2-amino-N-[4-[(4-aminocyclohexyl)methoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(1-methylazetidin-3-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-piperidin-4-yloxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

C93H94F15N35O11 — CID 161302824

About 2-amino-N-[4-[(4-aminocyclohexyl)methoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(1-methylazetidin-3-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-piperidin-4-yloxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide

2-amino-N-[4-[(4-aminocyclohexyl)methoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(1-methylazetidin-3-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-piperidin-4-yloxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (PubChem CID 161302824) has the molecular formula C93H94F15N35O11 and a molecular weight of 2162.98 g/mol. Its IUPAC name is 2-amino-N-[4-[(4-aminocyclohexyl)methoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(1-methylazetidin-3-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-piperidin-4-yloxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide.

Molecular Properties

• Compound Name: 2-amino-N-[4-[(4-aminocyclohexyl)methoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(1-methylazetidin-3-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-piperidin-4-yloxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
• PubChem CID: 161302824
• Molecular Formula: C93H94F15N35O11
• Molecular Weight: 2162.98 g/mol
• Exact Mass: 2161.76
• IUPAC Name: 2-amino-N-[4-[(4-aminocyclohexyl)methoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(1-methylazetidin-3-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-piperidin-4-yloxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
• SMILES: CN1CC(Oc2ccncc2NC(=O)c2c(N)nn3ccc(C(F)(F)F)nc23)C1.CN1CC[C@H](Oc2ccncc2NC(=O)c2c(N)nn3ccc(C(F)(F)F)nc23)C1.Nc1nn2ccc(C(F)(F)F)nc2c1C(=O)Nc1cnccc1OC1CCNCC1.Nc1nn2ccc(C(F)(F)F)nc2c1C(=O)Nc1cnccc1OCC1CCC(N)CC1.Nc1nn2ccc(C(F)(F)F)nc2c1C(=O)Nc1cnccc1OCCN1CC2(COC2)C1
• InChI: InChI=1S/C20H20F3N7O3.C20H22F3N7O2.2C18H18F3N7O2.C17H16F3N7O2/c21-20(22,23)14-2-4-30-17(27-14)15(16(24)28-30)18(31)26-12-7-25-3-1-13(12)33-6-5-29-8-19(9-29)10-32-11-19;21-20(22,23)15-6-8-30-18(28-15)16(17(25)29-30)19(31)27-13-9-26-7-5-14(13)32-10-11-1-3-12(24)4-2-11;1-27-6-3-10(9-27)30-12-2-5-23-8-11(12)24-17(29)14-15(22)26-28-7-4-13(18(19,20)21)25-16(14)28;19-18(20,21)13-4-8-28-16(26-13)14(15(22)27-28)17(29)25-11-9-24-7-3-12(11)30-10-1-5-23-6-2-10;1-26-7-9(8-26)29-11-2-4-22-6-10(11)23-16(28)13-14(21)25-27-5-3-12(17(18,19)20)24-15(13)27/h1-4,7H,5-6,8-11H2,(H2,24,28)(H,26,31);5-9,11-12H,1-4,10,24H2,(H2,25,29)(H,27,31);2,4-5,7-8,10H,3,6,9H2,1H3,(H2,22,26)(H,24,29);3-4,7-10,23H,1-2,5-6H2,(H2,22,27)(H,25,29);2-6,9H,7-8H2,1H3,(H2,21,25)(H,23,28)/t;;10-;;/m..0../s1
• InChIKey: VHVQVSADHKAMAA-NYARMHKXSA-N
• XLogP: 10.40
• TPSA: 594.15 Ų
• H-Bond Donors: 12
• H-Bond Acceptors: 41
• Rotatable Bonds: 23
• Heavy Atoms: 154
• Complexity: —

Lipinski Rule of Five

4 violations

Rule	Value
MW ≤ 500	2162.98
LogP ≤ 5	10.40
H-Bond Donors ≤ 5	12
H-Bond Acceptors ≤ 10	41

Frequently Asked Questions

What is the IUPAC name of 2-amino-N-[4-[(4-aminocyclohexyl)methoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(1-methylazetidin-3-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-piperidin-4-yloxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide?

