Salsalate
NERVOUS SYSTEM
Also known as: disalicylic acid, salicyl salicylate, salicylic acid salicylate, salicyloxysalicylic acid, salicyloylsalicylic acid, salicylsalicylic acid, sasapyrine
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Salsalate is a drug catalogued in DrugCentral. Recorded indications include Osteoarthritis and Rheumatoid arthritis.
- Indications: Osteoarthritis and Rheumatoid arthritis.
- ATC code: N02BA06 (Salicylic acid and derivatives).
- Molecular formula: C14H10O5; molecular weight 258.23 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (2)
- Osteoarthritis
- Rheumatoid arthritis
Contraindications (22)
- Anemia
- Anemia due to enzyme deficiency
- Blood coagulation disorder
- Body fluid retention
- Breastfeeding (mother)
- Cardiovascular event risk
- Diabetes mellitus
- Disease of liver
- Disorder of cardiovascular system
- Factor II deficiency
- Gastritis
- Gastroesophageal reflux disease
- Gastrointestinal hemorrhage
- Gastrointestinal ulcer
- Hemophilia
- Hepatic failure
- Kidney disease
- Nasal polyp
- Pregnancy, function
- Thrombotic thrombocytopenic purpura
- Thyrotoxicosis
- Vitamin K deficiency
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| — | FDA | — | — |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
N02BA06 | NERVOUS SYSTEM › ANALGESICS › OTHER ANALGESICS AND ANTIPYRETICS › Salicylic acid and derivatives |
Reported adverse-event signals
Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.
| MedDRA term | LLR |
|---|---|
| International normalised ratio increased | 44.9 |
| Drug hypersensitivity | 25.0 |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Salsalate is on its molecule page.
| Molecular formula | C14H10O5 |
|---|---|
| Molecular weight | 258.23 g/mol |
| CAS number | 552-94-3 |
| InChIKey | WVYADZUPLLSGPU-UHFFFAOYSA-N |
| PubChem CID | 338 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Salsalate used for?
DrugCentral lists the following indications for Salsalate: Osteoarthritis and Rheumatoid arthritis.
What is the chemical formula of Salsalate?
Salsalate has the molecular formula C14H10O5 and a molecular weight of 258.23 g/mol.
Browse: all drugs starting with S · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 2420 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL154111 — compound record and bioactivity
- PubChem CID 338 — chemical identifiers
- DrugBank DB00936 — drug record
- FDA UNII V9MO595C9I — substance identity
- DailyMed: FDA labels for Salsalate — current prescribing information (label search)
- FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
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