4-[1-[3-(1,1-difluoroethyl)-1-methylpyrazol-5-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3,5-difluorophenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide

C144H165F16N37O24S11 — CID 158517483

IUPAC4-[1-[3-(1,1-difluoroethyl)-1-methylpyrazol-5-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3,5-difluorophenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide
SMILESC#Cc1ccc(S(=O)(=O)C(C)(F)C2CCN(C(=O)Nc3ccnnc3)CC2)cc1.C#Cc1ccc(S(=O)(=O)C(C)(F)C2CCN(C(=O)Nc3cnns3)CC2)cc1.C#Cc1cccc(S(=O)(=O)C(C)(F)C2CCN(C(=O)Nc3ccnnc3)CC2)c1.CC(F)(C1CCN(C(=O)Nc2ccnnc2)CC1)S(=O)(=O)c1cc(F)cc(F)c1.CC(F)(F)c1ccc(S(=O)(=O)C(C)(F)C2CCN(C(=O)Nc3cnns3)CC2)cc1.Cn1cc(S(=O)(=O)C(C)(F)C2CCN(C(=O)Nc3ccnnc3)CC2)c(C(F)F)n1.Cn1cccc1S(=O)(=O)C(C)(F)C1CCN(C(=O)Nc2cnns2)CC1.Cn1nc(C(C)(F)F)cc1S(=O)(=O)C(C)(F)C1CCN(C(=O)Nc2ccnnc2)CC1
InChIInChI=1S/2C20H21FN4O3S.C18H23F3N6O3S.C18H21F3N4O3S2.C18H19F3N4O3S.C18H19FN4O3S2.C17H21F3N6O3S.C15H20FN5O3S2/c1-3-15-4-6-18(7-5-15)29(27,28)20(2,21)16-9-12-25(13-10-16)19(26)24-17-8-11-22-23-14-17;1-3-15-5-4-6-18(13-15)29(27,28)20(2,21)16-8-11-25(12-9-16)19(26)24-17-7-10-22-23-14-17;1-17(19,20)14-10-15(26(3)25-14)31(29,30)18(2,21)12-5-8-27(9-6-12)16(28)24-13-4-7-22-23-11-13;1-17(19,20)12-3-5-14(6-4-12)30(27,28)18(2,21)13-7-9-25(10-8-13)16(26)23-15-11-22-24-29-15;1-18(21,29(27,28)16-9-13(19)8-14(20)10-16)12-3-6-25(7-4-12)17(26)24-15-2-5-22-23-11-15;1-3-13-4-6-15(7-5-13)28(25,26)18(2,19)14-8-10-23(11-9-14)17(24)21-16-12-20-22-27-16;1-17(20,30(28,29)13-10-25(2)24-14(13)15(18)19)11-4-7-26(8-5-11)16(27)23-12-3-6-21-22-9-12;1-15(16,26(23,24)13-4-3-7-20(13)2)11-5-8-21(9-6-11)14(22)18-12-10-17-19-25-12/h1,4-8,11,14,16H,9-10,12-13H2,2H3,(H,22,24,26);1,4-7,10,13-14,16H,8-9,11-12H2,2H3,(H,22,24,26);4,7,10-12H,5-6,8-9H2,1-3H3,(H,22,24,28);3-6,11,13H,7-10H2,1-2H3,(H,23,26);2,5,8-12H,3-4,6-7H2,1H3,(H,22,24,26);1,4-7,12,14H,8-11H2,2H3,(H,21,24);3,6,9-11,15H,4-5,7-8H2,1-2H3,(H,21,23,27);3-4,7,10-11H,5-6,8-9H2,1-2H3,(H,18,22)
InChIKeyHLUPHYGKTNKBNT-UHFFFAOYSA-N
MW3454.84 g/mol
LogP23.41
Rot. Bonds35

About 4-[1-[3-(1,1-difluoroethyl)-1-methylpyrazol-5-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3,5-difluorophenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide

4-[1-[3-(1,1-difluoroethyl)-1-methylpyrazol-5-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3,5-difluorophenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide (PubChem CID 158517483) has the molecular formula C144H165F16N37O24S11 and a molecular weight of 3454.84 g/mol. Its IUPAC name is 4-[1-[3-(1,1-difluoroethyl)-1-methylpyrazol-5-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3,5-difluorophenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide.

