Protein tyrosine phosphatase domain-containing protein 1 (PTPDC1)
Homo sapiens — UniProt A2A3K4
Data last refreshed: (UniProt release unknown)
Key facts
Protein tyrosine phosphatase domain-containing protein 1 (PTPDC1) is a protein from Homo sapiens identified by UniProt accession A2A3K4, 754 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.
- UniProt accession: A2A3K4; gene symbol PTPDC1.
- Organism: Homo sapiens.
- Length: 754 amino acids.
- Top disease associations (Open Targets): neurofibrillary tangles measurement, heel bone mineral density and BMI-adjusted hip circumference.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein tyrosine phosphatase domain-containing protein 1 |
|---|---|
| UniProt accession | A2A3K4 |
| Gene | PTPDC1 |
| Organism | Homo sapiens |
| Length | 754 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- neurofibrillary tangles measurement · score 0.24
- heel bone mineral density · score 0.24
- BMI-adjusted hip circumference · score 0.23
- body height · score 0.23
- birth weight · score 0.20
- waist-hip ratio · score 0.19
- diabetes mellitus · score 0.19
- calcium measurement · score 0.19
- peak expiratory flow · score 0.18
- urate measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A2A3K4-F1 | alphafold | PREDICTED | 69.98 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A2A3K4.
Amino-acid sequence (754 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PTPDC1?
The strongest Open Targets associations for PTPDC1 are neurofibrillary tangles measurement, heel bone mineral density, BMI-adjusted hip circumference, body height and birth weight.
How long is the PTPDC1 protein?
The Homo sapiens PTPDC1 protein (UniProt A2A3K4) is 754 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A2A3K4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A2A3K4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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