Silicon dioxide
Drug profile
Also known as: silica, silica gel
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Silicon dioxide is a drug catalogued in DrugCentral. Recorded indications include Flatulence symptom, Gastric Hypersecretory Conditions, Gastroesophageal reflux disease and Gastrointestinal Radiography Adjunct.
- Indications: Flatulence symptom, Gastric Hypersecretory Conditions, Gastroesophageal reflux disease, Gastrointestinal Radiography Adjunct and Heartburn and others.
- Molecular formula: O2Si; molecular weight 60.08 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (8)
- Flatulence symptom
- Gastric Hypersecretory Conditions
- Gastroesophageal reflux disease
- Gastrointestinal Radiography Adjunct
- Heartburn
- Hiatal Hernia with Reflux Esophagitis
- Indigestion
- Peptic ulcer
Off-label uses (3)
- Multiple endocrine adenomas
- Stress-Related GI Mucosal Bleeding Prevention
- Systemic mast cell disease
Contraindications (13)
- Acute nephropathy
- Aluminum intoxication
- Chronic diarrhea
- Chronic heart failure
- Constipation
- Diarrhea
- Edema
- Fecal impaction
- Gastrointestinal obstruction
- Hemorrhoids
- Hypophosphatemia
- Kidney disease
- Oliguria
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| — | FDA | — | — |
Reported adverse-event signals
Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.
| MedDRA term | LLR |
|---|---|
| Febrile neutropenia | 205.5 |
| Hepatic function abnormal | 121.1 |
| Myelosuppression | 104.9 |
| Platelet count decreased | 88.4 |
| Exposure to toxic agent | 59.7 |
| Neutrophil count decreased | 58.6 |
| Acute myeloid leukaemia | 51.7 |
| Death | 39.1 |
| CADASIL | 37.0 |
| Pneumonia | 34.1 |
| Visual evoked potentials abnormal | 32.4 |
| Liver disorder | 32.0 |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Silicon dioxide is on its molecule page.
| Molecular formula | O2Si |
|---|---|
| Molecular weight | 60.08 g/mol |
| CAS number | 7631-86-9 |
| InChIKey | VYPSYNLAJGMNEJ-UHFFFAOYSA-N |
| PubChem CID | 24261 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Silicon dioxide used for?
DrugCentral lists the following indications for Silicon dioxide: Flatulence symptom, Gastric Hypersecretory Conditions, Gastroesophageal reflux disease, Gastrointestinal Radiography Adjunct, Heartburn, Hiatal Hernia with Reflux Esophagitis, Indigestion and Peptic ulcer.
What is the chemical formula of Silicon dioxide?
Silicon dioxide has the molecular formula O2Si and a molecular weight of 60.08 g/mol.
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Sources
- DrugCentral drug card 4284 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL2108563 — compound record and bioactivity
- PubChem CID 24261 — chemical identifiers
- DrugBank DB11132 — drug record
- FDA UNII ETJ7Z6XBU4 — substance identity
- DailyMed: FDA labels for Silicon dioxide — current prescribing information (label search)
- FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral
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