Molecular Properties

Compound Name4-[1-[3-(1,1-difluoroethyl)-1-methylpyrazol-5-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3,5-difluorophenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide
PubChem CID158517483
Molecular FormulaC144H165F16N37O24S11
Molecular Weight3454.84 g/mol
Exact Mass3451.95
IUPAC Name4-[1-[3-(1,1-difluoroethyl)-1-methylpyrazol-5-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3,5-difluorophenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide
SMILESC#Cc1ccc(S(=O)(=O)C(C)(F)C2CCN(C(=O)Nc3ccnnc3)CC2)cc1.C#Cc1ccc(S(=O)(=O)C(C)(F)C2CCN(C(=O)Nc3cnns3)CC2)cc1.C#Cc1cccc(S(=O)(=O)C(C)(F)C2CCN(C(=O)Nc3ccnnc3)CC2)c1.CC(F)(C1CCN(C(=O)Nc2ccnnc2)CC1)S(=O)(=O)c1cc(F)cc(F)c1.CC(F)(F)c1ccc(S(=O)(=O)C(C)(F)C2CCN(C(=O)Nc3cnns3)CC2)cc1.Cn1cc(S(=O)(=O)C(C)(F)C2CCN(C(=O)Nc3ccnnc3)CC2)c(C(F)F)n1.Cn1cccc1S(=O)(=O)C(C)(F)C1CCN(C(=O)Nc2cnns2)CC1.Cn1nc(C(C)(F)F)cc1S(=O)(=O)C(C)(F)C1CCN(C(=O)Nc2ccnnc2)CC1
InChIInChI=1S/2C20H21FN4O3S.C18H23F3N6O3S.C18H21F3N4O3S2.C18H19F3N4O3S.C18H19FN4O3S2.C17H21F3N6O3S.C15H20FN5O3S2/c1-3-15-4-6-18(7-5-15)29(27,28)20(2,21)16-9-12-25(13-10-16)19(26)24-17-8-11-22-23-14-17;1-3-15-5-4-6-18(13-15)29(27,28)20(2,21)16-8-11-25(12-9-16)19(26)24-17-7-10-22-23-14-17;1-17(19,20)14-10-15(26(3)25-14)31(29,30)18(2,21)12-5-8-27(9-6-12)16(28)24-13-4-7-22-23-11-13;1-17(19,20)12-3-5-14(6-4-12)30(27,28)18(2,21)13-7-9-25(10-8-13)16(26)23-15-11-22-24-29-15;1-18(21,29(27,28)16-9-13(19)8-14(20)10-16)12-3-6-25(7-4-12)17(26)24-15-2-5-22-23-11-15;1-3-13-4-6-15(7-5-13)28(25,26)18(2,19)14-8-10-23(11-9-14)17(24)21-16-12-20-22-27-16;1-17(20,30(28,29)13-10-25(2)24-14(13)15(18)19)11-4-7-26(8-5-11)16(27)23-12-3-6-21-22-9-12;1-15(16,26(23,24)13-4-3-7-20(13)2)11-5-8-21(9-6-11)14(22)18-12-10-17-19-25-12/h1,4-8,11,14,16H,9-10,12-13H2,2H3,(H,22,24,26);1,4-7,10,13-14,16H,8-9,11-12H2,2H3,(H,22,24,26);4,7,10-12H,5-6,8-9H2,1-3H3,(H,22,24,28);3-6,11,13H,7-10H2,1-2H3,(H,23,26);2,5,8-12H,3-4,6-7H2,1H3,(H,22,24,26);1,4-7,12,14H,8-11H2,2H3,(H,21,24);3,6,9-11,15H,4-5,7-8H2,1-2H3,(H,21,23,27);3-4,7,10-11H,5-6,8-9H2,1-2H3,(H,18,22)
InChIKeyHLUPHYGKTNKBNT-UHFFFAOYSA-N
XLogP23.41
TPSA778.65 Ų
H-Bond Donors8
H-Bond Acceptors48
Rotatable Bonds35
Heavy Atoms232
Complexity—

Lipinski Rule of Five

4 violations

RuleValue
MW ≤ 5003454.84
LogP ≤ 523.41
H-Bond Donors ≤ 58
H-Bond Acceptors ≤ 1048

Computed Properties (RDKit)

Structural Alerts{'alert_name': 'triple_bond', 'substructure': 'N/A'}

Analyze 4-[1-[3-(1,1-difluoroethyl)-1-methylpyrazol-5-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3,5-difluorophenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide with MolForge

