1-(cyclopropylmethyl)-8-(dimethylamino)-3-[(1-hydroxycyclopropyl)methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-[[1-(2-oxopropyl)cyclopropyl]methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1,3-bis(2-methylsulfonylethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1-[(1-hydroxycyclobutyl)methyl]-3-(2-hydroxy-2-methylpropyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one

C154H226N24O14S2 — CID 162085680

About 1-(cyclopropylmethyl)-8-(dimethylamino)-3-[(1-hydroxycyclopropyl)methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-[[1-(2-oxopropyl)cyclopropyl]methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1,3-bis(2-methylsulfonylethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1-[(1-hydroxycyclobutyl)methyl]-3-(2-hydroxy-2-methylpropyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one

1-(cyclopropylmethyl)-8-(dimethylamino)-3-[(1-hydroxycyclopropyl)methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-[[1-(2-oxopropyl)cyclopropyl]methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1,3-bis(2-methylsulfonylethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1-[(1-hydroxycyclobutyl)methyl]-3-(2-hydroxy-2-methylpropyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one (PubChem CID 162085680) has the molecular formula C154H226N24O14S2 and a molecular weight of 2701.79 g/mol. Its IUPAC name is 1-(cyclopropylmethyl)-8-(dimethylamino)-3-[(1-hydroxycyclopropyl)methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-[[1-(2-oxopropyl)cyclopropyl]methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1,3-bis(2-methylsulfonylethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1-[(1-hydroxycyclobutyl)methyl]-3-(2-hydroxy-2-methylpropyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one.

Molecular Properties

• Compound Name: 1-(cyclopropylmethyl)-8-(dimethylamino)-3-[(1-hydroxycyclopropyl)methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-[[1-(2-oxopropyl)cyclopropyl]methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1,3-bis(2-methylsulfonylethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1-[(1-hydroxycyclobutyl)methyl]-3-(2-hydroxy-2-methylpropyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one
• PubChem CID: 162085680
• Molecular Formula: C154H226N24O14S2
• Molecular Weight: 2701.79 g/mol
• Exact Mass: 2699.72
• IUPAC Name: 1-(cyclopropylmethyl)-8-(dimethylamino)-3-[(1-hydroxycyclopropyl)methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-[[1-(2-oxopropyl)cyclopropyl]methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1,3-bis(2-methylsulfonylethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1-[(1-hydroxycyclobutyl)methyl]-3-(2-hydroxy-2-methylpropyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one
• SMILES: CC(=O)CC1(CN2CC3(CCC(c4ccccc4)(N(C)C)CC3)N(CC3CC3)C2=O)CC1.CN(C)C1(c2ccccc2)CCC2(CC1)CN(CC(C)(C)O)C(=O)N2CC1(O)CCC1.CN(C)C1(c2ccccc2)CCC2(CC1)CN(CC1(O)CC1)C(=O)N2CC1CC1.CN(C)C1(c2ccccc2)CCC2(CC1)CN(CC1CCN(c3cncnc3)CC1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(CC1CCN(c3cncnc3)CC1)C(=O)N2CC1CC1.CN(C)C1(c2ccccc2)CCC2(CC1)CN(CCS(C)(=O)=O)C(=O)N2CCS(C)(=O)=O
• InChI: InChI=1S/C30H42N6O.C27H39N3O2.C26H36N6O.C25H39N3O3.C24H35N3O2.C22H35N3O5S2/c1-33(2)30(26-6-4-3-5-7-26)14-12-29(13-15-30)22-35(28(37)36(29)21-24-8-9-24)20-25-10-16-34(17-11-25)27-18-31-23-32-19-27;1-21(31)17-25(11-12-25)19-29-20-26(30(24(29)32)18-22-9-10-22)13-15-27(16-14-26,28(2)3)23-7-5-4-6-8-23;1-30(2)26(22-6-4-3-5-7-22)12-10-25(11-13-26)19-32(24(33)29-25)18-21-8-14-31(15-9-21)23-16-27-20-28-17-23;1-22(2,30)17-27-18-23(28(21(27)29)19-24(31)11-8-12-24)13-15-25(16-14-23,26(3)4)20-9-6-5-7-10-20;1-25(2)24(20-6-4-3-5-7-20)14-10-22(11-15-24)17-26(18-23(29)12-13-23)21(28)27(22)16-19-8-9-19;1-23(2)22(19-8-6-5-7-9-19)12-10-21(11-13-22)18-24(14-16-31(3,27)28)20(26)25(21)15-17-32(4,29)30/h3-7,18-19,23-25H,8-17,20-22H2,1-2H3;4-8,22H,9-20H2,1-3H3;3-7,16-17,20-21H,8-15,18-19H2,1-2H3,(H,29,33);5-7,9-10,30-31H,8,11-19H2,1-4H3;3-7,19,29H,8-18H2,1-2H3;5-9H,10-18H2,1-4H3
• InChIKey: ZCXSISFAIJDGFE-UHFFFAOYSA-N
• XLogP: 20.95
• TPSA: 373.61 Ų
• H-Bond Donors: 4
• H-Bond Acceptors: 26
• Rotatable Bonds: 40
• Heavy Atoms: 194
• Complexity: —

