral include ATP1A2, STAT3, KCNH2 and ATP1A1.

When was Ouabain first approved?

Ouabain was first approved by the YEAR INTRODUCED in 1865.

What is the chemical formula of Ouabain?

Ouabain has the molecular formula C29H44O12 and a molecular weight of 584.66 g/mol.

Sources

• DrugCentral drug card 2004 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1889436 — compound record and bioactivity
• PubChem CID 439501 — chemical identifiers
• DrugBank DB01092 — drug record
• FDA UNII 5ACL011P69 — substance identity
• UniProt P40763 (STAT3) — target protein
• UniProt Q12809 (KCNH2) — target protein
• UniProt P05023 (ATP1A1) — target protein

How this page is built: methodology · editorial policy & corrections.