N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(5,6-difluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(6-fluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;6-[2,5-dimethyl-4-(trifluoromethyl)imidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;6-(6-methoxy-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;N-[4-(2,2,2-trifluoroethoxy)phenyl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine

C95H67F24N25O4 — CID 159978681

IUPACN-[4-(difluoromethoxy)-3-fluorophenyl]-6-(5,6-difluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(6-fluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;6-[2,5-dimethyl-4-(trifluoromethyl)imidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;6-(6-methoxy-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;N-[4-(2,2,2-trifluoroethoxy)phenyl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine
SMILESCOc1ccc2nc(C)n(-c3cncc(Nc4ccc(C(F)(F)F)cc4)n3)c2c1.Cc1nc(C(F)(F)F)c(C)n1-c1cncc(Nc2ccc(C(F)(F)F)cc2)n1.Cc1nc2cc(F)c(F)cc2n1-c1cncc(Nc2ccc(OC(F)F)c(F)c2)n1.Cc1nc2ccc(F)cc2n1-c1cncc(Nc2ccc(OC(F)F)c(F)c2)n1.FC(F)(F)COc1ccc(Nc2cncc(-c3c(C(F)(F)F)nc4ccccn34)n2)cc1
InChIInChI=1S/C20H13F6N5O.C20H16F3N5O.C19H12F5N5O.C19H13F4N5O.C17H13F6N5/c21-19(22,23)11-32-13-6-4-12(5-7-13)28-15-10-27-9-14(29-15)17-18(20(24,25)26)30-16-3-1-2-8-31(16)17;1-12-25-16-8-7-15(29-2)9-17(16)28(12)19-11-24-10-18(27-19)26-14-5-3-13(4-6-14)20(21,22)23;1-9-26-14-5-11(20)12(21)6-15(14)29(9)18-8-25-7-17(28-18)27-10-2-3-16(13(22)4-10)30-19(23)24;1-10-25-14-4-2-11(20)6-15(14)28(10)18-9-24-8-17(27-18)26-12-3-5-16(13(21)7-12)29-19(22)23;1-9-15(17(21,22)23)25-10(2)28(9)14-8-24-7-13(27-14)26-12-5-3-11(4-6-12)16(18,19)20/h1-10H,11H2,(H,28,29);3-11H,1-2H3,(H,26,27);2-8,19H,1H3,(H,27,28);2-9,19H,1H3,(H,26,27);3-8H,1-2H3,(H,26,27)
InChIKeyOFMGXJZEXFDOAU-UHFFFAOYSA-N
MW2078.70 g/mol
LogP25.08
Rot. Bonds22

About N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(5,6-difluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(6-fluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;6-[2,5-dimethyl-4-(trifluoromethyl)imidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;6-(6-methoxy-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;N-[4-(2,2,2-trifluoroethoxy)phenyl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine

N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(5,6-difluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(6-fluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;6-[2,5-dimethyl-4-(trifluoromethyl)imidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;6-(6-methoxy-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;N-[4-(2,2,2-trifluoroethoxy)phenyl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine (PubChem CID 159978681) has the molecular formula C95H67F24N25O4 and a molecular weight of 2078.70 g/mol. Its IUPAC name is N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(5,6-difluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(6-fluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;6-[2,5-dimethyl-4-(trifluoromethyl)imidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;6-(6-methoxy-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;N-[4-(2,2,2-trifluoroethoxy)phenyl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine.