The IUPAC name of 2-amino-N-[4-[(4-aminocyclohexyl)methoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(1-methylazetidin-3-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-piperidin-4-yloxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (CID 161302824) is 2-amino-N-[4-[(4-aminocyclohexyl)methoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(1-methylazetidin-3-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-piperidin-4-yloxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide.

What is the SMILES notation for 2-amino-N-[4-[(4-aminocyclohexyl)methoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(1-methylazetidin-3-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-piperidin-4-yloxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide?

The canonical SMILES for 2-amino-N-[4-[(4-aminocyclohexyl)methoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(1-methylazetidin-3-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-piperidin-4-yloxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide is CN1CC(Oc2ccncc2NC(=O)c2c(N)nn3ccc(C(F)(F)F)nc23)C1.CN1CC[C@H](Oc2ccncc2NC(=O)c2c(N)nn3ccc(C(F)(F)F)nc23)C1.Nc1nn2ccc(C(F)(F)F)nc2c1C(=O)Nc1cnccc1OC1CCNCC1.Nc1nn2ccc(C(F)(F)F)nc2c1C(=O)Nc1cnccc1OCC1CCC(N)CC1.Nc1nn2ccc(C(F)(F)F)nc2c1C(=O)Nc1cnccc1OCCN1CC2(COC2)C1.

What is the InChIKey of 2-amino-N-[4-[(4-aminocyclohexyl)methoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(1-methylazetidin-3-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-piperidin-4-yloxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide?

The InChIKey is VHVQVSADHKAMAA-NYARMHKXSA-N. The full InChI is InChI=1S/C20H20F3N7O3.C20H22F3N7O2.2C18H18F3N7O2.C17H16F3N7O2/c21-20(22,23)14-2-4-30-17(27-14)15(16(24)28-30)18(31)26-12-7-25-3-1-13(12)33-6-5-29-8-19(9-29)10-32-11-19;21-20(22,23)15-6-8-30-18(28-15)16(17(25)29-30)19(31)27-13-9-26-7-5-14(13)32-10-11-1-3-12(24)4-2-11;1-27-6-3-10(9-27)30-12-2-5-23-8-11(12)24-17(29)14-15(22)26-28-7-4-13(18(19,20)21)25-16(14)28;19-18(20,21)13-4-8-28-16(26-13)14(15(22)27-28)17(29)25-11-9-24-7-3-12(11)30-10-1-5-23-6-2-10;1-26-7-9(8-26)29-11-2-4-22-6-10(11)23-16(28)13-14(21)25-27-5-3-12(17(18,19)20)24-15(13)27/h1-4,7H,5-6,8-11H2,(H2,24,28)(H,26,31);5-9,11-12H,1-4,10,24H2,(H2,25,29)(H,27,31);2,4-5,7-8,10H,3,6,9H2,1H3,(H2,22,26)(H,24,29);3-4,7-10,23H,1-2,5-6H2,(H2,22,27)(H,25,29);2-6,9H,7-8H2,1H3,(H2,21,25)(H,23,28)/t;;10-;;/m..0../s1.

What are the key properties of 2-amino-N-[4-[(4-aminocyclohexyl)methoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(1-methylazetidin-3-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-piperidin-4-yloxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide?

2-amino-N-[4-[(4-aminocyclohexyl)methoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(1-methylazetidin-3-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-piperidin-4-yloxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide has a molecular weight of 2162.98 g/mol, XLogP of 10.40, 23 rotatable bonds, 12 hydrogen bond donors, and 41 hydrogen bond acceptors.

Where does this data come from?

All data for 2-amino-N-[4-[(4-aminocyclohexyl)methoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-(1-methylazetidin-3-yl)oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[(3S)-1-methylpyrrolidin-3-yl]oxy-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-[4-[2-(2-oxa-6-azaspiro[3.3]heptan-6-yl)ethoxy]-3-pyridinyl]-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide;2-amino-N-(4-piperidin-4-yloxy-3-pyridinyl)-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide is sourced from PubChem (CID 161302824), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).