Cilia- and flagella-associated protein 119 (CFAP119)
Homo sapiens — UniProt A1A4V9
Data last refreshed: (UniProt release unknown)
Key facts
Cilia- and flagella-associated protein 119 (CFAP119) is a protein from Homo sapiens identified by UniProt accession A1A4V9, 331 residues long. MolForge cross-references it against 0 known binders and 149 disease associations.
- UniProt accession: A1A4V9; gene symbol CFAP119.
- Organism: Homo sapiens.
- Length: 331 amino acids.
- Top disease associations (Open Targets): Glycogen storage disease due to phosphorylase kinase deficiency, serum albumin measurement and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cilia- and flagella-associated protein 119 |
|---|---|
| UniProt accession | A1A4V9 |
| Gene | CFAP119 |
| Organism | Homo sapiens |
| Length | 331 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (149)
Diseases linked to this target (Open Targets).
- Glycogen storage disease due to phosphorylase kinase deficiency · score 0.18
- serum albumin measurement · score 0.16
- platelet count · score 0.13
- C-reactive protein measurement · score 0.12
- azoospermia · score 0.10
- testosterone measurement · score 0.10
- vital capacity · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- juvenile idiopathic arthritis · score 0.08
- lymphocyte count · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A1A4V9-F1 | alphafold | PREDICTED | 73.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A1A4V9.
Amino-acid sequence (331 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CFAP119?
The strongest Open Targets associations for CFAP119 are Glycogen storage disease due to phosphorylase kinase deficiency, serum albumin measurement, platelet count, C-reactive protein measurement and azoospermia.
How long is the CFAP119 protein?
The Homo sapiens CFAP119 protein (UniProt A1A4V9) is 331 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A1A4V9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A1A4V9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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