Protein shisa-3 homolog (SHISA3)
Homo sapiens — UniProt A0PJX4
Data last refreshed: (UniProt release unknown)
Key facts
Protein shisa-3 homolog (SHISA3) is a protein from Homo sapiens identified by UniProt accession A0PJX4, 238 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: A0PJX4; gene symbol SHISA3.
- Organism: Homo sapiens.
- Length: 238 amino acids.
- Top disease associations (Open Targets): arterial stiffness measurement, appendicular lean mass and creatinine measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein shisa-3 homolog |
|---|---|
| UniProt accession | A0PJX4 |
| Gene | SHISA3 |
| Organism | Homo sapiens |
| Length | 238 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- arterial stiffness measurement · score 0.23
- appendicular lean mass · score 0.21
- creatinine measurement · score 0.20
- Snoring · score 0.20
- snoring measurement · score 0.15
- glomerular filtration rate · score 0.15
- breast cancer · score 0.07
- laryngeal squamous cell carcinoma · score 0.06
- adolescent idiopathic scoliosis · score 0.05
- neoplasm · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A0PJX4-F1 | alphafold | PREDICTED | 67.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A0PJX4.
Amino-acid sequence (238 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SHISA3?
The strongest Open Targets associations for SHISA3 are arterial stiffness measurement, appendicular lean mass, creatinine measurement, Snoring and snoring measurement.
How long is the SHISA3 protein?
The Homo sapiens SHISA3 protein (UniProt A0PJX4) is 238 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A0PJX4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A0PJX4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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