Lipinski Rule of Five

3 violations

Rule	Value
MW ≤ 500	2701.79
LogP ≤ 5	20.95
H-Bond Donors ≤ 5	4
H-Bond Acceptors ≤ 10	26

Frequently Asked Questions

What is the IUPAC name of 1-(cyclopropylmethyl)-8-(dimethylamino)-3-[(1-hydroxycyclopropyl)methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-[[1-(2-oxopropyl)cyclopropyl]methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1,3-bis(2-methylsulfonylethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1-[(1-hydroxycyclobutyl)methyl]-3-(2-hydroxy-2-methylpropyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one?

The IUPAC name of 1-(cyclopropylmethyl)-8-(dimethylamino)-3-[(1-hydroxycyclopropyl)methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-[[1-(2-oxopropyl)cyclopropyl]methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1,3-bis(2-methylsulfonylethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1-[(1-hydroxycyclobutyl)methyl]-3-(2-hydroxy-2-methylpropyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one (CID 162085680) is 1-(cyclopropylmethyl)-8-(dimethylamino)-3-[(1-hydroxycyclopropyl)methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-[[1-(2-oxopropyl)cyclopropyl]methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1,3-bis(2-methylsulfonylethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1-[(1-hydroxycyclobutyl)methyl]-3-(2-hydroxy-2-methylpropyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one.

What is the SMILES notation for 1-(cyclopropylmethyl)-8-(dimethylamino)-3-[(1-hydroxycyclopropyl)methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-[[1-(2-oxopropyl)cyclopropyl]methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1,3-bis(2-methylsulfonylethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1-[(1-hydroxycyclobutyl)methyl]-3-(2-hydroxy-2-methylpropyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one?

The canonical SMILES for 1-(cyclopropylmethyl)-8-(dimethylamino)-3-[(1-hydroxycyclopropyl)methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-[[1-(2-oxopropyl)cyclopropyl]methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1,3-bis(2-methylsulfonylethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1-[(1-hydroxycyclobutyl)methyl]-3-(2-hydroxy-2-methylpropyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one is CC(=O)CC1(CN2CC3(CCC(c4ccccc4)(N(C)C)CC3)N(CC3CC3)C2=O)CC1.CN(C)C1(c2ccccc2)CCC2(CC1)CN(CC(C)(C)O)C(=O)N2CC1(O)CCC1.CN(C)C1(c2ccccc2)CCC2(CC1)CN(CC1(O)CC1)C(=O)N2CC1CC1.CN(C)C1(c2ccccc2)CCC2(CC1)CN(CC1CCN(c3cncnc3)CC1)C(=O)N2.CN(C)C1(c2ccccc2)CCC2(CC1)CN(CC1CCN(c3cncnc3)CC1)C(=O)N2CC1CC1.CN(C)C1(c2ccccc2)CCC2(CC1)CN(CCS(C)(=O)=O)C(=O)N2CCS(C)(=O)=O.

