4-[6-[4-(5-azaspiro[2.4]heptane-5-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-cyanopyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4,4-difluorocyclohexanecarbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3,3-dimethylpyrrolidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-methylpiperazine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-[(2R)-2-methylpyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-(morpholine-4-carbonyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile

C273H287F4N91O12 — CID 161055503

IUPAC4-[6-[4-(5-azaspiro[2.4]heptane-5-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-cyanopyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4,4-difluorocyclohexanecarbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3,3-dimethylpyrrolidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-methylpiperazine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-[(2R)-2-methylpyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-(morpholine-4-carbonyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile
SMILESCN1CCN(C(=O)N2CCN(c3ccc(-c4cc(-c5cnn(C)c5)cn5ncc(C#N)c45)cn3)CC2)CC1.COC[C@@H]1CCCN1C(=O)N1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.C[C@@H]1CCCN1C(=O)N1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)C5CCC(F)(F)CC5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCC(C)(C)C5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCC(F)CC5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCC6(CC6)C5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCCC(F)C5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCC[C@H]5C#N)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCOCC5)CC4)nc3)c3c(C#N)cnn3c2)cn1
InChIInChI=1S/C28H28F2N8O.C28H31N9O2.C28H29N9O.C28H31N9O.2C27H28FN9O.C27H30N10O.C27H26N10O.C27H29N9O.C26H27N9O2/c1-35-17-23(16-33-35)21-12-24(26-22(13-31)15-34-38(26)18-21)20-2-3-25(32-14-20)36-8-10-37(11-9-36)27(39)19-4-6-28(29,30)7-5-19;1-33-17-23(16-31-33)21-12-25(27-22(13-29)15-32-37(27)18-21)20-5-6-26(30-14-20)34-8-10-35(11-9-34)28(38)36-7-3-4-24(36)19-39-2;1-33-17-23(16-31-33)21-12-24(26-22(13-29)15-32-37(26)18-21)20-2-3-25(30-14-20)34-8-10-35(11-9-34)27(38)36-7-6-28(19-36)4-5-28;1-28(2)6-7-36(19-28)27(38)35-10-8-34(9-11-35)25-5-4-20(14-30-25)24-12-21(23-16-31-33(3)17-23)18-37-26(24)22(13-29)15-32-37;1-33-17-22(16-31-33)20-12-24(26-21(13-29)15-32-37(26)18-20)19-2-3-25(30-14-19)34-8-10-36(11-9-34)27(38)35-6-4-23(28)5-7-35;1-33-16-22(15-31-33)20-11-24(26-21(12-29)14-32-37(26)17-20)19-4-5-25(30-13-19)34-7-9-35(10-8-34)27(38)36-6-2-3-23(28)18-36;1-32-5-7-35(8-6-32)27(38)36-11-9-34(10-12-36)25-4-3-20(15-29-25)24-13-21(23-17-30-33(2)18-23)19-37-26(24)22(14-28)16-31-37;1-33-17-22(16-31-33)20-11-24(26-21(12-28)15-32-37(26)18-20)19-4-5-25(30-14-19)34-7-9-35(10-8-34)27(38)36-6-2-3-23(36)13-29;1-19-4-3-7-35(19)27(37)34-10-8-33(9-11-34)25-6-5-20(14-29-25)24-12-21(23-16-30-32(2)17-23)18-36-26(24)22(13-28)15-31-36;1-31-17-22(16-29-31)20-12-23(25-21(13-27)15-30-35(25)18-20)19-2-3-24(28-14-19)32-4-6-33(7-5-32)26(36)34-8-10-37-11-9-34/h2-3,12,14-19H,4-11H2,1H3;5-6,12,14-18,24H,3-4,7-11,19H2,1-2H3;2-3,12,14-18H,4-11,19H2,1H3;4-5,12,14-18H,6-11,19H2,1-3H3;2-3,12,14-18,23H,4-11H2,1H3;4-5,11,13-17,23H,2-3,6-10,18H2,1H3;3-4,13,15-19H,5-12H2,1-2H3;4-5,11,14-18,23H,2-3,6-10H2,1H3;5-6,12,14-19H,3-4,7-11H2,1-2H3;2-3,12,14-18H,4-11H2,1H3/t;24-;;;;;;23-;19-;/m.0.....01./s1
InChIKeyUCRRPGGJKUBRHX-ZJDQZSMWSA-N
MW5110.92 g/mol
LogP31.59
Rot. Bonds33