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Related Compounds

4-[2-[4-(1,1-difluoroethyl)phenyl]sulfonylpropan-2-yl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[2-(2,5-dimethylpyrazol-3-yl)sulfonylpropan-2-yl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[2-(2,5-dimethylpyrazol-3-yl)sulfonylpropan-2-yl]-N-pyridin-4-ylpiperidine-1-carboxamide;4-[2-(2,5-dimethylpyrazol-3-yl)sulfonylpropan-2-yl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[2-(4-ethynylphenyl)sulfonylpropan-2-yl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[2-(1-methylpyrrol-2-yl)sulfonylpropan-2-yl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-(2-pyrazolo[1,5-a]pyridin-5-ylsulfonylpropan-2-yl)-N-pyridazin-4-ylpiperidine-1-carboxamide;4-(2-pyrazolo[1,5-a]pyridin-6-ylsulfonylpropan-2-yl)-N-pyridazin-4-ylpiperidine-1-carboxamide
CID 157132252
bis(1-(4-fluorophenyl)-N-[(1S)-1-(2-methylsulfonyl-4-pyridinyl)butyl]-5-(trifluoromethyl)-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide);1-(4-fluorophenyl)-N-[(1S)-1-(2-methylsulfonyl-4-pyridinyl)propyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-(4-fluorophenyl)-N-[(1S)-1-(2-methylsulfonyl-4-pyridinyl)propyl]-5-(trifluoromethyl)-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide
CID 157455361
N-[(1S)-1-(4-bromo-2-fluorophenyl)butyl]-1-(4-fluorophenyl)-5-(trifluoromethyl)-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-cyclohexyl-N-[(1S)-1-(2-methylsulfonyl-4-pyridinyl)butyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-cyclohexyl-N-[(1S)-1-(2-methylsulfonyl-4-pyridinyl)propyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-cyclopentyl-N-[(1S)-1-(2-methylsulfonyl-4-pyridinyl)butyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;N-[(1S)-1-(2-fluoro-4-methylsulfonylphenyl)butyl]-1-(4-fluorophenyl)-5-(trifluoromethyl)-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide
CID 158143374
4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonylcyclobutyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonylcyclobutyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[2-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonylpropan-2-yl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[3,3-difluoro-2-(3-methylphenyl)sulfonylbutan-2-yl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-fluoro-5-methylphenyl)sulfonylcyclobutyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[2-(3-fluoro-5-methylphenyl)sulfonylpropan-2-yl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(1-methylpyrrol-2-yl)sulfonylcyclobutyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(1-methylpyrrol-2-yl)sulfonylcyclobutyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide
CID 158676375
1-(4-fluorophenyl)-N-[[4-(methylsulfamoyl)phenyl]methyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-(4-fluorophenyl)-N-[(3-methylsulfonylphenyl)methyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-(4-fluorophenyl)-N-[(4-methylsulfonylphenyl)methyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-(4-fluorophenyl)-N-[1-(5-methylsulfonyl-3-pyridinyl)butyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-(4-fluorophenyl)-N-[[3-(trifluoromethyl)phenyl]methyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide
CID 159472279
N-[(1S)-1-(2-fluoro-5-methylsulfonylphenyl)butyl]-1-(4-fluorophenyl)-5-(trifluoromethyl)-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-(4-fluorophenyl)-N-[(1S)-1-(5-methylsulfonyl-3-pyridinyl)butyl]-5,6,7,8-tetrahydropyrazolo[4,5-b]azepine-4-carboxamide;1-(4-fluorophenyl)-N-[(2-methylsulfonyl-4-pyridinyl)methyl]-5,6,7,8-tetrahydropyrazolo[4,5-b]azepine-4-carboxamide;1-(4-fluorophenyl)-N-[(2-methylsulfonyl-4-pyridinyl)methyl]-6-(trifluoromethyl)-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide
