Serine

Drug profile

Key facts

Serine is a drug catalogued in DrugCentral. DrugCentral lists 6 molecular targets, including ache, BCHE and Slc7a10. Recorded indications include Acute tuberculosis, Bacterial urinary infection, Escherichia coli urinary tract infection and Open-angle glaucoma.

• Molecular targets: ache, BCHE, Slc7a10 and ACHE (6 listed in DrugCentral).
• Indications: Acute tuberculosis, Bacterial urinary infection, Escherichia coli urinary tract infection, Open-angle glaucoma and Pulmonary tuberculosis.
• Molecular formula: C3H7NO3; molecular weight 105.09 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (5)

• Acute tuberculosis
• Bacterial urinary infection
• Escherichia coli urinary tract infection
• Open-angle glaucoma
• Pulmonary tuberculosis

Off-label uses (4)

• Angle-closure glaucoma
• Mycobacteriosis
• Secondary glaucoma
• Tuberculosis of meninges

Contraindications (23)

• Acute nephropathy
• Alcoholism
• Classical phenylketonuria
• CNS Toxicity
• Cobalamin deficiency
• Depressive disorder
• Diabetes mellitus
• End stage renal disease
• Epilepsy
• Folic acid deficiency
• Heart disease
• Humoral hypercalcemia of malignancy
• Hypercalcemia
• Hypercalciuria
• Kidney disease
• Kidney stone
• Megaloblastic anemia
• Poisoning by digitalis glycoside
• Psychotic disorder
• Sarcoidosis
• Severe anxiety (panic)
• Sideroblastic anemia
• Ventricular fibrillation

Mechanism & targets

Molecular targets (6)

Target	Gene	Action	Activity
Acetylcholinesterase	ache	unknown	IC50 7.82
Cholinesterase	BCHE	unknown	IC50 7.80
Asc-type amino acid transporter 1	Slc7a10	unknown	IC50 5.02
Acetylcholinesterase	ACHE	unknown	IC50 4.42
Gamma-glutamyltranspeptidase 1	Ggt1	unknown	Ki 4.30
Amino acid transporter	Slc1a5	unknown	IC50 4.24

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	—

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Foetal growth restriction	70.8
Device related sepsis	50.8

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Serine is on its molecule page.

• Molecular formula: C₃H₇NO₃
• Molecular weight: 105.09 g/mol
• CAS number: —
• InChIKey: MTCFGRXMJLQNBG-REOHCLBHSA-N
• PubChem CID: 5951

N[C@@H](CO)C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Serine used for?

DrugCentral lists the following indications for Serine: Acute tuberculosis, Bacterial urinary infection, Escherichia coli urinary tract infection, Open-angle glaucoma and Pulmonary tuberculosis.

How does Serine work?

Its molecular targets in DrugCentral include ache, BCHE, Slc7a10 and ACHE.

What is the chemical formula of Serine?

Serine has the molecular formula C3H7NO3 and a molecular weight of 105.09 g/mol.

Sources

• DrugCentral drug card 4127 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL11298 — compound record and bioactivity
• PubChem CID 5951 — chemical identifiers
• DrugBank DB00133 — drug record
• FDA UNII 452VLY9402 — substance identity
• DailyMed: FDA labels for Serine — current prescribing information (label search)
• UniProt P22303 (ACHE) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.