Ankyrin repeat domain-containing protein 18B (ANKRD18B)
Homo sapiens — UniProt A2A2Z9
Data last refreshed: (UniProt release unknown)
Key facts
Ankyrin repeat domain-containing protein 18B (ANKRD18B) is a protein from Homo sapiens identified by UniProt accession A2A2Z9, 1011 residues long. MolForge cross-references it against 0 known binders and 16 disease associations.
- UniProt accession: A2A2Z9; gene symbol ANKRD18B.
- Organism: Homo sapiens.
- Length: 1011 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, non-small cell lung carcinoma and electrocardiography.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ankyrin repeat domain-containing protein 18B |
|---|---|
| UniProt accession | A2A2Z9 |
| Gene | ANKRD18B |
| Organism | Homo sapiens |
| Length | 1011 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (16)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.21
- non-small cell lung carcinoma · score 0.04
- electrocardiography · score 0.04
- emotional symptom measurement · score 0.03
- Immature Reticulocyte Fraction Measurement · score 0.02
- type 2 diabetes mellitus · score 0.02
- mean corpuscular volume · score 0.02
- lymphocyte count · score 0.02
- heel bone mineral density · score 0.02
- mean reticulocyte volume · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A2A2Z9-F1 | alphafold | PREDICTED | 72.03 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A2A2Z9.
Amino-acid sequence (1011 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ANKRD18B?
The strongest Open Targets associations for ANKRD18B are neurodegenerative disease, non-small cell lung carcinoma, electrocardiography, emotional symptom measurement and Immature Reticulocyte Fraction Measurement.
How long is the ANKRD18B protein?
The Homo sapiens ANKRD18B protein (UniProt A2A2Z9) is 1011 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A2A2Z9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A2A2Z9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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