CID 159589905
4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(3-fluoro-5-methylphenyl)sulfonylethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-fluoro-1-(3-methylphenyl)sulfonylethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide
CID 159669525
4-[2-[4-(1,1-difluoroethyl)phenyl]sulfonylpropan-2-yl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[3,3-difluoro-2-(3-fluorophenyl)sulfonylbutan-2-yl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[2-(2,5-dimethylpyrazol-3-yl)sulfonylpropan-2-yl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[2-(2,5-dimethylpyrazol-3-yl)sulfonylpropan-2-yl]-N-pyridin-4-ylpiperidine-1-carboxamide;4-[2-(2,5-dimethylpyrazol-3-yl)sulfonylpropan-2-yl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[2-(4-ethynylphenyl)sulfonylpropan-2-yl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-(1-methylpyrrol-2-yl)sulfonylcyclobutyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-(2-pyrazolo[1,5-a]pyridin-6-ylsulfonylpropan-2-yl)-N-pyridazin-4-ylpiperidine-1-carboxamide
CID 160173962
4-[2-[4-(1,1-difluoroethyl)phenyl]sulfonylpropan-2-yl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[3,3-difluoro-2-(3-methylphenyl)sulfonylbutan-2-yl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[2-(2,5-dimethylpyrazol-3-yl)sulfonylpropan-2-yl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[2-(2,5-dimethylpyrazol-3-yl)sulfonylpropan-2-yl]-N-pyridin-4-ylpiperidine-1-carboxamide;4-[2-(2,5-dimethylpyrazol-3-yl)sulfonylpropan-2-yl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[2-(4-ethynylphenyl)sulfonylpropan-2-yl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-(1-methylpyrrol-2-yl)sulfonylcyclobutyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(1-methylpyrrol-2-yl)sulfonylcyclobutyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide
CID 160285426
1-(2,4-difluorophenyl)-N-[(1S)-1-(2-methylsulfonyl-4-pyridinyl)butyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-(4-fluorophenyl)-N-[(1S)-1-(2-methylsulfonyl-4-pyridinyl)butyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-(4-fluorophenyl)-N-[(1S)-1-(5-methylsulfonyl-3-pyridinyl)butyl]-5-(trifluoromethyl)-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-(4-fluorophenyl)-N-[1-(2-methylsulfonyl-4-pyridinyl)cyclopropyl]-5-(trifluoromethyl)-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;N-[(1S)-1-(2-methylsulfonyl-4-pyridinyl)butyl]-1-(2,4,6-trifluorophenyl)-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide
CID 160415473
1-(4-fluorophenyl)-N-[[4-(2-methoxyethylsulfamoyl)phenyl]methyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-(4-fluorophenyl)-N-[[3-(methylsulfamoyl)phenyl]methyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-(4-fluorophenyl)-N-[(6-methylsulfonyl-3-pyridinyl)methyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-(4-fluorophenyl)-N-[(4-morpholin-4-ylsulfonylphenyl)methyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-(4-fluorophenyl)-N-[[4-(oxan-4-ylsulfamoyl)phenyl]methyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide
CID 159263568
1-(4-fluorophenyl)-5-methyl-N-[(1S)-1-(2-methylsulfonyl-4-pyridinyl)ethyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-(4-fluorophenyl)-5-methyl-N-[(2-methylsulfonyl-4-pyridinyl)methyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-(4-fluorophenyl)-5-methyl-N-[(1S)-1-(2-methylsulfonyl-4-pyridinyl)propyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-(4-fluorophenyl)-N-[(1S)-1-(6-methylsulfonyl-3-pyridinyl)ethyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide;1-(4-fluorophenyl)-N-[(1S)-1-(6-methylsulfonyl-3-pyridinyl)propyl]-6,7-dihydro-5H-pyrazolo[4,5-b]pyridine-4-carboxamide
CID 160086971