Molecular Properties

Compound NameN-[4-(difluoromethoxy)-3-fluorophenyl]-6-(5,6-difluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(6-fluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;6-[2,5-dimethyl-4-(trifluoromethyl)imidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;6-(6-methoxy-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;N-[4-(2,2,2-trifluoroethoxy)phenyl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine
PubChem CID159978681
Molecular FormulaC95H67F24N25O4
Molecular Weight2078.70 g/mol
Exact Mass2077.54
IUPAC NameN-[4-(difluoromethoxy)-3-fluorophenyl]-6-(5,6-difluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(6-fluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;6-[2,5-dimethyl-4-(trifluoromethyl)imidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;6-(6-methoxy-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;N-[4-(2,2,2-trifluoroethoxy)phenyl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine
SMILESCOc1ccc2nc(C)n(-c3cncc(Nc4ccc(C(F)(F)F)cc4)n3)c2c1.Cc1nc(C(F)(F)F)c(C)n1-c1cncc(Nc2ccc(C(F)(F)F)cc2)n1.Cc1nc2cc(F)c(F)cc2n1-c1cncc(Nc2ccc(OC(F)F)c(F)c2)n1.Cc1nc2ccc(F)cc2n1-c1cncc(Nc2ccc(OC(F)F)c(F)c2)n1.FC(F)(F)COc1ccc(Nc2cncc(-c3c(C(F)(F)F)nc4ccccn34)n2)cc1
InChIInChI=1S/C20H13F6N5O.C20H16F3N5O.C19H12F5N5O.C19H13F4N5O.C17H13F6N5/c21-19(22,23)11-32-13-6-4-12(5-7-13)28-15-10-27-9-14(29-15)17-18(20(24,25)26)30-16-3-1-2-8-31(16)17;1-12-25-16-8-7-15(29-2)9-17(16)28(12)19-11-24-10-18(27-19)26-14-5-3-13(4-6-14)20(21,22)23;1-9-26-14-5-11(20)12(21)6-15(14)29(9)18-8-25-7-17(28-18)27-10-2-3-16(13(22)4-10)30-19(23)24;1-10-25-14-4-2-11(20)6-15(14)28(10)18-9-24-8-17(27-18)26-12-3-5-16(13(21)7-12)29-19(22)23;1-9-15(17(21,22)23)25-10(2)28(9)14-8-24-7-13(27-14)26-12-5-3-11(4-6-12)16(18,19)20/h1-10H,11H2,(H,28,29);3-11H,1-2H3,(H,26,27);2-8,19H,1H3,(H,27,28);2-9,19H,1H3,(H,26,27);3-8H,1-2H3,(H,26,27)
InChIKeyOFMGXJZEXFDOAU-UHFFFAOYSA-N
XLogP25.08
TPSA314.55 Ų
H-Bond Donors5
H-Bond Acceptors29
Rotatable Bonds22
Heavy Atoms148
Complexity—

Lipinski Rule of Five

3 violations

RuleValue
MW ≤ 5002078.70
LogP ≤ 525.08
H-Bond Donors ≤ 55
H-Bond Acceptors ≤ 1029

Analyze N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(5,6-difluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(6-fluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;6-[2,5-dimethyl-4-(trifluoromethyl)imidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;6-(6-methoxy-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;N-[4-(2,2,2-trifluoroethoxy)phenyl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine with MolForge

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Related Compounds

1-methyl-6-[[2-[2-(trifluoromethyl)-1H-imidazol-5-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine
CID 57399335
1-methyl-5-[2-(1-methylbenzimidazol-2-yl)pyridin-4-yl]oxy-N-[3-(trifluoromethyl)phenyl]benzimidazol-2-amine
CID 21037102
1-methyl-N-(3-pyridin-4-ylphenyl)-5-[[2-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-4-pyridinyl]oxy]benzimidazol-2-amine
CID 22040365
bis[N-[1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]benzimidazol-2-yl]-4-(trifluoromethyl)anilino] (Z)-but-2-enedioate
CID 87260082
1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-(2,3,5-trifluoro-4-methylphenyl)benzimidazol-2-amine
CID 87536253
1-methyl-5-[[2-[1-methyl-5-(trifluoromethyl)imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine
CID 88440814
1-methyl-5-[[2-[1-methyl-4-(trifluoromethyl)imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]benzimidazol-2-amine
CID 90695710
6-(2-cyclopropylimidazo[1,2-a]pyridin-5-yl)-N-[4-(difluoromethoxy)phenyl]pyrazin-2-amine;6-(2-cyclopropylimidazo[1,2-a]pyridin-5-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine
CID 118094917
2-[3-(Fluoromethoxy)phenyl]-7-pyrrolidin-1-ylimidazo[1,2-a]pyrimidine;7-(4-fluoropiperidin-1-yl)-2-(4-pyrrolidin-1-ylphenyl)imidazo[1,2-a]pyrimidine;7-(4-fluoropiperidin-1-yl)-2-[3-(trifluoromethoxy)phenyl]imidazo[1,2-a]pyrimidine
CID 118975974
N-[3-(difluoromethyl)phenyl]-3-[[11-[3-(2-fluoroethoxy)-4-methylanilino]-4,8,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-8-yl]methyl]-8-methyl-4,8,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-amine
CID 123194403
N-(3-fluoro-4-methoxyphenyl)-3-[[11-[(5-fluoro-3-pyridinyl)amino]-3-[[11-[(6-fluoro-2-pyridinyl)amino]-4,8,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-8-yl]methyl]-4,8,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-8-yl]methyl]-8-methyl-4,8,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2(7),3,5,10,12-hexaen-11-amine
CID 123428579
4-[[8-[3-[4-[[8-(2,6-Difluoroanilino)-9-(oxan-4-yl)purin-2-yl]amino]-1-methylcyclohexyl]oxy-2,4-difluoroanilino]-9-(oxan-4-yl)purin-2-yl]amino]-1-methylcyclohexan-1-ol
CID 123627293

