Transmembrane protein 218 (TMEM218)
Homo sapiens — UniProt A2RU14
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 218 (TMEM218) is a protein from Homo sapiens identified by UniProt accession A2RU14, 115 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.
- UniProt accession: A2RU14; gene symbol TMEM218.
- Organism: Homo sapiens.
- Length: 115 amino acids.
- Top disease associations (Open Targets): Joubert syndrome 39, Joubert syndrome and Meckel syndrome, type 4.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 218 |
|---|---|
| UniProt accession | A2RU14 |
| Gene | TMEM218 |
| Organism | Homo sapiens |
| Length | 115 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (53)
Diseases linked to this target (Open Targets).
- Joubert syndrome 39 · score 0.68
- Joubert syndrome · score 0.55
- Meckel syndrome, type 4 · score 0.42
- ciliopathy · score 0.38
- brain volume measurement · score 0.12
- functional brain measurement · score 0.12
- heel bone mineral density · score 0.06
- renal coloboma syndrome · score 0.04
- tubulointerstitial kidney disease, autosomal dominant, 2 · score 0.04
- primary membranoproliferative glomerulonephritis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A2RU14-F1 | alphafold | PREDICTED | 87.65 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A2RU14.
Amino-acid sequence (115 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM218?
The strongest Open Targets associations for TMEM218 are Joubert syndrome 39, Joubert syndrome, Meckel syndrome, type 4, ciliopathy and brain volume measurement.
How long is the TMEM218 protein?
The Homo sapiens TMEM218 protein (UniProt A2RU14) is 115 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A2RU14 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A2RU14 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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