6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclopentyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide

C131H112Cl2F18N28O12S6 — CID 160660692

About 6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclopentyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide

6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclopentyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide (PubChem CID 160660692) has the molecular formula C131H112Cl2F18N28O12S6 and a molecular weight of 2875.79 g/mol. Its IUPAC name is 6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclopentyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide.

Molecular Properties

• Compound Name: 6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclopentyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide
• PubChem CID: 160660692
• Molecular Formula: C131H112Cl2F18N28O12S6
• Molecular Weight: 2875.79 g/mol
• Exact Mass: 2872.64
• IUPAC Name: 6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclopentyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide
• SMILES: C[C@@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(Cl)ccc3n2-c2ccccn2)nc1)C(F)(F)F.C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(Cl)ccc3n2-c2ccccn2)nc1)C1CC1.C[C@H](NS(=O)(=O)c1cnc(-c2c(C#N)c3ccc(F)cc3n2C2CCC2)nc1)C(F)(F)F.C[C@H](NS(=O)(=O)c1cnc(-c2c(C#N)c3ccc(F)cc3n2C2CCCC2)nc1)C(F)(F)F.Cc1cc2c(C#N)c(-c3ccc(S(=O)(=O)NC(CF)CF)cn3)n(C3CCC3)c2cc1F.Cc1cc2c(C#N)c(-c3ccc(S(=O)(=O)N[C@@H](C)C(F)(F)F)cn3)n(C3CCC3)c2cc1F
• InChI: InChI=1S/C24H20ClN5O2S.C22H15ClF3N5O2S.C22H20F4N4O2S.C22H21F3N4O2S.C21H19F4N5O2S.C20H17F4N5O2S/c1-15(16-5-6-16)29-33(31,32)18-8-9-21(28-14-18)24-20(13-26)19-12-17(25)7-10-22(19)30(24)23-4-2-3-11-27-23;1-13(22(24,25)26)30-34(32,33)15-6-7-18(29-12-15)21-17(11-27)16-10-14(23)5-8-19(16)31(21)20-4-2-3-9-28-20;1-12-8-16-17(10-27)21(30(14-4-3-5-14)20(16)9-18(12)23)19-7-6-15(11-28-19)33(31,32)29-13(2)22(24,25)26;1-13-7-17-18(11-26)22(29(15-3-2-4-15)21(17)8-19(13)25)20-6-5-16(12-27-20)32(30,31)28-14(9-23)10-24;1-12(21(23,24)25)29-33(31,32)15-10-27-20(28-11-15)19-17(9-26)16-7-6-13(22)8-18(16)30(19)14-4-2-3-5-14;1-11(20(22,23)24)28-32(30,31)14-9-26-19(27-10-14)18-16(8-25)15-6-5-12(21)7-17(15)29(18)13-3-2-4-13/h2-4,7-12,14-16,29H,5-6H2,1H3;2-10,12-13,30H,1H3;6-9,11,13-14,29H,3-5H2,1-2H3;5-8,12,14-15,28H,2-4,9-10H2,1H3;6-8,10-12,14,29H,2-5H2,1H3;5-7,9-11,13,28H,2-4H2,1H3/t15-;2*13-;;12-;11-/m010.00/s1
• InChIKey: RLQCGABPTPRKJM-WLQYXMCMSA-N
• XLogP: 27.36
• TPSA: 578.24 Ų
• H-Bond Donors: 6
• H-Bond Acceptors: 34
• Rotatable Bonds: 33
• Heavy Atoms: 197
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2875.79
LogP ≤ 5	27.36
H-Bond Donors ≤ 5	6
H-Bond Acceptors ≤ 10	34

Frequently Asked Questions

What is the IUPAC name of 6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclopentyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide?

The IUPAC name of 6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclopentyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide (CID 160660692) is 6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclopentyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide.

What is the SMILES notation for 6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclopentyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide?

The canonical SMILES for 6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclopentyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide is C[C@@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(Cl)ccc3n2-c2ccccn2)nc1)C(F)(F)F.C[C@H](NS(=O)(=O)c1ccc(-c2c(C#N)c3cc(Cl)ccc3n2-c2ccccn2)nc1)C1CC1.C[C@H](NS(=O)(=O)c1cnc(-c2c(C#N)c3ccc(F)cc3n2C2CCC2)nc1)C(F)(F)F.C[C@H](NS(=O)(=O)c1cnc(-c2c(C#N)c3ccc(F)cc3n2C2CCCC2)nc1)C(F)(F)F.Cc1cc2c(C#N)c(-c3ccc(S(=O)(=O)NC(CF)CF)cn3)n(C3CCC3)c2cc1F.Cc1cc2c(C#N)c(-c3ccc(S(=O)(=O)N[C@@H](C)C(F)(F)F)cn3)n(C3CCC3)c2cc1F.

What is the InChIKey of 6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclopentyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide?

The InChIKey is RLQCGABPTPRKJM-WLQYXMCMSA-N. The full InChI is InChI=1S/C24H20ClN5O2S.C22H15ClF3N5O2S.C22H20F4N4O2S.C22H21F3N4O2S.C21H19F4N5O2S.C20H17F4N5O2S/c1-15(16-5-6-16)29-33(31,32)18-8-9-21(28-14-18)24-20(13-26)19-12-17(25)7-10-22(19)30(24)23-4-2-3-11-27-23;1-13(22(24,25)26)30-34(32,33)15-6-7-18(29-12-15)21-17(11-27)16-10-14(23)5-8-19(16)31(21)20-4-2-3-9-28-20;1-12-8-16-17(10-27)21(30(14-4-3-5-14)20(16)9-18(12)23)19-7-6-15(11-28-19)33(31,32)29-13(2)22(24,25)26;1-13-7-17-18(11-26)22(29(15-3-2-4-15)21(17)8-19(13)25)20-6-5-16(12-27-20)32(30,31)28-14(9-23)10-24;1-12(21(23,24)25)29-33(31,32)15-10-27-20(28-11-15)19-17(9-26)16-7-6-13(22)8-18(16)30(19)14-4-2-3-5-14;1-11(20(22,23)24)28-32(30,31)14-9-26-19(27-10-14)18-16(8-25)15-6-5-12(21)7-17(15)29(18)13-3-2-4-13/h2-4,7-12,14-16,29H,5-6H2,1H3;2-10,12-13,30H,1H3;6-9,11,13-14,29H,3-5H2,1-2H3;5-8,12,14-15,28H,2-4,9-10H2,1H3;6-8,10-12,14,29H,2-5H2,1H3;5-7,9-11,13,28H,2-4H2,1H3/t15-;2*13-;;12-;11-/m010.00/s1.

What are the key properties of 6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclopentyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide?

6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclopentyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide has a molecular weight of 2875.79 g/mol, XLogP of 27.36, 33 rotatable bonds, 6 hydrogen bond donors, and 34 hydrogen bond acceptors.

Where does this data come from?

All data for 6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(1S)-1-cyclopropylethyl]pyridine-3-sulfonamide;6-(5-chloro-3-cyano-1-pyridin-2-ylindol-2-yl)-N-[(2R)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclobutyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-(1,3-difluoropropan-2-yl)pyridine-3-sulfonamide;6-(3-cyano-1-cyclobutyl-6-fluoro-5-methylindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyridine-3-sulfonamide;2-(3-cyano-1-cyclopentyl-6-fluoroindol-2-yl)-N-[(2S)-1,1,1-trifluoropropan-2-yl]pyrimidine-5-sulfonamide is sourced from PubChem (CID 160660692), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).