2-(cyclopentylmethoxy)-7-(8-methylnaphthalen-1-yl)-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-(3,3-dimethyl-4-prop-2-enoylpiperazin-1-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(E)-4,4,4-trifluorobut-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(Z)-3-(1-methylpyrrolidin-2-yl)prop-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2,5-diazabicyclo[4.1.0]heptan-2-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1S,5R)-3-prop-2-enoyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile

C274H315F3N50O17 — CID 158834288

IUPAC2-(cyclopentylmethoxy)-7-(8-methylnaphthalen-1-yl)-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-(3,3-dimethyl-4-prop-2-enoylpiperazin-1-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(E)-4,4,4-trifluorobut-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(Z)-3-(1-methylpyrrolidin-2-yl)prop-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2,5-diazabicyclo[4.1.0]heptan-2-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1S,5R)-3-prop-2-enoyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile
SMILESC=CC(=O)N1CC(Nc2c(C#N)c(OC[C@H]3CCCN3C)nc3c2CCN(c2cccc4cccc(C)c24)C3)C1.C=CC(=O)N1CC2(C1)CN(c1c(C#N)c(OCC3CCCC3)nc3c1CCN(c1cccc4cccc(C)c14)C3)C2.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cccc(C)c24)C3)C2CC21.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cccc(C)c24)C3)CC1(C)C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cccc(C)c24)C3)CC12COC2.C=CC(=O)N1C[C@H]2CC[C@@H](C1)N2c1c(C#N)c(OC[C@@H]2CCCN2C)nc2c1CCN(c1cccc3cccc(C)c13)C2.Cc1ccc2[nH]ncc2c1N1CCc2c(nc(OC[C@@H]3CCCN3C)c(C#N)c2N2CCN(C(=O)/C=C/C(F)(F)F)CC2)C1.Cc1cccc2cccc(N3CCc4c(nc(OC[C@@H]5CCCN5C)c(C#N)c4N4CCN(C(=O)/C=C\C5CCCN5C)CC4)C3)c12
InChIInChI=1S/C38H47N7O2.C35H40N6O3.C35H40N6O2.C35H42N6O2.C34H38N6O2.C34H37N5O2.C32H36N6O2.C31H35F3N8O2/c1-27-8-4-9-28-10-5-13-34(36(27)28)45-19-16-31-33(25-45)40-38(47-26-30-12-7-18-42(30)3)32(24-39)37(31)44-22-20-43(21-23-44)35(46)15-14-29-11-6-17-41(29)2;1-4-31(42)41-17-16-40(21-35(41)22-43-23-35)33-27-13-15-39(30-12-6-10-25-9-5-8-24(2)32(25)30)19-29(27)37-34(28(33)18-36)44-20-26-11-7-14-38(26)3;1-4-32(42)40-19-25-13-14-26(20-40)41(25)34-28-15-17-39(31-12-6-10-24-9-5-8-23(2)33(24)31)21-30(28)37-35(29(34)18-36)43-22-27-11-7-16-38(27)3;1-6-31(42)41-19-18-40(23-35(41,3)4)33-27-15-17-39(30-14-8-12-25-11-7-10-24(2)32(25)30)21-29(27)37-34(28(33)20-36)43-22-26-13-9-16-38(26)5;1-4-31(41)39-16-17-40(30-18-29(30)39)33-25-13-15-38(28-12-6-10-23-9-5-8-22(2)32(23)28)20-27(25)36-34(26(33)19-35)42-21-24-11-7-14-37(24)3;1-3-30(40)38-19-34(20-38)21-39(22-34)32-26-14-15-37(29-13-7-12-25-11-6-8-23(2)31(25)29)17-28(26)36-33(27(32)16-35)41-18-24-9-4-5-10-24;1-4-29(39)38-17-23(18-38)34-31-25-13-15-37(28-12-6-10-22-9-5-8-21(2)30(22)28)19-27(25)35-32(26(31)16-33)40-20-24-11-7-14-36(24)3;1-20-5-6-25-24(17-36-38-25)28(20)42-11-8-22-26(18-42)37-30(44-19-21-4-3-10-39(21)2)23(16-35)29(22)41-14-12-40(13-15-41)27(43)7-9-31(32,33)34/h4-5,8-10,13-15,29-30H,6-7,11-12,16-23,25-26H2,1-3H3;4-6,8-10,12,26H,1,7,11,13-17,19-23H2,2-3H3;4-6,8-10,12,25-27H,1,7,11,13-17,19-22H2,2-3H3;6-8,10-12,14,26H,1,9,13,15-19,21-23H2,2-5H3;4-6,8-10,12,24,29-30H,1,7,11,13-18,20-21H2,2-3H3;3,6-8,11-13,24H,1,4-5,9-10,14-15,17-22H2,2H3;4-6,8-10,12,23-24H,1,7,11,13-15,17-20H2,2-3H3,(H,34,35);5-7,9,17,21H,3-4,8,10-15,18-19H2,1-2H3,(H,36,38)/b15-14-;;;;;;;9-7+/t29?,30-;26-;25-,26+,27-;26-;24-,29?,30?;;24-;21-/m00000.10/s1
InChIKeyIXKYRWKVNBNUSP-JQVNEGELSA-N
MW4637.86 g/mol
LogP36.69
Rot. Bonds50