Frequently Asked Questions

What is the IUPAC name of 4-[1-[3-(1,1-difluoroethyl)-1-methylpyrazol-5-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3,5-difluorophenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide?
The IUPAC name of 4-[1-[3-(1,1-difluoroethyl)-1-methylpyrazol-5-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3,5-difluorophenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide (CID 158517483) is 4-[1-[3-(1,1-difluoroethyl)-1-methylpyrazol-5-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3,5-difluorophenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide.
What is the SMILES notation for 4-[1-[3-(1,1-difluoroethyl)-1-methylpyrazol-5-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3,5-difluorophenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide?
The canonical SMILES for 4-[1-[3-(1,1-difluoroethyl)-1-methylpyrazol-5-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3,5-difluorophenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide is C#Cc1ccc(S(=O)(=O)C(C)(F)C2CCN(C(=O)Nc3ccnnc3)CC2)cc1.C#Cc1ccc(S(=O)(=O)C(C)(F)C2CCN(C(=O)Nc3cnns3)CC2)cc1.C#Cc1cccc(S(=O)(=O)C(C)(F)C2CCN(C(=O)Nc3ccnnc3)CC2)c1.CC(F)(C1CCN(C(=O)Nc2ccnnc2)CC1)S(=O)(=O)c1cc(F)cc(F)c1.CC(F)(F)c1ccc(S(=O)(=O)C(C)(F)C2CCN(C(=O)Nc3cnns3)CC2)cc1.Cn1cc(S(=O)(=O)C(C)(F)C2CCN(C(=O)Nc3ccnnc3)CC2)c(C(F)F)n1.Cn1cccc1S(=O)(=O)C(C)(F)C1CCN(C(=O)Nc2cnns2)CC1.Cn1nc(C(C)(F)F)cc1S(=O)(=O)C(C)(F)C1CCN(C(=O)Nc2ccnnc2)CC1.
What is the InChIKey of 4-[1-[3-(1,1-difluoroethyl)-1-methylpyrazol-5-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3,5-difluorophenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide?
The InChIKey is HLUPHYGKTNKBNT-UHFFFAOYSA-N. The full InChI is InChI=1S/2C20H21FN4O3S.C18H23F3N6O3S.C18H21F3N4O3S2.C18H19F3N4O3S.C18H19FN4O3S2.C17H21F3N6O3S.C15H20FN5O3S2/c1-3-15-4-6-18(7-5-15)29(27,28)20(2,21)16-9-12-25(13-10-16)19(26)24-17-8-11-22-23-14-17;1-3-15-5-4-6-18(13-15)29(27,28)20(2,21)16-8-11-25(12-9-16)19(26)24-17-7-10-22-23-14-17;1-17(19,20)14-10-15(26(3)25-14)31(29,30)18(2,21)12-5-8-27(9-6-12)16(28)24-13-4-7-22-23-11-13;1-17(19,20)12-3-5-14(6-4-12)30(27,28)18(2,21)13-7-9-25(10-8-13)16(26)23-15-11-22-24-29-15;1-18(21,29(27,28)16-9-13(19)8-14(20)10-16)12-3-6-25(7-4-12)17(26)24-15-2-5-22-23-11-15;1-3-13-4-6-15(7-5-13)28(25,26)18(2,19)14-8-10-23(11-9-14)17(24)21-16-12-20-22-27-16;1-17(20,30(28,29)13-10-25(2)24-14(13)15(18)19)11-4-7-26(8-5-11)16(27)23-12-3-6-21-22-9-12;1-15(16,26(23,24)13-4-3-7-20(13)2)11-5-8-21(9-6-11)14(22)18-12-10-17-19-25-12/h1,4-8,11,14,16H,9-10,12-13H2,2H3,(H,22,24,26);1,4-7,10,13-14,16H,8-9,11-12H2,2H3,(H,22,24,26);4,7,10-12H,5-6,8-9H2,1-3H3,(H,22,24,28);3-6,11,13H,7-10H2,1-2H3,(H,23,26);2,5,8-12H,3-4,6-7H2,1H3,(H,22,24,26);1,4-7,12,14H,8-11H2,2H3,(H,21,24);3,6,9-11,15H,4-5,7-8H2,1-2H3,(H,21,23,27);3-4,7,10-11H,5-6,8-9H2,1-2H3,(H,18,22).
What are the key properties of 4-[1-[3-(1,1-difluoroethyl)-1-methylpyrazol-5-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3,5-difluorophenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide?
4-[1-[3-(1,1-difluoroethyl)-1-methylpyrazol-5-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3,5-difluorophenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide has a molecular weight of 3454.84 g/mol, XLogP of 23.41, 35 rotatable bonds, 8 hydrogen bond donors, and 48 hydrogen bond acceptors.
Where does this data come from?
All data for 4-[1-[3-(1,1-difluoroethyl)-1-methylpyrazol-5-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-[4-(1,1-difluoroethyl)phenyl]sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-[3-(difluoromethyl)-1-methylpyrazol-4-yl]sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3,5-difluorophenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(3-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-pyridazin-4-ylpiperidine-1-carboxamide;4-[1-(4-ethynylphenyl)sulfonyl-1-fluoroethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide;4-[1-fluoro-1-(1-methylpyrrol-2-yl)sulfonylethyl]-N-(thiadiazol-5-yl)piperidine-1-carboxamide is sourced from PubChem (CID 158517483), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).