Leukemia NUP98 fusion partner 1 (LNP1)
Homo sapiens — UniProt A1A4G5
Data last refreshed: (UniProt release unknown)
Key facts
Leukemia NUP98 fusion partner 1 (LNP1) is a protein from Homo sapiens identified by UniProt accession A1A4G5, 178 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.
- UniProt accession: A1A4G5; gene symbol LNP1.
- Organism: Homo sapiens.
- Length: 178 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neoplasm and cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leukemia NUP98 fusion partner 1 |
|---|---|
| UniProt accession | A1A4G5 |
| Gene | LNP1 |
| Organism | Homo sapiens |
| Length | 178 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (13)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.17
- neoplasm · score 0.01
- cancer · score 0.01
- allergic asthma · score 0.00
- COVID-19 · score 0.00
- Obesity · score 0.00
- ependymoma · score 0.00
- skin infection · score 0.00
- infect · score 0.00
- infection · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A1A4G5-F1 | alphafold | PREDICTED | 63.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A1A4G5.
Amino-acid sequence (178 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LNP1?
The strongest Open Targets associations for LNP1 are neurodegenerative disease, neoplasm, cancer, allergic asthma and COVID-19.
How long is the LNP1 protein?
The Homo sapiens LNP1 protein (UniProt A1A4G5) is 178 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A1A4G5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A1A4G5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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