Paltusotine

SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS

Key facts

Paltusotine is an onp drug catalogued in DrugCentral. It was first approved by the FDA in 2025. DrugCentral lists 3 molecular targets, including SSTR2, Sstr2 and SSTR4. Recorded indications include Acromegaly.

• Approval status: onp (first approved 2025 by the FDA).
• Molecular targets: SSTR2, Sstr2 and SSTR4 (3 listed in DrugCentral).
• Indications: Acromegaly.
• ATC code: H01CB06 (Somatostatin and analogues).
• Molecular formula: C27H22F2N4O; molecular weight 456.50 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Acromegaly

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Somatostatin receptor type 2	SSTR2	agonist	EC50 9.60
Somatostatin receptor type 2	Sstr2	agonist	EC50 8.92
Somatostatin receptor type 4	SSTR4	unknown	EC50 6.00

Regulatory approvals (2)

Date	Agency	Marketed as	Applicant	Orphan
2026-04-23	EMA	—	Crinetics Pharmaceuticals Europe GmbH	Yes
2025-09-25	FDA	—	Crinetics Pharmaceuticals, Inc.	Yes

ATC classification

ATC code	Therapeutic hierarchy
H01CB06	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES › HYPOTHALAMIC HORMONES › Somatostatin and analogues

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Paltusotine is on its molecule page.

• Molecular formula: C₂₇H₂₂F₂N₄O
• Molecular weight: 456.50 g/mol
• CAS number: —
• InChIKey: GHILNKWBALQPDP-UHFFFAOYSA-N
• PubChem CID: 134168328

C1CN(CCC1N)C2=C3C=C(C=CC3=NC=C2C4=CC(=CC(=C4)F)F)C5=CC=CC(=C5O)C#N

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Paltusotine used for?

DrugCentral lists the following indications for Paltusotine: Acromegaly.

How does Paltusotine work?

Its molecular targets in DrugCentral include SSTR2 (agonist), Sstr2 (agonist) and SSTR4.

When was Paltusotine first approved?

Paltusotine was first approved by the FDA in 2025.

What is the chemical formula of Paltusotine?

Paltusotine has the molecular formula C27H22F2N4O and a molecular weight of 456.50 g/mol.

Sources

• DrugCentral drug card 5784 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL5267842 — compound record and bioactivity
• PubChem CID 134168328 — chemical identifiers
• DrugBank DB16277 — drug record
• FDA UNII F2IBD1GMD3 — substance identity
• DailyMed: FDA labels for Paltusotine — current prescribing information (label search)
• UniProt P30874 (SSTR2) — target protein
• UniProt P31391 (SSTR4) — target protein

How this page is built: methodology · editorial policy & corrections.