Pirfenidone

Pyridone — ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

Key facts

Pirfenidone is an ofp drug in the Pyridone class catalogued in DrugCentral. It was first approved by the PMDA in 2008. Recorded indications include Idiopathic pulmonary fibrosis.

• Approval status: ofp (first approved 2008 by the PMDA).
• Drug class: Pyridone.
• Indications: Idiopathic pulmonary fibrosis.
• ATC code: L04AX05 (Other immunosuppressants).
• Molecular formula: C12H11NO; molecular weight 185.23 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Idiopathic pulmonary fibrosis

Contraindications (5)

• End stage liver disease
• End stage renal failure
• Fluvoxamine
• Severe hepatic impairment
• Severe renal impairment

Mechanism & targets

• Established pharmacologic class: Pyridone

Regulatory approvals (3)

Date	Agency	Marketed as	Applicant	Orphan
2014-10-15	FDA	—	GENENTECH INC
2011-02-28	EMA	—	Roche Registration Limited	Yes
2008-09-16	PMDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
L04AX05	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › IMMUNOSUPPRESSANTS › IMMUNOSUPPRESSANTS › Other immunosuppressants

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Death	4612.7
Decreased appetite	1001.7
Photosensitivity reaction	848.6
Nausea	665.6
Weight decreased	541.7
Pulmonary function test decreased	458.4
Dyspnoea	457.7
Cough	431.9
Pulmonary function test abnormal	416.3
Forced vital capacity decreased	376.3
No adverse event	360.1
Oxygen saturation decreased	352.3

Chemical structure

• Molecular formula: C₁₂H₁₁NO
• Molecular weight: 185.23 g/mol
• CAS number: 53179-13-8
• InChIKey: ISWRGOKTTBVCFA-UHFFFAOYSA-N
• PubChem CID: 40632

CC1=CN(C(=O)C=C1)C1=CC=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Pirfenidone used for?

DrugCentral lists the following indications for Pirfenidone: Idiopathic pulmonary fibrosis.

When was Pirfenidone first approved?

Pirfenidone was first approved by the PMDA in 2008.

What drug class does Pirfenidone belong to?

Pirfenidone is in the Pyridone class.

What is the chemical formula of Pirfenidone?

Pirfenidone has the molecular formula C12H11NO and a molecular weight of 185.23 g/mol.

Sources

• DrugCentral drug card 4224 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1256391 — compound record and bioactivity
• PubChem CID 40632 — chemical identifiers
• DrugBank DB04951 — drug record
• FDA UNII D7NLD2JX7U — substance identity
• DailyMed: FDA labels for Pirfenidone — current prescribing information (label search)
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.