CBY1-interacting BAR domain-containing protein 1…

About CBY1-interacting BAR domain-containing protein 1

CBY1-interacting BAR domain-containing protein 1 (CIBAR1) is a protein from Homo sapiens identified by UniProt accession A1XBS5, 289 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.

Target properties

Protein name	CBY1-interacting BAR domain-containing protein 1
UniProt accession	A1XBS5
Gene	CIBAR1
Organism	Homo sapiens
Length	289 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (49)

Diseases linked to this target (Open Targets).

polydactyly, postaxial, A9 · score 0.55
postaxial polydactyly type A · score 0.43
unipolar depression · score 0.26
age at menarche · score 0.20
hip circumference · score 0.05
hemoglobin D disease · score 0.05
MODY · score 0.05
diabetes mellitus, permanent neonatal 4 · score 0.04
Syndactyly type 2 · score 0.04
permanent neonatal diabetes mellitus 1 · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-A1XBS5-F1	alphafold	PREDICTED	85.10	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for A1XBS5.

Amino-acid sequence (289 residues)

MMRRTLENRN AQTKQLQTAV SNVEKHFGEL CQIFAAYVRK TARLRDKADL LVNEINAYAA TETPHLKLGL MNFADEFAKL QDYRQAEVER LEAKVVEPLK TYGTIVKMKR DDLKATLTAR NREAKQLTQL ERTRQRNPSD RHVISQAETE LQRAAMDASR TSRHLEETIN NFERQKMKDI KTIFSEFITI EMLFHGKALE VYTAAYQNIQ NIDEDEDLEV FRNSLYAPDY SSRLDIVRAN SKSPLQRSLS AKCVSGTGQV STCRLRKDQQ AEDDEDDELD VTEEENFLK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

CBY1-interacting BAR domain-containing protein 1 (CIBAR1)