Frequently Asked Questions

What is the IUPAC name of N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(5,6-difluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(6-fluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;6-[2,5-dimethyl-4-(trifluoromethyl)imidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;6-(6-methoxy-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;N-[4-(2,2,2-trifluoroethoxy)phenyl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine?
The IUPAC name of N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(5,6-difluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(6-fluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;6-[2,5-dimethyl-4-(trifluoromethyl)imidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;6-(6-methoxy-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;N-[4-(2,2,2-trifluoroethoxy)phenyl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine (CID 159978681) is N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(5,6-difluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(6-fluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;6-[2,5-dimethyl-4-(trifluoromethyl)imidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;6-(6-methoxy-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;N-[4-(2,2,2-trifluoroethoxy)phenyl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine.
What is the SMILES notation for N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(5,6-difluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(6-fluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;6-[2,5-dimethyl-4-(trifluoromethyl)imidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;6-(6-methoxy-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;N-[4-(2,2,2-trifluoroethoxy)phenyl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine?
The canonical SMILES for N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(5,6-difluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(6-fluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;6-[2,5-dimethyl-4-(trifluoromethyl)imidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;6-(6-methoxy-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;N-[4-(2,2,2-trifluoroethoxy)phenyl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine is COc1ccc2nc(C)n(-c3cncc(Nc4ccc(C(F)(F)F)cc4)n3)c2c1.Cc1nc(C(F)(F)F)c(C)n1-c1cncc(Nc2ccc(C(F)(F)F)cc2)n1.Cc1nc2cc(F)c(F)cc2n1-c1cncc(Nc2ccc(OC(F)F)c(F)c2)n1.Cc1nc2ccc(F)cc2n1-c1cncc(Nc2ccc(OC(F)F)c(F)c2)n1.FC(F)(F)COc1ccc(Nc2cncc(-c3c(C(F)(F)F)nc4ccccn34)n2)cc1.
What is the InChIKey of N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(5,6-difluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(6-fluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;6-[2,5-dimethyl-4-(trifluoromethyl)imidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;6-(6-methoxy-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;N-[4-(2,2,2-trifluoroethoxy)phenyl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine?
The InChIKey is OFMGXJZEXFDOAU-UHFFFAOYSA-N. The full InChI is InChI=1S/C20H13F6N5O.C20H16F3N5O.C19H12F5N5O.C19H13F4N5O.C17H13F6N5/c21-19(22,23)11-32-13-6-4-12(5-7-13)28-15-10-27-9-14(29-15)17-18(20(24,25)26)30-16-3-1-2-8-31(16)17;1-12-25-16-8-7-15(29-2)9-17(16)28(12)19-11-24-10-18(27-19)26-14-5-3-13(4-6-14)20(21,22)23;1-9-26-14-5-11(20)12(21)6-15(14)29(9)18-8-25-7-17(28-18)27-10-2-3-16(13(22)4-10)30-19(23)24;1-10-25-14-4-2-11(20)6-15(14)28(10)18-9-24-8-17(27-18)26-12-3-5-16(13(21)7-12)29-19(22)23;1-9-15(17(21,22)23)25-10(2)28(9)14-8-24-7-13(27-14)26-12-5-3-11(4-6-12)16(18,19)20/h1-10H,11H2,(H,28,29);3-11H,1-2H3,(H,26,27);2-8,19H,1H3,(H,27,28);2-9,19H,1H3,(H,26,27);3-8H,1-2H3,(H,26,27).
What are the key properties of N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(5,6-difluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(6-fluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;6-[2,5-dimethyl-4-(trifluoromethyl)imidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;6-(6-methoxy-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;N-[4-(2,2,2-trifluoroethoxy)phenyl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine?
N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(5,6-difluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(6-fluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;6-[2,5-dimethyl-4-(trifluoromethyl)imidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;6-(6-methoxy-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;N-[4-(2,2,2-trifluoroethoxy)phenyl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine has a molecular weight of 2078.70 g/mol, XLogP of 25.08, 22 rotatable bonds, 5 hydrogen bond donors, and 29 hydrogen bond acceptors.
Where does this data come from?
All data for N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(5,6-difluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;N-[4-(difluoromethoxy)-3-fluorophenyl]-6-(6-fluoro-2-methylbenzimidazol-1-yl)pyrazin-2-amine;6-[2,5-dimethyl-4-(trifluoromethyl)imidazol-1-yl]-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;6-(6-methoxy-2-methylbenzimidazol-1-yl)-N-[4-(trifluoromethyl)phenyl]pyrazin-2-amine;N-[4-(2,2,2-trifluoroethoxy)phenyl]-6-[2-(trifluoromethyl)imidazo[1,2-a]pyridin-3-yl]pyrazin-2-amine is sourced from PubChem (CID 159978681), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).