Calcium and integrin-binding family member 4 (CIB4)
Homo sapiens — UniProt A0PJX0
Data last refreshed: (UniProt release unknown)
Key facts
Calcium and integrin-binding family member 4 (CIB4) is a protein from Homo sapiens identified by UniProt accession A0PJX0, 185 residues long. MolForge cross-references it against 0 known binders and 119 disease associations.
- UniProt accession: A0PJX0; gene symbol CIB4.
- Organism: Homo sapiens.
- Length: 185 amino acids.
- Top disease associations (Open Targets): vital capacity, hypertension and azoospermia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Calcium and integrin-binding family member 4 |
|---|---|
| UniProt accession | A0PJX0 |
| Gene | CIB4 |
| Organism | Homo sapiens |
| Length | 185 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (119)
Diseases linked to this target (Open Targets).
- vital capacity · score 0.37
- hypertension · score 0.11
- azoospermia · score 0.10
- systolic blood pressure · score 0.10
- diastolic blood pressure · score 0.09
- mean arterial pressure · score 0.09
- pulse pressure measurement · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- blood pressure · score 0.08
- partial chromosome Y deletion · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A0PJX0-F1 | alphafold | PREDICTED | 89.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A0PJX0.
Amino-acid sequence (185 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CIB4?
The strongest Open Targets associations for CIB4 are vital capacity, hypertension, azoospermia, systolic blood pressure and diastolic blood pressure.
How long is the CIB4 protein?
The Homo sapiens CIB4 protein (UniProt A0PJX0) is 185 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A0PJX0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A0PJX0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.