About 4-[6-[4-(5-azaspiro[2.4]heptane-5-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-cyanopyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4,4-difluorocyclohexanecarbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3,3-dimethylpyrrolidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-methylpiperazine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-[(2R)-2-methylpyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-(morpholine-4-carbonyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile

4-[6-[4-(5-azaspiro[2.4]heptane-5-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-cyanopyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4,4-difluorocyclohexanecarbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3,3-dimethylpyrrolidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-methylpiperazine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-[(2R)-2-methylpyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-(morpholine-4-carbonyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile (PubChem CID 161055503) has the molecular formula C273H287F4N91O12 and a molecular weight of 5110.92 g/mol. Its IUPAC name is 4-[6-[4-(5-azaspiro[2.4]heptane-5-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-cyanopyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4,4-difluorocyclohexanecarbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3,3-dimethylpyrrolidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-methylpiperazine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-[(2R)-2-methylpyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-(morpholine-4-carbonyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile.

Molecular Properties

Compound Name4-[6-[4-(5-azaspiro[2.4]heptane-5-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-cyanopyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4,4-difluorocyclohexanecarbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3,3-dimethylpyrrolidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-methylpiperazine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-[(2R)-2-methylpyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-(morpholine-4-carbonyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile
PubChem CID161055503
Molecular FormulaC273H287F4N91O12
Molecular Weight5110.92 g/mol
Exact Mass5107.46
IUPAC Name4-[6-[4-(5-azaspiro[2.4]heptane-5-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-cyanopyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4,4-difluorocyclohexanecarbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3,3-dimethylpyrrolidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-methylpiperazine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-[(2R)-2-methylpyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-(morpholine-4-carbonyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile
SMILESCN1CCN(C(=O)N2CCN(c3ccc(-c4cc(-c5cnn(C)c5)cn5ncc(C#N)c45)cn3)CC2)CC1.COC[C@@H]1CCCN1C(=O)N1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.C[C@@H]1CCCN1C(=O)N1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)C5CCC(F)(F)CC5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCC(C)(C)C5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCC(F)CC5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCC6(CC6)C5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCCC(F)C5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCC[C@H]5C#N)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCOCC5)CC4)nc3)c3c(C#N)cnn3c2)cn1
InChIInChI=1S/C28H28F2N8O.C28H31N9O2.C28H29N9O.C28H31N9O.2C27H28FN9O.C27H30N10O.C27H26N10O.C27H29N9O.C26H27N9O2/c1-35-17-23(16-33-35)21-12-24(26-22(13-31)15-34-38(26)18-21)20-2-3-25(32-14-20)36-8-10-37(11-9-36)27(39)19-4-6-28(29,30)7-5-19;1-33-17-23(16-31-33)21-12-25(27-22(13-29)15-32-37(27)18-21)20-5-6-26(30-14-20)34-8-10-35(11-9-34)28(38)36-7-3-4-24(36)19-39-2;1-33-17-23(16-31-33)21-12-24(26-22(13-29)15-32-37(26)18-21)20-2-3-25(30-14-20)34-8-10-35(11-9-34)27(38)36-7-6-28(19-36)4-5-28;1-28(2)6-7-36(19-28)27(38)35-10-8-34(9-11-35)25-5-4-20(14-30-25)24-12-21(23-16-31-33(3)17-23)18-37-26(24)22(13-29)15-32-37;1-33-17-22(16-31-33)20-12-24(26-21(13-29)15-32-37(26)18-20)19-2-3-25(30-14-19)34-8-10-36(11-9-34)27(38)35-6-4-23(28)5-7-35;1-33-16-22(15-31-33)20-11-24(26-21(12-29)14-32-37(26)17-20)19-4-5-25(30-13-19)34-7-9-35(10-8-34)27(38)36-6-2-3-23(28)18-36;1-32-5-7-35(8-6-32)27(38)36-11-9-34(10-12-36)25-4-3-20(15-29-25)24-13-21(23-17-30-33(2)18-23)19-37-26(24)22(14-28)16-31-37;1-33-17-22(16-31-33)20-11-24(26-21(12-28)15-32-37(26)18-20)19-4-5-25(30-14-19)34-7-9-35(10-8-34)27(38)36-6-2-3-23(36)13-29;1-19-4-3-7-35(19)27(37)34-10-8-33(9-11-34)25-6-5-20(14-29-25)24-12-21(23-16-30-32(2)17-23)18-36-26(24)22(13-28)15-31-36;1-31-17-22(16-29-31)20-12-23(25-21(13-27)15-30-35(25)18-20)19-2-3-24(28-14-19)32-4-6-33(7-5-32)26(36)34-8-10-37-11-9-34/h2-3,12,14-19H,4-11H2,1H3;5-6,12,14-18,24H,3-4,7-11,19H2,1-2H3;2-3,12,14-18H,4-11,19H2,1H3;4-5,12,14-18H,6-11,19H2,1-3H3;2-3,12,14-18,23H,4-11H2,1H3;4-5,11,13-17,23H,2-3,6-10,18H2,1H3;3-4,13,15-19H,5-12H2,1-2H3;4-5,11,14-18,23H,2-3,6-10H2,1H3;5-6,12,14-19H,3-4,7-11H2,1-2H3;2-3,12,14-18H,4-11H2,1H3/t;24-;;;;;;23-;19-;/m.0.....01./s1
InChIKeyUCRRPGGJKUBRHX-ZJDQZSMWSA-N
XLogP31.59
TPSA1028.15 Ų
H-Bond Donors
H-Bond Acceptors84
Rotatable Bonds33
Heavy Atoms380
Complexity—

