Peficitinib

ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

Key facts

Peficitinib is a drug catalogued in DrugCentral. It was first approved by the PMDA in 2019. DrugCentral lists 4 molecular targets, including JAK3, JAK1 and TYK2. Recorded indications include Rheumatoid arthritis.

• Molecular targets: JAK3, JAK1, TYK2 and JAK2 (4 listed in DrugCentral).
• Indications: Rheumatoid arthritis.
• ATC code: L04AF06 (Janus-associated kinase (JAK) inhibitors).
• Molecular formula: C18H22N4O2; molecular weight 326.40 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Rheumatoid arthritis

Contraindications (2)

• Hepatic failure
• Pregnancy

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
Tyrosine-protein kinase JAK3	JAK3	inhibitor	IC50 9.15
Tyrosine-protein kinase JAK1	JAK1	inhibitor	IC50 8.41
Non-receptor tyrosine-protein kinase TYK2	TYK2	inhibitor	IC50 8.32
Tyrosine-protein kinase JAK2	JAK2	inhibitor	IC50 8.30

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2019-03-26	PMDA	—	ASTELLAS PHARMA

ATC classification

ATC code	Therapeutic hierarchy
L04AF06	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › IMMUNOSUPPRESSANTS › IMMUNOSUPPRESSANTS › Janus-associated kinase (JAK) inhibitors

Chemical structure

• Molecular formula: C₁₈H₂₂N₄O₂
• Molecular weight: 326.40 g/mol
• CAS number: 944118-01-8
• InChIKey: DREIJXJRTLTGJC-JQCLMNFQSA-N
• PubChem CID: 57928403

C1[C@@H]2CC3(C[C@@H](C2NC4=C5C=CNC5=NC=C4C(=O)N)CC1C3)O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Peficitinib used for?

DrugCentral lists the following indications for Peficitinib: Rheumatoid arthritis.

How does Peficitinib work?

Its molecular targets in DrugCentral include JAK3 (inhibitor), JAK1 (inhibitor), TYK2 (inhibitor) and JAK2 (inhibitor).

When was Peficitinib first approved?

Peficitinib was first approved by the PMDA in 2019.

What is the chemical formula of Peficitinib?

Peficitinib has the molecular formula C18H22N4O2 and a molecular weight of 326.40 g/mol.

Sources

• DrugCentral drug card 5481 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL3137308 — compound record and bioactivity
• PubChem CID 57928403 — chemical identifiers
• DrugBank DB11708 — drug record
• FDA UNII HPH1166CKX — substance identity
• UniProt P52333 (JAK3) — target protein
• UniProt P23458 (JAK1) — target protein
• UniProt P29597 (TYK2) — target protein
• UniProt O60674 (JAK2) — target protein

How this page is built: methodology · editorial policy & corrections.