About 2-(cyclopentylmethoxy)-7-(8-methylnaphthalen-1-yl)-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-(3,3-dimethyl-4-prop-2-enoylpiperazin-1-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(E)-4,4,4-trifluorobut-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(Z)-3-(1-methylpyrrolidin-2-yl)prop-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2,5-diazabicyclo[4.1.0]heptan-2-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1S,5R)-3-prop-2-enoyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile

2-(cyclopentylmethoxy)-7-(8-methylnaphthalen-1-yl)-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-(3,3-dimethyl-4-prop-2-enoylpiperazin-1-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(E)-4,4,4-trifluorobut-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(Z)-3-(1-methylpyrrolidin-2-yl)prop-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2,5-diazabicyclo[4.1.0]heptan-2-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1S,5R)-3-prop-2-enoyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile (PubChem CID 158834288) has the molecular formula C274H315F3N50O17 and a molecular weight of 4637.86 g/mol. Its IUPAC name is 2-(cyclopentylmethoxy)-7-(8-methylnaphthalen-1-yl)-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-(3,3-dimethyl-4-prop-2-enoylpiperazin-1-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(E)-4,4,4-trifluorobut-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(Z)-3-(1-methylpyrrolidin-2-yl)prop-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2,5-diazabicyclo[4.1.0]heptan-2-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1S,5R)-3-prop-2-enoyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile.