Lipinski Rule of Five

3 violations

RuleValue
MW ≤ 5005110.92
LogP ≤ 531.59
H-Bond Donors ≤ 50
H-Bond Acceptors ≤ 1084

Analyze 4-[6-[4-(5-azaspiro[2.4]heptane-5-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-cyanopyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4,4-difluorocyclohexanecarbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3,3-dimethylpyrrolidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-methylpiperazine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-[(2R)-2-methylpyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-(morpholine-4-carbonyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile with MolForge

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Frequently Asked Questions

What is the IUPAC name of 4-[6-[4-(5-azaspiro[2.4]heptane-5-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-cyanopyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4,4-difluorocyclohexanecarbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3,3-dimethylpyrrolidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-methylpiperazine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-[(2R)-2-methylpyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-(morpholine-4-carbonyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile?
The IUPAC name of 4-[6-[4-(5-azaspiro[2.4]heptane-5-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-cyanopyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4,4-difluorocyclohexanecarbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3,3-dimethylpyrrolidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-methylpiperazine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-[(2R)-2-methylpyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-(morpholine-4-carbonyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile (CID 161055503) is 4-[6-[4-(5-azaspiro[2.4]heptane-5-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-cyanopyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4,4-difluorocyclohexanecarbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3,3-dimethylpyrrolidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-methylpiperazine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-[(2R)-2-methylpyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-(morpholine-4-carbonyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile.
What is the SMILES notation for 4-[6-[4-(5-azaspiro[2.4]heptane-5-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-cyanopyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4,4-difluorocyclohexanecarbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3,3-dimethylpyrrolidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-methylpiperazine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-[(2R)-2-methylpyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-(morpholine-4-carbonyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile?
The canonical SMILES for 4-[6-[4-(5-azaspiro[2.4]heptane-5-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-cyanopyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4,4-difluorocyclohexanecarbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3,3-dimethylpyrrolidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-methylpiperazine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-[(2R)-2-methylpyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-(morpholine-4-carbonyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile is CN1CCN(C(=O)N2CCN(c3ccc(-c4cc(-c5cnn(C)c5)cn5ncc(C#N)c45)cn3)CC2)CC1.COC[C@@H]1CCCN1C(=O)N1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.C[C@@H]1CCCN1C(=O)N1CCN(c2ccc(-c3cc(-c4cnn(C)c4)cn4ncc(C#N)c34)cn2)CC1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)C5CCC(F)(F)CC5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCC(C)(C)C5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCC(F)CC5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCC6(CC6)C5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCCC(F)C5)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCC[C@H]5C#N)CC4)nc3)c3c(C#N)cnn3c2)cn1.Cn1cc(-c2cc(-c3ccc(N4CCN(C(=O)N5CCOCC5)CC4)nc3)c3c(C#N)cnn3c2)cn1.
