Pinacidil

CARDIOVASCULAR SYSTEM

Key facts

Pinacidil is an ofm drug catalogued in DrugCentral. DrugCentral lists 3 molecular targets, including ABCC9|KCNJ11, ABCC9 and KCNMA1. Recorded indications include Hypertensive disorder.

• Approval status: ofm.
• Molecular targets: ABCC9|KCNJ11, ABCC9 and KCNMA1 (3 listed in DrugCentral).
• Indications: Hypertensive disorder.
• ATC code: C02DG01 (Guanidine derivatives).
• Molecular formula: C13H19N5; molecular weight 245.33 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Hypertensive disorder

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Sulfonylurea receptor 2, Kir6.2	ABCC9|KCNJ11	opener	Ki 6.49
ATP-binding cassette sub-family C member 9	ABCC9	unknown	EC50 5.45
Calcium-activated potassium channel subunit alpha-1	KCNMA1	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	LEO PHARM

ATC classification

ATC code	Therapeutic hierarchy
C02DG01	CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON › Guanidine derivatives
C02LX01	CARDIOVASCULAR SYSTEM › ANTIHYPERTENSIVES › ANTIHYPERTENSIVES AND DIURETICS IN COMBINATION › Other antihypertensives and diuretics

Chemical structure

• Molecular formula: C₁₃H₁₉N₅
• Molecular weight: 245.33 g/mol
• CAS number: 60560-33-0
• InChIKey: IVVNZDGDKPTYHK-UHFFFAOYSA-N
• PubChem CID: 55329

CC(NC(NC1=CC=NC=C1)=NC#N)C(C)(C)C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Pinacidil used for?

DrugCentral lists the following indications for Pinacidil: Hypertensive disorder.

How does Pinacidil work?

Its molecular targets in DrugCentral include ABCC9|KCNJ11 (opener), ABCC9 and KCNMA1.

What is the chemical formula of Pinacidil?

Pinacidil has the molecular formula C13H19N5 and a molecular weight of 245.33 g/mol.

Sources

• DrugCentral drug card 2173 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1159 — compound record and bioactivity
• PubChem CID 55329 — chemical identifiers
• DrugBank DB06762 — drug record
• FDA UNII 7B0ZZH8P2W — substance identity
• DailyMed: FDA labels for Pinacidil — current prescribing information (label search)
• UniProt O60706 (ABCC9) — target protein
• UniProt Q12791 (KCNMA1) — target protein

How this page is built: methodology · editorial policy & corrections.