Clarin-2 (CLRN2)

About Clarin-2

Clarin-2 (CLRN2) is a protein from Homo sapiens identified by UniProt accession A0PK11, 232 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	Clarin-2
UniProt accession	A0PK11
Gene	CLRN2
Organism	Homo sapiens
Length	232 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

hearing loss, autosomal recessive 117 · score 0.48
age-related hearing impairment · score 0.42
blood protein measurement · score 0.35
hearing loss · score 0.34
diet measurement · score 0.34
Hearing abnormality · score 0.30
BH4-deficient hyperphenylalaninemia A · score 0.15
cortical thickness · score 0.12
deafness · score 0.10
mathematical ability · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A0PK11-F1	alphafold	PREDICTED	91.30	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for A0PK11.

Amino-acid sequence (232 residues)

MPGWFKKAWY GLASLLSFSS FILIIVALVV PHWLSGKILC QTGVDLVNAT DRELVKFIGD IYYGLFRGCK VRQCGLGGRQ SQFTIFPHLV KELNAGLHVM ILLLLFLALA LALVSMGFAI LNMIQVPYRA VSGPGGICLW NVLAGGVVAL AIASFVAAVK FHDLTERIAN FQEKLFQFVV VEEQYEESFW ICVASASAHA ANLVVVAISQ IPLPEIKTKI EEATVTAEDI LY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards