Single-pass membrane and coiled-coil domain-containing protein 3 (SMCO3)
Homo sapiens — UniProt A2RU48
Data last refreshed: (UniProt release unknown)
Key facts
Single-pass membrane and coiled-coil domain-containing protein 3 (SMCO3) is a protein from Homo sapiens identified by UniProt accession A2RU48, 225 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.
- UniProt accession: A2RU48; gene symbol SMCO3.
- Organism: Homo sapiens.
- Length: 225 amino acids.
- Top disease associations (Open Targets): fat body mass, base metabolic rate measurement and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Single-pass membrane and coiled-coil domain-containing protein 3 |
|---|---|
| UniProt accession | A2RU48 |
| Gene | SMCO3 |
| Organism | Homo sapiens |
| Length | 225 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (11)
Diseases linked to this target (Open Targets).
- fat body mass · score 0.10
- base metabolic rate measurement · score 0.09
- lean body mass · score 0.08
- BMI-adjusted hip circumference · score 0.07
- prostate carcinoma · score 0.05
- appendicular lean mass · score 0.05
- body height · score 0.04
- sitting height measurement · score 0.04
- whole body water mass · score 0.03
- clear cell renal carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-A2RU48-F1 | alphafold | PREDICTED | 80.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for A2RU48.
Amino-acid sequence (225 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SMCO3?
The strongest Open Targets associations for SMCO3 are fat body mass, base metabolic rate measurement, lean body mass, BMI-adjusted hip circumference and prostate carcinoma.
How long is the SMCO3 protein?
The Homo sapiens SMCO3 protein (UniProt A2RU48) is 225 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB A2RU48 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB A2RU48 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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