Fibronectin type III and SPRY domain-containing protein 2 (FSD2)
Homo sapiens — UniProt A1L4K1
Data last refreshed: (UniProt release unknown)
Key facts
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) is a protein from Homo sapiens identified by UniProt accession A1L4K1, 749 residues long. MolForge cross-references it against 0 known binders and 96 disease associations.
- UniProt accession: A1L4K1; gene symbol FSD2.
- Organism: Homo sapiens.
- Length: 749 amino acids.
- Top disease associations (Open Targets): creatinine measurement, high density lipoprotein cholesterol measurement and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Fibronectin type III and SPRY domain-containing protein 2 |
|---|---|
| UniProt accession | A1L4K1 |
| Gene | FSD2 |
| Organism | Homo sapiens |
| Length | 749 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (96)
Diseases linked to this target (Open Targets).
- creatinine measurement · score 0.30
- high density lipoprotein cholesterol measurement · score 0.23
- platelet count · score 0.17
- type 2 diabetes mellitus · score 0.12
- forced expiratory volume · score 0.11
- breast ductal adenocarcinoma · score 0.11
- vital capacity · score 0.10
- age at first sexual intercourse measurement · score 0.08
- Brugada syndrome · score 0.07
- Arrhythmogenic right ventricular dysplasia · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A1L4K1-F1 | alphafold | PREDICTED | 73.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A1L4K1.
Amino-acid sequence (749 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FSD2?
The strongest Open Targets associations for FSD2 are creatinine measurement, high density lipoprotein cholesterol measurement, platelet count, type 2 diabetes mellitus and forced expiratory volume.
How long is the FSD2 protein?
The Homo sapiens FSD2 protein (UniProt A1L4K1) is 749 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A1L4K1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A1L4K1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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