What is the InChIKey of 4-[6-[4-(5-azaspiro[2.4]heptane-5-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-cyanopyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4,4-difluorocyclohexanecarbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3,3-dimethylpyrrolidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-methylpiperazine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-[(2R)-2-methylpyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-(morpholine-4-carbonyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile?
The InChIKey is UCRRPGGJKUBRHX-ZJDQZSMWSA-N. The full InChI is InChI=1S/C28H28F2N8O.C28H31N9O2.C28H29N9O.C28H31N9O.2C27H28FN9O.C27H30N10O.C27H26N10O.C27H29N9O.C26H27N9O2/c1-35-17-23(16-33-35)21-12-24(26-22(13-31)15-34-38(26)18-21)20-2-3-25(32-14-20)36-8-10-37(11-9-36)27(39)19-4-6-28(29,30)7-5-19;1-33-17-23(16-31-33)21-12-25(27-22(13-29)15-32-37(27)18-21)20-5-6-26(30-14-20)34-8-10-35(11-9-34)28(38)36-7-3-4-24(36)19-39-2;1-33-17-23(16-31-33)21-12-24(26-22(13-29)15-32-37(26)18-21)20-2-3-25(30-14-20)34-8-10-35(11-9-34)27(38)36-7-6-28(19-36)4-5-28;1-28(2)6-7-36(19-28)27(38)35-10-8-34(9-11-35)25-5-4-20(14-30-25)24-12-21(23-16-31-33(3)17-23)18-37-26(24)22(13-29)15-32-37;1-33-17-22(16-31-33)20-12-24(26-21(13-29)15-32-37(26)18-20)19-2-3-25(30-14-19)34-8-10-36(11-9-34)27(38)35-6-4-23(28)5-7-35;1-33-16-22(15-31-33)20-11-24(26-21(12-29)14-32-37(26)17-20)19-4-5-25(30-13-19)34-7-9-35(10-8-34)27(38)36-6-2-3-23(28)18-36;1-32-5-7-35(8-6-32)27(38)36-11-9-34(10-12-36)25-4-3-20(15-29-25)24-13-21(23-17-30-33(2)18-23)19-37-26(24)22(14-28)16-31-37;1-33-17-22(16-31-33)20-11-24(26-21(12-28)15-32-37(26)18-20)19-4-5-25(30-14-19)34-7-9-35(10-8-34)27(38)36-6-2-3-23(36)13-29;1-19-4-3-7-35(19)27(37)34-10-8-33(9-11-34)25-6-5-20(14-29-25)24-12-21(23-16-30-32(2)17-23)18-36-26(24)22(13-28)15-31-36;1-31-17-22(16-29-31)20-12-23(25-21(13-27)15-30-35(25)18-20)19-2-3-24(28-14-19)32-4-6-33(7-5-32)26(36)34-8-10-37-11-9-34/h2-3,12,14-19H,4-11H2,1H3;5-6,12,14-18,24H,3-4,7-11,19H2,1-2H3;2-3,12,14-18H,4-11,19H2,1H3;4-5,12,14-18H,6-11,19H2,1-3H3;2-3,12,14-18,23H,4-11H2,1H3;4-5,11,13-17,23H,2-3,6-10,18H2,1H3;3-4,13,15-19H,5-12H2,1-2H3;4-5,11,14-18,23H,2-3,6-10H2,1H3;5-6,12,14-19H,3-4,7-11H2,1-2H3;2-3,12,14-18H,4-11H2,1H3/t;24-;;;;;;23-;19-;/m.0.....01./s1.
What are the key properties of 4-[6-[4-(5-azaspiro[2.4]heptane-5-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-cyanopyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4,4-difluorocyclohexanecarbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3,3-dimethylpyrrolidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-methylpiperazine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-[(2R)-2-methylpyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-(morpholine-4-carbonyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile?
4-[6-[4-(5-azaspiro[2.4]heptane-5-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-cyanopyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4,4-difluorocyclohexanecarbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3,3-dimethylpyrrolidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-methylpiperazine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-[(2R)-2-methylpyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-(morpholine-4-carbonyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile has a molecular weight of 5110.92 g/mol, XLogP of 31.59, 33 rotatable bonds, 0 hydrogen bond donors, and 84 hydrogen bond acceptors.
Where does this data come from?
All data for 4-[6-[4-(5-azaspiro[2.4]heptane-5-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-cyanopyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4,4-difluorocyclohexanecarbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3,3-dimethylpyrrolidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(3-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-fluoropiperidine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-[(2S)-2-(methoxymethyl)pyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;4-[6-[4-(4-methylpiperazine-1-carbonyl)piperazin-1-yl]-3-pyridinyl]-6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-[(2R)-2-methylpyrrolidine-1-carbonyl]piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile;6-(1-methylpyrazol-4-yl)-4-[6-[4-(morpholine-4-carbonyl)piperazin-1-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile is sourced from PubChem (CID 161055503), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).