Molecular Properties

Compound Name2-(cyclopentylmethoxy)-7-(8-methylnaphthalen-1-yl)-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-(3,3-dimethyl-4-prop-2-enoylpiperazin-1-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(E)-4,4,4-trifluorobut-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(Z)-3-(1-methylpyrrolidin-2-yl)prop-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2,5-diazabicyclo[4.1.0]heptan-2-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1S,5R)-3-prop-2-enoyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile
PubChem CID158834288
Molecular FormulaC274H315F3N50O17
Molecular Weight4637.86 g/mol
Exact Mass4634.53
IUPAC Name2-(cyclopentylmethoxy)-7-(8-methylnaphthalen-1-yl)-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-(3,3-dimethyl-4-prop-2-enoylpiperazin-1-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(E)-4,4,4-trifluorobut-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(Z)-3-(1-methylpyrrolidin-2-yl)prop-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2,5-diazabicyclo[4.1.0]heptan-2-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1S,5R)-3-prop-2-enoyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile
SMILESC=CC(=O)N1CC(Nc2c(C#N)c(OC[C@H]3CCCN3C)nc3c2CCN(c2cccc4cccc(C)c24)C3)C1.C=CC(=O)N1CC2(C1)CN(c1c(C#N)c(OCC3CCCC3)nc3c1CCN(c1cccc4cccc(C)c14)C3)C2.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cccc(C)c24)C3)C2CC21.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cccc(C)c24)C3)CC1(C)C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cccc(C)c24)C3)CC12COC2.C=CC(=O)N1C[C@H]2CC[C@@H](C1)N2c1c(C#N)c(OC[C@@H]2CCCN2C)nc2c1CCN(c1cccc3cccc(C)c13)C2.Cc1ccc2[nH]ncc2c1N1CCc2c(nc(OC[C@@H]3CCCN3C)c(C#N)c2N2CCN(C(=O)/C=C/C(F)(F)F)CC2)C1.Cc1cccc2cccc(N3CCc4c(nc(OC[C@@H]5CCCN5C)c(C#N)c4N4CCN(C(=O)/C=C\C5CCCN5C)CC4)C3)c12
InChIInChI=1S/C38H47N7O2.C35H40N6O3.C35H40N6O2.C35H42N6O2.C34H38N6O2.C34H37N5O2.C32H36N6O2.C31H35F3N8O2/c1-27-8-4-9-28-10-5-13-34(36(27)28)45-19-16-31-33(25-45)40-38(47-26-30-12-7-18-42(30)3)32(24-39)37(31)44-22-20-43(21-23-44)35(46)15-14-29-11-6-17-41(29)2;1-4-31(42)41-17-16-40(21-35(41)22-43-23-35)33-27-13-15-39(30-12-6-10-25-9-5-8-24(2)32(25)30)19-29(27)37-34(28(33)18-36)44-20-26-11-7-14-38(26)3;1-4-32(42)40-19-25-13-14-26(20-40)41(25)34-28-15-17-39(31-12-6-10-24-9-5-8-23(2)33(24)31)21-30(28)37-35(29(34)18-36)43-22-27-11-7-16-38(27)3;1-6-31(42)41-19-18-40(23-35(41,3)4)33-27-15-17-39(30-14-8-12-25-11-7-10-24(2)32(25)30)21-29(27)37-34(28(33)20-36)43-22-26-13-9-16-38(26)5;1-4-31(41)39-16-17-40(30-18-29(30)39)33-25-13-15-38(28-12-6-10-23-9-5-8-22(2)32(23)28)20-27(25)36-34(26(33)19-35)42-21-24-11-7-14-37(24)3;1-3-30(40)38-19-34(20-38)21-39(22-34)32-26-14-15-37(29-13-7-12-25-11-6-8-23(2)31(25)29)17-28(26)36-33(27(32)16-35)41-18-24-9-4-5-10-24;1-4-29(39)38-17-23(18-38)34-31-25-13-15-37(28-12-6-10-22-9-5-8-21(2)30(22)28)19-27(25)35-32(26(31)16-33)40-20-24-11-7-14-36(24)3;1-20-5-6-25-24(17-36-38-25)28(20)42-11-8-22-26(18-42)37-30(44-19-21-4-3-10-39(21)2)23(16-35)29(22)41-14-12-40(13-15-41)27(43)7-9-31(32,33)34/h4-5,8-10,13-15,29-30H,6-7,11-12,16-23,25-26H2,1-3H3;4-6,8-10,12,26H,1,7,11,13-17,19-23H2,2-3H3;4-6,8-10,12,25-27H,1,7,11,13-17,19-22H2,2-3H3;6-8,10-12,14,26H,1,9,13,15-19,21-23H2,2-5H3;4-6,8-10,12,24,29-30H,1,7,11,13-18,20-21H2,2-3H3;3,6-8,11-13,24H,1,4-5,9-10,14-15,17-22H2,2H3;4-6,8-10,12,23-24H,1,7,11,13-15,17-20H2,2-3H3,(H,34,35);5-7,9,17,21H,3-4,8,10-15,18-19H2,1-2H3,(H,36,38)/b15-14-;;;;;;;9-7+/t29?,30-;26-;25-,26+,27-;26-;24-,29?,30?;;24-;21-/m00000.10/s1
InChIKeyIXKYRWKVNBNUSP-JQVNEGELSA-N
XLogP36.69
TPSA654.22 Ų
H-Bond Donors2
H-Bond Acceptors58
Rotatable Bonds50
Heavy Atoms344
Complexity—

Lipinski Rule of Five

3 violations

RuleValue
MW ≤ 5004637.86
LogP ≤ 536.69
H-Bond Donors ≤ 52
H-Bond Acceptors ≤ 1058

Analyze 2-(cyclopentylmethoxy)-7-(8-methylnaphthalen-1-yl)-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-(3,3-dimethyl-4-prop-2-enoylpiperazin-1-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(E)-4,4,4-trifluorobut-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(Z)-3-(1-methylpyrrolidin-2-yl)prop-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2,5-diazabicyclo[4.1.0]heptan-2-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1S,5R)-3-prop-2-enoyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile with MolForge

