Tonzonium

Drug profile

Key facts

Tonzonium is an ofp drug catalogued in DrugCentral. It was first approved by the FDA in 1962. DrugCentral lists 2 molecular targets, including Dyrk1a and IDE. Recorded indications include Mastoidectomy Cavity Infections and Otitis externa.

• Approval status: ofp (first approved 1962 by the FDA).
• Molecular targets: Dyrk1a and IDE (2 listed in DrugCentral).
• Indications: Mastoidectomy Cavity Infections and Otitis externa.
• Molecular formula: C32H55N4O; molecular weight 511.82 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (2)

• Mastoidectomy Cavity Infections
• Otitis externa

Off-label uses (1)

• Chronic purulent otitis media

Contraindications (7)

• Bullous myringitis
• Fungal ear infection
• Herpes simplex
• Herpes zoster auricularis
• Perforation of tympanic membrane
• Tuberculosis of ear
• Viral ear infection

Mechanism & targets

Molecular targets (2)

Target	Gene	Action	Activity
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Dyrk1a	unknown	AC50 5.03
Insulin-degrading enzyme	IDE	unknown	EC50 4.27

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1962-05-17	FDA	—	PAR STERILE PRODUCTS

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Tonzonium is on its molecule page.

• Molecular formula: C₃₂H₅₅N₄O
• Molecular weight: 511.82 g/mol
• CAS number: 553-08-2
• InChIKey: IOYZYMQFUSNATM-UHFFFAOYSA-N
• PubChem CID: 5456

CCCCCCCCCCCCCCCC[N+](C)(C)CCN(CC1=CC=C(OC)C=C1)C1=NC=CC=N1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Tonzonium used for?

DrugCentral lists the following indications for Tonzonium: Mastoidectomy Cavity Infections and Otitis externa.

How does Tonzonium work?

Its molecular targets in DrugCentral include Dyrk1a and IDE.

When was Tonzonium first approved?

Tonzonium was first approved by the FDA in 1962.

What is the chemical formula of Tonzonium?

Tonzonium has the molecular formula C32H55N4O and a molecular weight of 511.82 g/mol.

Sources

• DrugCentral drug card 4605 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200883 — compound record and bioactivity
• PubChem CID 5456 — chemical identifiers
• DrugBank DB09552 — drug record
• FDA UNII JI2B19CR0R — substance identity
• DailyMed: FDA labels for Tonzonium — current prescribing information (label search)
• UniProt P14735 (IDE) — target protein

How this page is built: methodology · editorial policy & corrections.