2-hydroxyacyl-CoA lyase 2 (HACL2)
Homo sapiens — UniProt A1L0T0
Data last refreshed: (UniProt release unknown)
Key facts
2-hydroxyacyl-CoA lyase 2 (HACL2) is a protein from Homo sapiens identified by UniProt accession A1L0T0, 632 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: A1L0T0; gene symbol HACL2.
- Organism: Homo sapiens.
- Length: 632 amino acids.
- Top disease associations (Open Targets): pulse pressure measurement, tuberculosis and male infertility.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 2-hydroxyacyl-CoA lyase 2 |
|---|---|
| UniProt accession | A1L0T0 |
| Gene | HACL2 |
| Organism | Homo sapiens |
| Length | 632 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- pulse pressure measurement · score 0.07
- tuberculosis · score 0.02
- male infertility · score 0.01
- hepatocellular carcinoma · score 0.01
- lung adenocarcinoma · score 0.01
- respiratory system disease · score 0.01
- psoriasis · score 0.01
- Rheumatoid arthritis · score 0.01
- Stroke · score 0.00
- aspergillosis · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A1L0T0-F1 | alphafold | PREDICTED | 94.36 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A1L0T0.
Amino-acid sequence (632 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HACL2?
The strongest Open Targets associations for HACL2 are pulse pressure measurement, tuberculosis, male infertility, hepatocellular carcinoma and lung adenocarcinoma.
How long is the HACL2 protein?
The Homo sapiens HACL2 protein (UniProt A1L0T0) is 632 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A1L0T0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A1L0T0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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