2,6-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]benzamide;3,5-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]pyridine-4-carboxamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-methyl-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide

C114H92F16N16O6S6 — CID 157393582

About 2,6-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]benzamide;3,5-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]pyridine-4-carboxamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-methyl-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide

2,6-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]benzamide;3,5-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]pyridine-4-carboxamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-methyl-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide (PubChem CID 157393582) has the molecular formula C114H92F16N16O6S6 and a molecular weight of 2278.47 g/mol. Its IUPAC name is 2,6-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]benzamide;3,5-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]pyridine-4-carboxamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-methyl-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide.

Molecular Properties

• Compound Name: 2,6-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]benzamide;3,5-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]pyridine-4-carboxamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-methyl-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide
• PubChem CID: 157393582
• Molecular Formula: C114H92F16N16O6S6
• Molecular Weight: 2278.47 g/mol
• Exact Mass: 2276.55
• IUPAC Name: 2,6-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]benzamide;3,5-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]pyridine-4-carboxamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-methyl-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide
• SMILES: Cc1ccccc1C(=O)Nc1ccc(-c2c(C(F)(F)F)sc3c2CCC3)cn1.Cc1sc2c(c1-c1cnc(NC(=O)C(C)C)cn1)CCC2.Cc1sc2c(c1-c1cnc(NC(=O)c3c(F)cccc3F)cn1)CCC2.Cc1sc2c(c1-c1cnc(NC(=O)c3c(F)cncc3F)cn1)CCC2.O=C(Nc1ccc(-c2c(C(F)(F)F)sc3c2CCC3)cn1)c1c(F)cccc1F.O=C(Nc1ccc(-c2c(C(F)(F)F)sc3c2CCC3)cn1)c1ccccc1F
• InChI: InChI=1S/C21H17F3N2OS.C20H13F5N2OS.C20H14F4N2OS.C19H15F2N3OS.C18H14F2N4OS.C16H19N3OS/c1-12-5-2-3-6-14(12)20(27)26-17-10-9-13(11-25-17)18-15-7-4-8-16(15)28-19(18)21(22,23)24;21-12-4-2-5-13(22)17(12)19(28)27-15-8-7-10(9-26-15)16-11-3-1-6-14(11)29-18(16)20(23,24)25;21-14-6-2-1-4-12(14)19(27)26-16-9-8-11(10-25-16)17-13-5-3-7-15(13)28-18(17)20(22,23)24;1-10-17(11-4-2-7-15(11)26-10)14-8-23-16(9-22-14)24-19(25)18-12(20)5-3-6-13(18)21;1-9-16(10-3-2-4-14(10)26-9)13-7-23-15(8-22-13)24-18(25)17-11(19)5-21-6-12(17)20;1-9(2)16(20)19-14-8-17-12(7-18-14)15-10(3)21-13-6-4-5-11(13)15/h2-3,5-6,9-11H,4,7-8H2,1H3,(H,25,26,27);2,4-5,7-9H,1,3,6H2,(H,26,27,28);1-2,4,6,8-10H,3,5,7H2,(H,25,26,27);3,5-6,8-9H,2,4,7H2,1H3,(H,23,24,25);5-8H,2-4H2,1H3,(H,23,24,25);7-9H,4-6H2,1-3H3,(H,18,19,20)
• InChIKey: BMHOZGHQFQNUTA-UHFFFAOYSA-N
• XLogP: 29.49
• TPSA: 303.50 Ų
• H-Bond Donors: 6
• H-Bond Acceptors: 22
• Rotatable Bonds: 18
• Heavy Atoms: 158
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2278.47
LogP ≤ 5	29.49
H-Bond Donors ≤ 5	6
H-Bond Acceptors ≤ 10	22

Frequently Asked Questions

What is the IUPAC name of 2,6-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]benzamide;3,5-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]pyridine-4-carboxamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-methyl-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide?

The IUPAC name of 2,6-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]benzamide;3,5-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]pyridine-4-carboxamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-methyl-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide (CID 157393582) is 2,6-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]benzamide;3,5-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]pyridine-4-carboxamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-methyl-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide.

What is the SMILES notation for 2,6-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]benzamide;3,5-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]pyridine-4-carboxamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-methyl-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide?

The canonical SMILES for 2,6-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]benzamide;3,5-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]pyridine-4-carboxamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-methyl-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide is Cc1ccccc1C(=O)Nc1ccc(-c2c(C(F)(F)F)sc3c2CCC3)cn1.Cc1sc2c(c1-c1cnc(NC(=O)C(C)C)cn1)CCC2.Cc1sc2c(c1-c1cnc(NC(=O)c3c(F)cccc3F)cn1)CCC2.Cc1sc2c(c1-c1cnc(NC(=O)c3c(F)cncc3F)cn1)CCC2.O=C(Nc1ccc(-c2c(C(F)(F)F)sc3c2CCC3)cn1)c1c(F)cccc1F.O=C(Nc1ccc(-c2c(C(F)(F)F)sc3c2CCC3)cn1)c1ccccc1F.

What is the InChIKey of 2,6-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]benzamide;3,5-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]pyridine-4-carboxamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-methyl-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide?

The InChIKey is BMHOZGHQFQNUTA-UHFFFAOYSA-N. The full InChI is InChI=1S/C21H17F3N2OS.C20H13F5N2OS.C20H14F4N2OS.C19H15F2N3OS.C18H14F2N4OS.C16H19N3OS/c1-12-5-2-3-6-14(12)20(27)26-17-10-9-13(11-25-17)18-15-7-4-8-16(15)28-19(18)21(22,23)24;21-12-4-2-5-13(22)17(12)19(28)27-15-8-7-10(9-26-15)16-11-3-1-6-14(11)29-18(16)20(23,24)25;21-14-6-2-1-4-12(14)19(27)26-16-9-8-11(10-25-16)17-13-5-3-7-15(13)28-18(17)20(22,23)24;1-10-17(11-4-2-7-15(11)26-10)14-8-23-16(9-22-14)24-19(25)18-12(20)5-3-6-13(18)21;1-9-16(10-3-2-4-14(10)26-9)13-7-23-15(8-22-13)24-18(25)17-11(19)5-21-6-12(17)20;1-9(2)16(20)19-14-8-17-12(7-18-14)15-10(3)21-13-6-4-5-11(13)15/h2-3,5-6,9-11H,4,7-8H2,1H3,(H,25,26,27);2,4-5,7-9H,1,3,6H2,(H,26,27,28);1-2,4,6,8-10H,3,5,7H2,(H,25,26,27);3,5-6,8-9H,2,4,7H2,1H3,(H,23,24,25);5-8H,2-4H2,1H3,(H,23,24,25);7-9H,4-6H2,1-3H3,(H,18,19,20).

What are the key properties of 2,6-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]benzamide;3,5-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]pyridine-4-carboxamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-methyl-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide?

2,6-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]benzamide;3,5-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]pyridine-4-carboxamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-methyl-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide has a molecular weight of 2278.47 g/mol, XLogP of 29.49, 18 rotatable bonds, 6 hydrogen bond donors, and 22 hydrogen bond acceptors.

Where does this data come from?

All data for 2,6-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]benzamide;3,5-difluoro-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]pyridine-4-carboxamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-methyl-N-[5-(2-methyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide is sourced from PubChem (CID 157393582), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).