cyclopropyl-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;(2,2-difluorocyclopropyl)-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;[(2R,6S)-2,6-dimethyl-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]-(1-propan-2-ylpyrazol-3-yl)methanone;6-phenoxy-3-[4-[(3S)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine;6-phenoxy-3-[4-[(3R)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine

C121H113F11N38O5 — CID 158554525

About cyclopropyl-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;(2,2-difluorocyclopropyl)-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;[(2R,6S)-2,6-dimethyl-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]-(1-propan-2-ylpyrazol-3-yl)methanone;6-phenoxy-3-[4-[(3S)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine;6-phenoxy-3-[4-[(3R)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine

cyclopropyl-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;(2,2-difluorocyclopropyl)-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;[(2R,6S)-2,6-dimethyl-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]-(1-propan-2-ylpyrazol-3-yl)methanone;6-phenoxy-3-[4-[(3S)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine;6-phenoxy-3-[4-[(3R)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine (PubChem CID 158554525) has the molecular formula C121H113F11N38O5 and a molecular weight of 2388.47 g/mol. Its IUPAC name is cyclopropyl-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;(2,2-difluorocyclopropyl)-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;[(2R,6S)-2,6-dimethyl-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]-(1-propan-2-ylpyrazol-3-yl)methanone;6-phenoxy-3-[4-[(3S)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine;6-phenoxy-3-[4-[(3R)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine.

Molecular Properties

• Compound Name: cyclopropyl-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;(2,2-difluorocyclopropyl)-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;[(2R,6S)-2,6-dimethyl-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]-(1-propan-2-ylpyrazol-3-yl)methanone;6-phenoxy-3-[4-[(3S)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine;6-phenoxy-3-[4-[(3R)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine
• PubChem CID: 158554525
• Molecular Formula: C121H113F11N38O5
• Molecular Weight: 2388.47 g/mol
• Exact Mass: 2386.96
• IUPAC Name: cyclopropyl-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;(2,2-difluorocyclopropyl)-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;[(2R,6S)-2,6-dimethyl-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]-(1-propan-2-ylpyrazol-3-yl)methanone;6-phenoxy-3-[4-[(3S)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine;6-phenoxy-3-[4-[(3R)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine
• SMILES: CC(C)n1ccc(C(=O)N2[C@H](C)CN(c3ccnc(-c4cnc5ccc(C(F)(F)F)cn45)n3)C[C@@H]2C)n1.O=C(C1CC1(F)F)N1CCN(c2ccnc(-c3cnc4ccc(C(F)(F)F)cn34)n2)CC1c1cn[nH]c1.O=C(C1CC1)N1CCN(c2ccnc(-c3cnc4ccc(C(F)(F)F)cn34)n2)CC1c1cn[nH]c1.c1ccc(Oc2ccc3ncc(-c4nccc(N5CCC[C@@H](c6cn[nH]c6)C5)n4)n3c2)cc1.c1ccc(Oc2ccc3ncc(-c4nccc(N5CCC[C@H](c6cn[nH]c6)C5)n4)n3c2)cc1
• InChI: InChI=1S/C25H27F3N8O.2C25H23N7O.C23H19F5N8O.C23H21F3N8O/c1-15(2)35-10-8-19(32-35)24(37)36-16(3)12-33(13-17(36)4)22-7-9-29-23(31-22)20-11-30-21-6-5-18(14-34(20)21)25(26,27)28;2*1-2-6-20(7-3-1)33-21-8-9-23-27-15-22(32(23)17-21)25-26-11-10-24(30-25)31-12-4-5-18(16-31)19-13-28-29-14-19;24-22(25)7-15(22)21(37)35-6-5-34(12-17(35)13-8-31-32-9-13)19-3-4-29-20(33-19)16-10-30-18-2-1-14(11-36(16)18)23(26,27)28;24-23(25,26)16-3-4-19-28-11-17(34(19)12-16)21-27-6-5-20(31-21)32-7-8-33(22(35)14-1-2-14)18(13-32)15-9-29-30-10-15/h5-11,14-17H,12-13H2,1-4H3;2*1-3,6-11,13-15,17-18H,4-5,12,16H2,(H,28,29);1-4,8-11,15,17H,5-7,12H2,(H,31,32);3-6,9-12,14,18H,1-2,7-8,13H2,(H,29,30)/t16-,17+;2*18-;;/m.10../s1
• InChIKey: HQCVEPURDVIUBO-KFEQVTKUSA-N
• XLogP: 20.62
• TPSA: 443.53 Ų
• H-Bond Donors: 4
• H-Bond Acceptors: 36
• Rotatable Bonds: 22
• Heavy Atoms: 175
• Complexity: —

Lipinski Rule of Five

3 violations

Rule	Value
MW ≤ 500	2388.47
LogP ≤ 5	20.62
H-Bond Donors ≤ 5	4
H-Bond Acceptors ≤ 10	36

Frequently Asked Questions

What is the IUPAC name of cyclopropyl-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;(2,2-difluorocyclopropyl)-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;[(2R,6S)-2,6-dimethyl-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]-(1-propan-2-ylpyrazol-3-yl)methanone;6-phenoxy-3-[4-[(3S)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine;6-phenoxy-3-[4-[(3R)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine?