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Frequently Asked Questions

What is the IUPAC name of 2-(cyclopentylmethoxy)-7-(8-methylnaphthalen-1-yl)-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-(3,3-dimethyl-4-prop-2-enoylpiperazin-1-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(E)-4,4,4-trifluorobut-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(Z)-3-(1-methylpyrrolidin-2-yl)prop-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2,5-diazabicyclo[4.1.0]heptan-2-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1S,5R)-3-prop-2-enoyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile?
The IUPAC name of 2-(cyclopentylmethoxy)-7-(8-methylnaphthalen-1-yl)-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-(3,3-dimethyl-4-prop-2-enoylpiperazin-1-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(E)-4,4,4-trifluorobut-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(Z)-3-(1-methylpyrrolidin-2-yl)prop-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2,5-diazabicyclo[4.1.0]heptan-2-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1S,5R)-3-prop-2-enoyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile (CID 158834288) is 2-(cyclopentylmethoxy)-7-(8-methylnaphthalen-1-yl)-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-(3,3-dimethyl-4-prop-2-enoylpiperazin-1-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(E)-4,4,4-trifluorobut-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(Z)-3-(1-methylpyrrolidin-2-yl)prop-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2,5-diazabicyclo[4.1.0]heptan-2-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1S,5R)-3-prop-2-enoyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile.
What is the SMILES notation for 2-(cyclopentylmethoxy)-7-(8-methylnaphthalen-1-yl)-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-(3,3-dimethyl-4-prop-2-enoylpiperazin-1-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(E)-4,4,4-trifluorobut-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(Z)-3-(1-methylpyrrolidin-2-yl)prop-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2,5-diazabicyclo[4.1.0]heptan-2-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1S,5R)-3-prop-2-enoyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile?
The canonical SMILES for 2-(cyclopentylmethoxy)-7-(8-methylnaphthalen-1-yl)-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-(3,3-dimethyl-4-prop-2-enoylpiperazin-1-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(E)-4,4,4-trifluorobut-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(Z)-3-(1-methylpyrrolidin-2-yl)prop-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2,5-diazabicyclo[4.1.0]heptan-2-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1S,5R)-3-prop-2-enoyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile is C=CC(=O)N1CC(Nc2c(C#N)c(OC[C@H]3CCCN3C)nc3c2CCN(c2cccc4cccc(C)c24)C3)C1.C=CC(=O)N1CC2(C1)CN(c1c(C#N)c(OCC3CCCC3)nc3c1CCN(c1cccc4cccc(C)c14)C3)C2.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cccc(C)c24)C3)C2CC21.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cccc(C)c24)C3)CC1(C)C.C=CC(=O)N1CCN(c2c(C#N)c(OC[C@@H]3CCCN3C)nc3c2CCN(c2cccc4cccc(C)c24)C3)CC12COC2.C=CC(=O)N1C[C@H]2CC[C@@H](C1)N2c1c(C#N)c(OC[C@@H]2CCCN2C)nc2c1CCN(c1cccc3cccc(C)c13)C2.Cc1ccc2[nH]ncc2c1N1CCc2c(nc(OC[C@@H]3CCCN3C)c(C#N)c2N2CCN(C(=O)/C=C/C(F)(F)F)CC2)C1.Cc1cccc2cccc(N3CCc4c(nc(OC[C@@H]5CCCN5C)c(C#N)c4N4CCN(C(=O)/C=C\C5CCCN5C)CC4)C3)c12.
What is the InChIKey of 2-(cyclopentylmethoxy)-7-(8-methylnaphthalen-1-yl)-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-(3,3-dimethyl-4-prop-2-enoylpiperazin-1-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(E)-4,4,4-trifluorobut-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(Z)-3-(1-methylpyrrolidin-2-yl)prop-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2,5-diazabicyclo[4.1.0]heptan-2-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1S,5R)-3-prop-2-enoyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile?
