Tovorafenib

Name: Tovorafenib — Molecular Data
Creator: MolForge
License: https://creativecommons.org/publicdomain/zero/1.0/

C₁₇H₁₂Cl₂F₃N₇O₂S — CID 25161177

💊View drug profile → tovorafenib

Data last refreshed: 2026-04-15 (MolForge compound catalog, from PubChem)

IUPAC2-[(1R)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-1,3-thiazole-5-carboxamide

SMILESC[C@@H](NC(=O)c1ncnc(N)c1Cl)c1ncc(C(=O)Nc2cc(C(F)(F)F)c(Cl)cn2)s1

InChIInChI=1S/C17H12Cl2F3N7O2S/c1-6(28-15(31)12-11(19)13(23)27-5-26-12)16-25-4-9(32-16)14(30)29-10-2-7(17(20,21)22)8(18)3-24-10/h2-6H,1H3,(H,28,31)(H2,23,26,27)(H,24,29,30)/t6-/m1/s1

InChIKeyVWMJHAFYPMOMGF-ZCFIWIBFSA-N

MW506.30 g/mol

LogP3.98

Rot. Bonds5

About Tovorafenib

Tovorafenib (PubChem CID 25161177) has the molecular formula C₁₇H₁₂Cl₂F₃N₇O₂S and a molecular weight of 506.30 g/mol. Its IUPAC name is 2-[(1R)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-1,3-thiazole-5-carboxamide.

Molecular Properties

Compound Name	Tovorafenib
PubChem CID	25161177
Molecular Formula	C₁₇H₁₂Cl₂F₃N₇O₂S
Molecular Weight	506.30 g/mol
Exact Mass	505.01
IUPAC Name	2-[(1R)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-1,3-thiazole-5-carboxamide
SMILES	C[C@@H](NC(=O)c1ncnc(N)c1Cl)c1ncc(C(=O)Nc2cc(C(F)(F)F)c(Cl)cn2)s1
InChI	InChI=1S/C17H12Cl2F3N7O2S/c1-6(28-15(31)12-11(19)13(23)27-5-26-12)16-25-4-9(32-16)14(30)29-10-2-7(17(20,21)22)8(18)3-24-10/h2-6H,1H3,(H,28,31)(H2,23,26,27)(H,24,29,30)/t6-/m1/s1
InChIKey	VWMJHAFYPMOMGF-ZCFIWIBFSA-N
XLogP	3.98
TPSA	135.78 Å²
H-Bond Donors	3
H-Bond Acceptors	8
Rotatable Bonds	5
Heavy Atoms	32
Complexity	—

Lipinski Rule of Five

1 violation

Rule	Value
MW ≤ 500	506.30
LogP ≤ 5	3.98
H-Bond Donors ≤ 5	3
H-Bond Acceptors ≤ 10	8

Related Compounds

Frequently Asked Questions

What is the IUPAC name of Tovorafenib?

The IUPAC name of Tovorafenib (CID 25161177) is 2-[(1R)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-N-[5-chloro-4-(trifluoromethyl)-2-pyridinyl]-1,3-thiazole-5-carboxamide.

What is the SMILES notation for Tovorafenib?

The canonical SMILES for Tovorafenib is C[C@@H](NC(=O)c1ncnc(N)c1Cl)c1ncc(C(=O)Nc2cc(C(F)(F)F)c(Cl)cn2)s1.

What is the InChIKey of Tovorafenib?

The InChIKey is VWMJHAFYPMOMGF-ZCFIWIBFSA-N. The full InChI is InChI=1S/C17H12Cl2F3N7O2S/c1-6(28-15(31)12-11(19)13(23)27-5-26-12)16-25-4-9(32-16)14(30)29-10-2-7(17(20,21)22)8(18)3-24-10/h2-6H,1H3,(H,28,31)(H2,23,26,27)(H,24,29,30)/t6-/m1/s1.

What are the key properties of Tovorafenib?

Tovorafenib has a molecular weight of 506.30 g/mol, XLogP of 3.98, 5 rotatable bonds, 3 hydrogen bond donors, and 8 hydrogen bond acceptors.

Where does this data come from?

All data for Tovorafenib is sourced from PubChem (CID 25161177), the world's largest open chemistry database maintained by the National Library of Medicine (NIH).

Browse: Molecules: T · all molecules A–Z · drugs A–Z · protein targets A–Z.

Sources

PubChem CID 25161177 — identifiers, structure, computed properties (public domain)
DrugCentral drug card 5819 — approved-drug record (CC BY-SA 4.0)

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