ADP-ribose glycohydrolase MACROD2 (MACROD2)
Homo sapiens — UniProt A1Z1Q3
Data last refreshed: (UniProt release unknown)
Key facts
ADP-ribose glycohydrolase MACROD2 (MACROD2) is a protein from Homo sapiens identified by UniProt accession A1Z1Q3, 425 residues long. MolForge cross-references it against 0 known binders and 143 disease associations.
- UniProt accession: A1Z1Q3; gene symbol MACROD2.
- Organism: Homo sapiens.
- Length: 425 amino acids.
- Top disease associations (Open Targets): Kallmann syndrome, gut microbiome measurement and body mass index.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ADP-ribose glycohydrolase MACROD2 |
|---|---|
| UniProt accession | A1Z1Q3 |
| Gene | MACROD2 |
| Organism | Homo sapiens |
| Length | 425 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (143)
Diseases linked to this target (Open Targets).
- Kallmann syndrome · score 0.38
- gut microbiome measurement · score 0.33
- body mass index · score 0.30
- fat body mass · score 0.30
- body weight · score 0.29
- Uterine leiomyoma · score 0.28
- hypertension · score 0.28
- Epstein-Barr virus infection · score 0.28
- self reported educational attainment · score 0.27
- lean body mass · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A1Z1Q3-F1 | alphafold | PREDICTED | 71.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A1Z1Q3.
Amino-acid sequence (425 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MACROD2?
The strongest Open Targets associations for MACROD2 are Kallmann syndrome, gut microbiome measurement, body mass index, fat body mass and body weight.
How long is the MACROD2 protein?
The Homo sapiens MACROD2 protein (UniProt A1Z1Q3) is 425 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A1Z1Q3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A1Z1Q3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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