What is the InChIKey of 1-(cyclopropylmethyl)-8-(dimethylamino)-3-[(1-hydroxycyclopropyl)methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-[[1-(2-oxopropyl)cyclopropyl]methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1,3-bis(2-methylsulfonylethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1-[(1-hydroxycyclobutyl)methyl]-3-(2-hydroxy-2-methylpropyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one?

The InChIKey is ZCXSISFAIJDGFE-UHFFFAOYSA-N. The full InChI is InChI=1S/C30H42N6O.C27H39N3O2.C26H36N6O.C25H39N3O3.C24H35N3O2.C22H35N3O5S2/c1-33(2)30(26-6-4-3-5-7-26)14-12-29(13-15-30)22-35(28(37)36(29)21-24-8-9-24)20-25-10-16-34(17-11-25)27-18-31-23-32-19-27;1-21(31)17-25(11-12-25)19-29-20-26(30(24(29)32)18-22-9-10-22)13-15-27(16-14-26,28(2)3)23-7-5-4-6-8-23;1-30(2)26(22-6-4-3-5-7-22)12-10-25(11-13-26)19-32(24(33)29-25)18-21-8-14-31(15-9-21)23-16-27-20-28-17-23;1-22(2,30)17-27-18-23(28(21(27)29)19-24(31)11-8-12-24)13-15-25(16-14-23,26(3)4)20-9-6-5-7-10-20;1-25(2)24(20-6-4-3-5-7-20)14-10-22(11-15-24)17-26(18-23(29)12-13-23)21(28)27(22)16-19-8-9-19;1-23(2)22(19-8-6-5-7-9-19)12-10-21(11-13-22)18-24(14-16-31(3,27)28)20(26)25(21)15-17-32(4,29)30/h3-7,18-19,23-25H,8-17,20-22H2,1-2H3;4-8,22H,9-20H2,1-3H3;3-7,16-17,20-21H,8-15,18-19H2,1-2H3,(H,29,33);5-7,9-10,30-31H,8,11-19H2,1-4H3;3-7,19,29H,8-18H2,1-2H3;5-9H,10-18H2,1-4H3.

What are the key properties of 1-(cyclopropylmethyl)-8-(dimethylamino)-3-[(1-hydroxycyclopropyl)methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-[[1-(2-oxopropyl)cyclopropyl]methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1,3-bis(2-methylsulfonylethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1-[(1-hydroxycyclobutyl)methyl]-3-(2-hydroxy-2-methylpropyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one?

1-(cyclopropylmethyl)-8-(dimethylamino)-3-[(1-hydroxycyclopropyl)methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-[[1-(2-oxopropyl)cyclopropyl]methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1,3-bis(2-methylsulfonylethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1-[(1-hydroxycyclobutyl)methyl]-3-(2-hydroxy-2-methylpropyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one has a molecular weight of 2701.79 g/mol, XLogP of 20.95, 40 rotatable bonds, 4 hydrogen bond donors, and 26 hydrogen bond acceptors.

Where does this data come from?

All data for 1-(cyclopropylmethyl)-8-(dimethylamino)-3-[(1-hydroxycyclopropyl)methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-3-[[1-(2-oxopropyl)cyclopropyl]methyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;1-(cyclopropylmethyl)-8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1,3-bis(2-methylsulfonylethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-1-[(1-hydroxycyclobutyl)methyl]-3-(2-hydroxy-2-methylpropyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one;8-(dimethylamino)-8-phenyl-3-[(1-pyrimidin-5-ylpiperidin-4-yl)methyl]-1,3-diazaspiro[4.5]decan-2-one is sourced from PubChem (CID 162085680), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).