Pilsicainide

Drug profile

Key facts

Pilsicainide is a drug catalogued in DrugCentral. DrugCentral lists 2 molecular targets, including KCNH2 and SCN4A. Recorded indications include Tachyarrhythmia.

• Molecular targets: KCNH2 and SCN4A (2 listed in DrugCentral).
• Indications: Tachyarrhythmia.
• Molecular formula: C17H24N2O; molecular weight 272.39 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Tachyarrhythmia

Mechanism & targets

Molecular targets (2)

Target	Gene	Action	Activity
Potassium voltage-gated channel subfamily H member 2	KCNH2	unknown	IC50 4.69
Sodium channel protein type 4 subunit alpha	SCN4A	blocker	IC50 4.38

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Cerebral infarction	83.3
Cardiac failure	47.7
Renal impairment	44.8
Atrial fibrillation	44.6
Cardiac tamponade	43.7
Interstitial lung disease	39.1

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Pilsicainide is on its molecule page.

• Molecular formula: C₁₇H₂₄N₂O
• Molecular weight: 272.39 g/mol
• CAS number: 88069-67-4
• InChIKey: BCQTVJKBTWGHCX-UHFFFAOYSA-N
• PubChem CID: 4820

CC1=CC=CC(C)=C1NC(=O)CC12CCCN1CCC2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Pilsicainide used for?

DrugCentral lists the following indications for Pilsicainide: Tachyarrhythmia.

How does Pilsicainide work?

Its molecular targets in DrugCentral include KCNH2 and SCN4A (blocker).

What is the chemical formula of Pilsicainide?

Pilsicainide has the molecular formula C17H24N2O and a molecular weight of 272.39 g/mol.

Sources

• DrugCentral drug card 2167 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL163238 — compound record and bioactivity
• PubChem CID 4820 — chemical identifiers
• DrugBank DB12712 — drug record
• FDA UNII AV0X7V6CSE — substance identity
• UniProt Q12809 (KCNH2) — target protein
• UniProt P35499 (SCN4A) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.