Immunoglobulin superfamily member 23 (IGSF23)
Homo sapiens — UniProt A1L1A6
Data last refreshed: (UniProt release unknown)
Key facts
Immunoglobulin superfamily member 23 (IGSF23) is a protein from Homo sapiens identified by UniProt accession A1L1A6, 192 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.
- UniProt accession: A1L1A6; gene symbol IGSF23.
- Organism: Homo sapiens.
- Length: 192 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean platelet volume and leukocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Immunoglobulin superfamily member 23 |
|---|---|
| UniProt accession | A1L1A6 |
| Gene | IGSF23 |
| Organism | Homo sapiens |
| Length | 192 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (18)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.45
- mean platelet volume · score 0.32
- leukocyte count · score 0.11
- lymphocyte count · score 0.09
- platelet count · score 0.09
- platelet component distribution width · score 0.06
- monocyte count · score 0.06
- multiple sclerosis · score 0.05
- Crohn's disease · score 0.04
- blood protein measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A1L1A6-F1 | alphafold | PREDICTED | 78.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A1L1A6.
Amino-acid sequence (192 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IGSF23?
The strongest Open Targets associations for IGSF23 are neurodegenerative disease, mean platelet volume, leukocyte count, lymphocyte count and platelet count.
How long is the IGSF23 protein?
The Homo sapiens IGSF23 protein (UniProt A1L1A6) is 192 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A1L1A6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A1L1A6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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