Odontogenic ameloblast-associated protein (ODAM)
Homo sapiens — UniProt A1E959
Data last refreshed: (UniProt release unknown)
Key facts
Odontogenic ameloblast-associated protein (ODAM) is a protein from Homo sapiens identified by UniProt accession A1E959, 279 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.
- UniProt accession: A1E959; gene symbol ODAM.
- Organism: Homo sapiens.
- Length: 279 amino acids.
- Top disease associations (Open Targets): AL amyloidosis, melanoma and Barrett's esophagus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Odontogenic ameloblast-associated protein |
|---|---|
| UniProt accession | A1E959 |
| Gene | ODAM |
| Organism | Homo sapiens |
| Length | 279 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (49)
Diseases linked to this target (Open Targets).
- AL amyloidosis · score 0.46
- melanoma · score 0.06
- Barrett's esophagus · score 0.06
- hepatocellular carcinoma · score 0.06
- periodontitis · score 0.05
- esophageal adenocarcinoma · score 0.04
- heel bone mineral density · score 0.03
- cancer · score 0.03
- Crohn's disease · score 0.03
- neoplasm · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A1E959-F1 | alphafold | PREDICTED | 42.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A1E959.
Amino-acid sequence (279 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ODAM?
The strongest Open Targets associations for ODAM are AL amyloidosis, melanoma, Barrett's esophagus, hepatocellular carcinoma and periodontitis.
How long is the ODAM protein?
The Homo sapiens ODAM protein (UniProt A1E959) is 279 amino acids long.
Browse: Targets: O · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A1E959 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A1E959 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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