2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]propanamide

C111H87F23N16O6S6 — CID 157488338

About 2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]propanamide

2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]propanamide (PubChem CID 157488338) has the molecular formula C111H87F23N16O6S6 and a molecular weight of 2370.38 g/mol. Its IUPAC name is 2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]propanamide.

Molecular Properties

• Compound Name: 2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]propanamide
• PubChem CID: 157488338
• Molecular Formula: C111H87F23N16O6S6
• Molecular Weight: 2370.38 g/mol
• Exact Mass: 2368.50
• IUPAC Name: 2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]propanamide
• SMILES: CC(C)C(=O)Nc1ccc(-c2c(C(F)(F)F)sc3c2CCC3)cn1.CC(C)C(=O)Nc1cnc(-c2c(C(F)(F)F)sc3c2CCC3)cn1.Cc1ccccc1C(=O)Nc1cnc(-c2c(C(F)(F)F)sc3c2CCC3)cn1.O=C(Nc1ccc(-c2c(C(F)(F)F)sc3c2CCC3)cn1)c1c(F)cccc1F.O=C(Nc1cnc(-c2c(C(F)(F)F)sc3c2CCC3)cn1)c1c(F)cccc1F.O=C(Nc1cnc(-c2c(C(F)(F)F)sc3c2CCC3)cn1)c1ccccc1F
• InChI: InChI=1S/C20H13F5N2OS.C20H16F3N3OS.C19H12F5N3OS.C19H13F4N3OS.C17H17F3N2OS.C16H16F3N3OS/c21-12-4-2-5-13(22)17(12)19(28)27-15-8-7-10(9-26-15)16-11-3-1-6-14(11)29-18(16)20(23,24)25;1-11-5-2-3-6-12(11)19(27)26-16-10-24-14(9-25-16)17-13-7-4-8-15(13)28-18(17)20(21,22)23;20-10-4-2-5-11(21)16(10)18(28)27-14-8-25-12(7-26-14)15-9-3-1-6-13(9)29-17(15)19(22,23)24;20-12-6-2-1-4-10(12)18(27)26-15-9-24-13(8-25-15)16-11-5-3-7-14(11)28-17(16)19(21,22)23;1-9(2)16(23)22-13-7-6-10(8-21-13)14-11-4-3-5-12(11)24-15(14)17(18,19)20;1-8(2)15(23)22-12-7-20-10(6-21-12)13-9-4-3-5-11(9)24-14(13)16(17,18)19/h2,4-5,7-9H,1,3,6H2,(H,26,27,28);2-3,5-6,9-10H,4,7-8H2,1H3,(H,25,26,27);2,4-5,7-8H,1,3,6H2,(H,26,27,28);1-2,4,6,8-9H,3,5,7H2,(H,25,26,27);6-9H,3-5H2,1-2H3,(H,21,22,23);6-8H,3-5H2,1-2H3,(H,21,22,23)
• InChIKey: BWYZRURFGGDNRV-UHFFFAOYSA-N
• XLogP: 30.69
• TPSA: 303.50 Ų
• H-Bond Donors: 6
• H-Bond Acceptors: 22
• Rotatable Bonds: 18
• Heavy Atoms: 162
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2370.38
LogP ≤ 5	30.69
H-Bond Donors ≤ 5	6
H-Bond Acceptors ≤ 10	22

Frequently Asked Questions

What is the IUPAC name of 2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]propanamide?

The IUPAC name of 2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]propanamide (CID 157488338) is 2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]propanamide.

What is the SMILES notation for 2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]propanamide?

The canonical SMILES for 2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]propanamide is CC(C)C(=O)Nc1ccc(-c2c(C(F)(F)F)sc3c2CCC3)cn1.CC(C)C(=O)Nc1cnc(-c2c(C(F)(F)F)sc3c2CCC3)cn1.Cc1ccccc1C(=O)Nc1cnc(-c2c(C(F)(F)F)sc3c2CCC3)cn1.O=C(Nc1ccc(-c2c(C(F)(F)F)sc3c2CCC3)cn1)c1c(F)cccc1F.O=C(Nc1cnc(-c2c(C(F)(F)F)sc3c2CCC3)cn1)c1c(F)cccc1F.O=C(Nc1cnc(-c2c(C(F)(F)F)sc3c2CCC3)cn1)c1ccccc1F.

What is the InChIKey of 2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]propanamide?

The InChIKey is BWYZRURFGGDNRV-UHFFFAOYSA-N. The full InChI is InChI=1S/C20H13F5N2OS.C20H16F3N3OS.C19H12F5N3OS.C19H13F4N3OS.C17H17F3N2OS.C16H16F3N3OS/c21-12-4-2-5-13(22)17(12)19(28)27-15-8-7-10(9-26-15)16-11-3-1-6-14(11)29-18(16)20(23,24)25;1-11-5-2-3-6-12(11)19(27)26-16-10-24-14(9-25-16)17-13-7-4-8-15(13)28-18(17)20(21,22)23;20-10-4-2-5-11(21)16(10)18(28)27-14-8-25-12(7-26-14)15-9-3-1-6-13(9)29-17(15)19(22,23)24;20-12-6-2-1-4-10(12)18(27)26-15-9-24-13(8-25-15)16-11-5-3-7-14(11)28-17(16)19(21,22)23;1-9(2)16(23)22-13-7-6-10(8-21-13)14-11-4-3-5-12(11)24-15(14)17(18,19)20;1-8(2)15(23)22-12-7-20-10(6-21-12)13-9-4-3-5-11(9)24-14(13)16(17,18)19/h2,4-5,7-9H,1,3,6H2,(H,26,27,28);2-3,5-6,9-10H,4,7-8H2,1H3,(H,25,26,27);2,4-5,7-8H,1,3,6H2,(H,26,27,28);1-2,4,6,8-9H,3,5,7H2,(H,25,26,27);6-9H,3-5H2,1-2H3,(H,21,22,23);6-8H,3-5H2,1-2H3,(H,21,22,23).

What are the key properties of 2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]propanamide?

2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]propanamide has a molecular weight of 2370.38 g/mol, XLogP of 30.69, 18 rotatable bonds, 6 hydrogen bond donors, and 22 hydrogen bond acceptors.

Where does this data come from?

All data for 2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2,6-difluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]benzamide;2-fluoro-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]benzamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]pyrazin-2-yl]propanamide;2-methyl-N-[5-[2-(trifluoromethyl)-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl]-2-pyridinyl]propanamide is sourced from PubChem (CID 157488338), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).