Rho GTPase-activating protein 10 (ARHGAP10)
Homo sapiens — UniProt A1A4S6
Data last refreshed: (UniProt release unknown)
Key facts
Rho GTPase-activating protein 10 (ARHGAP10) is a protein from Homo sapiens identified by UniProt accession A1A4S6, 786 residues long. MolForge cross-references it against 0 known binders and 122 disease associations.
- UniProt accession: A1A4S6; gene symbol ARHGAP10.
- Organism: Homo sapiens.
- Length: 786 amino acids.
- Top disease associations (Open Targets): mean platelet volume, sex hormone-binding globulin measurement and hemoglobin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rho GTPase-activating protein 10 |
|---|---|
| UniProt accession | A1A4S6 |
| Gene | ARHGAP10 |
| Organism | Homo sapiens |
| Length | 786 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (122)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.56
- sex hormone-binding globulin measurement · score 0.45
- hemoglobin measurement · score 0.45
- alkaline phosphatase measurement · score 0.43
- hematocrit · score 0.43
- erythrocyte count · score 0.41
- atrial fibrillation · score 0.39
- serum gamma-glutamyl transferase measurement · score 0.38
- testosterone measurement · score 0.37
- diet measurement · score 0.36
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A1A4S6-F1 | alphafold | PREDICTED | 79.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A1A4S6.
Amino-acid sequence (786 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARHGAP10?
The strongest Open Targets associations for ARHGAP10 are mean platelet volume, sex hormone-binding globulin measurement, hemoglobin measurement, alkaline phosphatase measurement and hematocrit.
How long is the ARHGAP10 protein?
The Homo sapiens ARHGAP10 protein (UniProt A1A4S6) is 786 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A1A4S6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A1A4S6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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