The IUPAC name of cyclopropyl-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;(2,2-difluorocyclopropyl)-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;[(2R,6S)-2,6-dimethyl-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]-(1-propan-2-ylpyrazol-3-yl)methanone;6-phenoxy-3-[4-[(3S)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine;6-phenoxy-3-[4-[(3R)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine (CID 158554525) is cyclopropyl-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;(2,2-difluorocyclopropyl)-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;[(2R,6S)-2,6-dimethyl-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]-(1-propan-2-ylpyrazol-3-yl)methanone;6-phenoxy-3-[4-[(3S)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine;6-phenoxy-3-[4-[(3R)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine.

What is the SMILES notation for cyclopropyl-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;(2,2-difluorocyclopropyl)-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;[(2R,6S)-2,6-dimethyl-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]-(1-propan-2-ylpyrazol-3-yl)methanone;6-phenoxy-3-[4-[(3S)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine;6-phenoxy-3-[4-[(3R)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine?

The canonical SMILES for cyclopropyl-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;(2,2-difluorocyclopropyl)-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;[(2R,6S)-2,6-dimethyl-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]-(1-propan-2-ylpyrazol-3-yl)methanone;6-phenoxy-3-[4-[(3S)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine;6-phenoxy-3-[4-[(3R)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine is CC(C)n1ccc(C(=O)N2[C@H](C)CN(c3ccnc(-c4cnc5ccc(C(F)(F)F)cn45)n3)C[C@@H]2C)n1.O=C(C1CC1(F)F)N1CCN(c2ccnc(-c3cnc4ccc(C(F)(F)F)cn34)n2)CC1c1cn[nH]c1.O=C(C1CC1)N1CCN(c2ccnc(-c3cnc4ccc(C(F)(F)F)cn34)n2)CC1c1cn[nH]c1.c1ccc(Oc2ccc3ncc(-c4nccc(N5CCC[C@@H](c6cn[nH]c6)C5)n4)n3c2)cc1.c1ccc(Oc2ccc3ncc(-c4nccc(N5CCC[C@H](c6cn[nH]c6)C5)n4)n3c2)cc1.

What is the InChIKey of cyclopropyl-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;(2,2-difluorocyclopropyl)-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;[(2R,6S)-2,6-dimethyl-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]-(1-propan-2-ylpyrazol-3-yl)methanone;6-phenoxy-3-[4-[(3S)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine;6-phenoxy-3-[4-[(3R)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine?

The InChIKey is HQCVEPURDVIUBO-KFEQVTKUSA-N. The full InChI is InChI=1S/C25H27F3N8O.2C25H23N7O.C23H19F5N8O.C23H21F3N8O/c1-15(2)35-10-8-19(32-35)24(37)36-16(3)12-33(13-17(36)4)22-7-9-29-23(31-22)20-11-30-21-6-5-18(14-34(20)21)25(26,27)28;2*1-2-6-20(7-3-1)33-21-8-9-23-27-15-22(32(23)17-21)25-26-11-10-24(30-25)31-12-4-5-18(16-31)19-13-28-29-14-19;24-22(25)7-15(22)21(37)35-6-5-34(12-17(35)13-8-31-32-9-13)19-3-4-29-20(33-19)16-10-30-18-2-1-14(11-36(16)18)23(26,27)28;24-23(25,26)16-3-4-19-28-11-17(34(19)12-16)21-27-6-5-20(31-21)32-7-8-33(22(35)14-1-2-14)18(13-32)15-9-29-30-10-15/h5-11,14-17H,12-13H2,1-4H3;2*1-3,6-11,13-15,17-18H,4-5,12,16H2,(H,28,29);1-4,8-11,15,17H,5-7,12H2,(H,31,32);3-6,9-12,14,18H,1-2,7-8,13H2,(H,29,30)/t16-,17+;2*18-;;/m.10../s1.

What are the key properties of cyclopropyl-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;(2,2-difluorocyclopropyl)-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;[(2R,6S)-2,6-dimethyl-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]-(1-propan-2-ylpyrazol-3-yl)methanone;6-phenoxy-3-[4-[(3S)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine;6-phenoxy-3-[4-[(3R)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine?

cyclopropyl-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;(2,2-difluorocyclopropyl)-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;[(2R,6S)-2,6-dimethyl-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]-(1-propan-2-ylpyrazol-3-yl)methanone;6-phenoxy-3-[4-[(3S)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine;6-phenoxy-3-[4-[(3R)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine has a molecular weight of 2388.47 g/mol, XLogP of 20.62, 22 rotatable bonds, 4 hydrogen bond donors, and 36 hydrogen bond acceptors.

Where does this data come from?

All data for cyclopropyl-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;(2,2-difluorocyclopropyl)-[2-(1H-pyrazol-4-yl)-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]methanone;[(2R,6S)-2,6-dimethyl-4-[2-[6-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-yl]piperazin-1-yl]-(1-propan-2-ylpyrazol-3-yl)methanone;6-phenoxy-3-[4-[(3S)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine;6-phenoxy-3-[4-[(3R)-3-(1H-pyrazol-4-yl)piperidin-1-yl]pyrimidin-2-yl]imidazo[1,2-a]pyridine is sourced from PubChem (CID 158554525), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).