Immunity-related GTPase family M protein (IRGM)
Homo sapiens — UniProt A1A4Y4
Data last refreshed: (UniProt release unknown)
Key facts
Immunity-related GTPase family M protein (IRGM) is a protein from Homo sapiens identified by UniProt accession A1A4Y4, 181 residues long. MolForge cross-references it against 0 known binders and 146 disease associations.
- UniProt accession: A1A4Y4; gene symbol IRGM.
- Organism: Homo sapiens.
- Length: 181 amino acids.
- Top disease associations (Open Targets): inflammatory bowel disease, Crohn's disease and ulcerative colitis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Immunity-related GTPase family M protein |
|---|---|
| UniProt accession | A1A4Y4 |
| Gene | IRGM |
| Organism | Homo sapiens |
| Length | 181 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (146)
Diseases linked to this target (Open Targets).
- inflammatory bowel disease · score 0.45
- Crohn's disease · score 0.35
- ulcerative colitis · score 0.29
- psoriasis · score 0.22
- ankylosing spondylitis · score 0.22
- sclerosing cholangitis · score 0.22
- rheumatoid arthritis · score 0.17
- infection · score 0.09
- infect · score 0.09
- melanoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A1A4Y4-F1 | alphafold | PREDICTED | 84.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A1A4Y4.
Amino-acid sequence (181 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IRGM?
The strongest Open Targets associations for IRGM are inflammatory bowel disease, Crohn's disease, ulcerative colitis, psoriasis and ankylosing spondylitis.
How long is the IRGM protein?
The Homo sapiens IRGM protein (UniProt A1A4Y4) is 181 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A1A4Y4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A1A4Y4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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