The InChIKey is IXKYRWKVNBNUSP-JQVNEGELSA-N. The full InChI is InChI=1S/C38H47N7O2.C35H40N6O3.C35H40N6O2.C35H42N6O2.C34H38N6O2.C34H37N5O2.C32H36N6O2.C31H35F3N8O2/c1-27-8-4-9-28-10-5-13-34(36(27)28)45-19-16-31-33(25-45)40-38(47-26-30-12-7-18-42(30)3)32(24-39)37(31)44-22-20-43(21-23-44)35(46)15-14-29-11-6-17-41(29)2;1-4-31(42)41-17-16-40(21-35(41)22-43-23-35)33-27-13-15-39(30-12-6-10-25-9-5-8-24(2)32(25)30)19-29(27)37-34(28(33)18-36)44-20-26-11-7-14-38(26)3;1-4-32(42)40-19-25-13-14-26(20-40)41(25)34-28-15-17-39(31-12-6-10-24-9-5-8-23(2)33(24)31)21-30(28)37-35(29(34)18-36)43-22-27-11-7-16-38(27)3;1-6-31(42)41-19-18-40(23-35(41,3)4)33-27-15-17-39(30-14-8-12-25-11-7-10-24(2)32(25)30)21-29(27)37-34(28(33)20-36)43-22-26-13-9-16-38(26)5;1-4-31(41)39-16-17-40(30-18-29(30)39)33-25-13-15-38(28-12-6-10-23-9-5-8-22(2)32(23)28)20-27(25)36-34(26(33)19-35)42-21-24-11-7-14-37(24)3;1-3-30(40)38-19-34(20-38)21-39(22-34)32-26-14-15-37(29-13-7-12-25-11-6-8-23(2)31(25)29)17-28(26)36-33(27(32)16-35)41-18-24-9-4-5-10-24;1-4-29(39)38-17-23(18-38)34-31-25-13-15-37(28-12-6-10-22-9-5-8-21(2)30(22)28)19-27(25)35-32(26(31)16-33)40-20-24-11-7-14-36(24)3;1-20-5-6-25-24(17-36-38-25)28(20)42-11-8-22-26(18-42)37-30(44-19-21-4-3-10-39(21)2)23(16-35)29(22)41-14-12-40(13-15-41)27(43)7-9-31(32,33)34/h4-5,8-10,13-15,29-30H,6-7,11-12,16-23,25-26H2,1-3H3;4-6,8-10,12,26H,1,7,11,13-17,19-23H2,2-3H3;4-6,8-10,12,25-27H,1,7,11,13-17,19-22H2,2-3H3;6-8,10-12,14,26H,1,9,13,15-19,21-23H2,2-5H3;4-6,8-10,12,24,29-30H,1,7,11,13-18,20-21H2,2-3H3;3,6-8,11-13,24H,1,4-5,9-10,14-15,17-22H2,2H3;4-6,8-10,12,23-24H,1,7,11,13-15,17-20H2,2-3H3,(H,34,35);5-7,9,17,21H,3-4,8,10-15,18-19H2,1-2H3,(H,36,38)/b15-14-;;;;;;;9-7+/t29?,30-;26-;25-,26+,27-;26-;24-,29?,30?;;24-;21-/m00000.10/s1.
What are the key properties of 2-(cyclopentylmethoxy)-7-(8-methylnaphthalen-1-yl)-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-(3,3-dimethyl-4-prop-2-enoylpiperazin-1-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(E)-4,4,4-trifluorobut-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(Z)-3-(1-methylpyrrolidin-2-yl)prop-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2,5-diazabicyclo[4.1.0]heptan-2-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1S,5R)-3-prop-2-enoyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile?
2-(cyclopentylmethoxy)-7-(8-methylnaphthalen-1-yl)-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-(3,3-dimethyl-4-prop-2-enoylpiperazin-1-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(E)-4,4,4-trifluorobut-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(Z)-3-(1-methylpyrrolidin-2-yl)prop-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2,5-diazabicyclo[4.1.0]heptan-2-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1S,5R)-3-prop-2-enoyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile has a molecular weight of 4637.86 g/mol, XLogP of 36.69, 50 rotatable bonds, 2 hydrogen bond donors, and 58 hydrogen bond acceptors.
Where does this data come from?
All data for 2-(cyclopentylmethoxy)-7-(8-methylnaphthalen-1-yl)-4-(2-prop-2-enoyl-2,6-diazaspiro[3.3]heptan-6-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;4-(3,3-dimethyl-4-prop-2-enoylpiperazin-1-yl)-7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(5-methyl-1H-indazol-4-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(E)-4,4,4-trifluorobut-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[4-[(Z)-3-(1-methylpyrrolidin-2-yl)prop-2-enoyl]piperazin-1-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1-prop-2-enoylazetidin-3-yl)amino]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2,5-diazabicyclo[4.1.0]heptan-2-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-[(1S,5R)-3-prop-2-enoyl-3,8-diazabicyclo[3.2.1]octan-8-yl]-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile;7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-4-(5-prop-2-enoyl-2-oxa-5,8-diazaspiro[3.5]nonan-8-yl)-6,8-dihydro-5H-1,7-naphthyridine-3-carbonitrile is sourced from PubChem (CID 158834288), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).